What Systems Biology Can Tell Us about Disease
A recent debate has touched upon the question of whether diseases can be understood as dysfunctional mechanisms or whether there are "pathological" mechanisms that deserve to be investigated and explained independently (Nervi 2010; Moghaddam-Taaheri 2011). Here I suggest that both views te...
Gespeichert in:
| Veröffentlicht in: | History and philosophy of the life sciences 2011-01, Vol.33 (4), p.477-496 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 496 |
|---|---|
| container_issue | 4 |
| container_start_page | 477 |
| container_title | History and philosophy of the life sciences |
| container_volume | 33 |
| creator | Gross, Fridolin |
| description | A recent debate has touched upon the question of whether diseases can be understood as dysfunctional mechanisms or whether there are "pathological" mechanisms that deserve to be investigated and explained independently (Nervi 2010; Moghaddam-Taaheri 2011). Here I suggest that both views tell us something important about disease but that in many instances only a systemic view can shed light on the relationship between physiology and pathology. I provide examples from the literature in systems biology in support of my position. As a result of my analysis, I conclude that a perspective narrowly focusing on mechanisms is insufficient if the goal is to get a comprehensive picture of disease. |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1018861038</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>23335179</jstor_id><sourcerecordid>23335179</sourcerecordid><originalsourceid>FETCH-LOGICAL-j233t-1eb02eb9287fadb42278005c600ff9f45e1f881901f4e4e95e7786f56aa774ab3</originalsourceid><addsrcrecordid>eNpFzztPwzAUBWALgWgp_ASQR5ag67c9QnhKlRhoxRg57TUkSpoSO0P-PZFaxHSH8-no3BMyZ0byTAumT8kchGOZM0zOyEWMNQBoBeaczDjXmivQc3L3-e0T_RhjwjbSh6pruq-R5n5HV9g0dB2pL7sh0ccqoo94Sc6CbyJeHe-CrJ-fVvlrtnx_ecvvl1nNhUgZwxI4lo5bE_y2lJwbC6A2GiAEF6RCFqxlDliQKNEpNMbqoLT3xkhfigW5PfTu--5nwJiKtoqbaZHfYTfEggGzVjMQdqI3RzqULW6LfV-1vh-Lvx8ncH0AdUxd_58LIRQzTvwCy-lVgA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1018861038</pqid></control><display><type>article</type><title>What Systems Biology Can Tell Us about Disease</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><creator>Gross, Fridolin</creator><creatorcontrib>Gross, Fridolin</creatorcontrib><description>A recent debate has touched upon the question of whether diseases can be understood as dysfunctional mechanisms or whether there are "pathological" mechanisms that deserve to be investigated and explained independently (Nervi 2010; Moghaddam-Taaheri 2011). Here I suggest that both views tell us something important about disease but that in many instances only a systemic view can shed light on the relationship between physiology and pathology. I provide examples from the literature in systems biology in support of my position. As a result of my analysis, I conclude that a perspective narrowly focusing on mechanisms is insufficient if the goal is to get a comprehensive picture of disease.</description><identifier>ISSN: 0391-9714</identifier><identifier>EISSN: 1742-6316</identifier><identifier>PMID: 22662506</identifier><language>eng</language><publisher>Switzerland: Giannini Editore</publisher><subject>Alzheimers disease ; Cancer ; Diseases ; Genetic mutation ; History of medicine and histology ; Humans ; Mathematical robustness ; Metabolic diseases ; Metabolic Syndrome - pathology ; Metabolic Syndrome - physiopathology ; Neoplasms - pathology ; Neoplasms - physiopathology ; Pathology ; Philosophy, Medical ; Somatic cells ; Stem cells ; Systems Biology</subject><ispartof>History and philosophy of the life sciences, 2011-01, Vol.33 (4), p.477-496</ispartof><rights>Copyright © 2011 Stazione Zoologica Anton Dohrn</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23335179$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23335179$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4009,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22662506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gross, Fridolin</creatorcontrib><title>What Systems Biology Can Tell Us about Disease</title><title>History and philosophy of the life sciences</title><addtitle>Hist Philos Life Sci</addtitle><description>A recent debate has touched upon the question of whether diseases can be understood as dysfunctional mechanisms or whether there are "pathological" mechanisms that deserve to be investigated and explained independently (Nervi 2010; Moghaddam-Taaheri 2011). Here I suggest that both views tell us something important about disease but that in many instances only a systemic view can shed light on the relationship between physiology and pathology. I provide examples from the literature in systems biology in support of my position. As a result of my analysis, I conclude that a perspective narrowly focusing on mechanisms is insufficient if the goal is to get a comprehensive picture of disease.</description><subject>Alzheimers disease</subject><subject>Cancer</subject><subject>Diseases</subject><subject>Genetic mutation</subject><subject>History of medicine and histology</subject><subject>Humans</subject><subject>Mathematical robustness</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - pathology</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - physiopathology</subject><subject>Pathology</subject><subject>Philosophy, Medical</subject><subject>Somatic cells</subject><subject>Stem cells</subject><subject>Systems Biology</subject><issn>0391-9714</issn><issn>1742-6316</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFzztPwzAUBWALgWgp_ASQR5ag67c9QnhKlRhoxRg57TUkSpoSO0P-PZFaxHSH8-no3BMyZ0byTAumT8kchGOZM0zOyEWMNQBoBeaczDjXmivQc3L3-e0T_RhjwjbSh6pruq-R5n5HV9g0dB2pL7sh0ccqoo94Sc6CbyJeHe-CrJ-fVvlrtnx_ecvvl1nNhUgZwxI4lo5bE_y2lJwbC6A2GiAEF6RCFqxlDliQKNEpNMbqoLT3xkhfigW5PfTu--5nwJiKtoqbaZHfYTfEggGzVjMQdqI3RzqULW6LfV-1vh-Lvx8ncH0AdUxd_58LIRQzTvwCy-lVgA</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Gross, Fridolin</creator><general>Giannini Editore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>What Systems Biology Can Tell Us about Disease</title><author>Gross, Fridolin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j233t-1eb02eb9287fadb42278005c600ff9f45e1f881901f4e4e95e7786f56aa774ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alzheimers disease</topic><topic>Cancer</topic><topic>Diseases</topic><topic>Genetic mutation</topic><topic>History of medicine and histology</topic><topic>Humans</topic><topic>Mathematical robustness</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - pathology</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - physiopathology</topic><topic>Pathology</topic><topic>Philosophy, Medical</topic><topic>Somatic cells</topic><topic>Stem cells</topic><topic>Systems Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gross, Fridolin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>History and philosophy of the life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gross, Fridolin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What Systems Biology Can Tell Us about Disease</atitle><jtitle>History and philosophy of the life sciences</jtitle><addtitle>Hist Philos Life Sci</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>33</volume><issue>4</issue><spage>477</spage><epage>496</epage><pages>477-496</pages><issn>0391-9714</issn><eissn>1742-6316</eissn><abstract>A recent debate has touched upon the question of whether diseases can be understood as dysfunctional mechanisms or whether there are "pathological" mechanisms that deserve to be investigated and explained independently (Nervi 2010; Moghaddam-Taaheri 2011). Here I suggest that both views tell us something important about disease but that in many instances only a systemic view can shed light on the relationship between physiology and pathology. I provide examples from the literature in systems biology in support of my position. As a result of my analysis, I conclude that a perspective narrowly focusing on mechanisms is insufficient if the goal is to get a comprehensive picture of disease.</abstract><cop>Switzerland</cop><pub>Giannini Editore</pub><pmid>22662506</pmid><tpages>20</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-9714 |
| ispartof | History and philosophy of the life sciences, 2011-01, Vol.33 (4), p.477-496 |
| issn | 0391-9714 1742-6316 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1018861038 |
| source | MEDLINE; Jstor Complete Legacy |
| subjects | Alzheimers disease Cancer Diseases Genetic mutation History of medicine and histology Humans Mathematical robustness Metabolic diseases Metabolic Syndrome - pathology Metabolic Syndrome - physiopathology Neoplasms - pathology Neoplasms - physiopathology Pathology Philosophy, Medical Somatic cells Stem cells Systems Biology |
| title | What Systems Biology Can Tell Us about Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T18%3A55%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=What%20Systems%20Biology%20Can%20Tell%20Us%20about%20Disease&rft.jtitle=History%20and%20philosophy%20of%20the%20life%20sciences&rft.au=Gross,%20Fridolin&rft.date=2011-01-01&rft.volume=33&rft.issue=4&rft.spage=477&rft.epage=496&rft.pages=477-496&rft.issn=0391-9714&rft.eissn=1742-6316&rft_id=info:doi/&rft_dat=%3Cjstor_proqu%3E23335179%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1018861038&rft_id=info:pmid/22662506&rft_jstor_id=23335179&rfr_iscdi=true |