KLEIP deficiency in mice causes progressive corneal neovascular dystrophy

The BTB-kelch protein KLEIP/KLHL20 is an actin binding protein that regulates cell-cell contact formation and cell migration. The aim of our study was to characterize KLEIP's function in ocular health and disease in mice. KLEIP(-/-) mice were generated, and corneas were examined histologically...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2012-05, Vol.53 (6), p.3260-3268
Hauptverfasser:	Hahn, Nicole, Dietz, Christian T, Kühl, Sandra, Vossmerbaeumer, Urs, Kroll, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - biosynthesis Carrier Proteins - genetics Cornea - metabolism Cornea - pathology Corneal Neovascularization - complications Corneal Neovascularization - metabolism Corneal Neovascularization - pathology Corneal Opacity - etiology Corneal Opacity - genetics Corneal Opacity - pathology Disease Models, Animal Disease Progression Gene Expression Regulation Genotype Mice Mice, Inbred C57BL Mice, Transgenic Real-Time Polymerase Chain Reaction RNA, Messenger - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!