Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite
We have developed a technology for the electrical polarization and electrical characterization of hydroxyapatite (HA) microgranules. In order to improve handling of ceramic powders to fulfill complex geometrical demands, platelet-rich plasma (PRP) containing many growth factors was chosen as a carri...
Gespeichert in:
| Veröffentlicht in: | Acta biomaterialia 2012-07, Vol.8 (7), p.2778-2787 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2787 |
|---|---|
| container_issue | 7 |
| container_start_page | 2778 |
| container_title | Acta biomaterialia |
| container_volume | 8 |
| creator | Ohba, Seiko Wang, Wei Itoh, Soichiro Takagi, Yuzo Nagai, Akiko Yamashita, Kimihiro |
| description | We have developed a technology for the electrical polarization and electrical characterization of hydroxyapatite (HA) microgranules. In order to improve handling of ceramic powders to fulfill complex geometrical demands, platelet-rich plasma (PRP) containing many growth factors was chosen as a carrier of HA microgranules. In this study, the effects of this electrically polarized HA microgranule/PRP composite on new bone formation were examined. To compare osteoconductivity, HA microgranules with or without electrical polarization/PRP composite gel, HA microgranules alone with or without electrical polarization, or PRP gel were implanted into holes in the medial femoral condyles of rabbits. As a control, some of the bone holes were left empty (n=6 in each group). Histological examination was performed 3 and 6weeks after the surgical operation. It was suggested that PRP alone could not induce new bone formation until 6weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation, and that this effect is enhanced by forming a complex within the PRP. |
| doi_str_mv | 10.1016/j.actbio.2012.04.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1018633977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1742706112001626</els_id><sourcerecordid>1018633977</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-bc0532dcc4d55c31144c96d500e531a0c031f5d9f930e356033fa30ff5b7f2ea3</originalsourceid><addsrcrecordid>eNp9kEtv1TAQRi0EoqXlHyDwkk3ScWwnuRukqioPqRIL2rXlOOPWV0kc7Fxo-uuZqxSWrPzQ-eZxGHsnoBQg6ot9ad3ShVhWIKoSVAlCv2Cnom3aotF1-5LujaqKBmpxwt7kvAeQraja1-ykqrQABfKUPV06hwMmu4Q48ej5hL95FyfkPqZx--1WbidOlFtScHYYVj7HwabwhD1_WPsUH1c7E7sgH4NL8T7Z6TDgxTzYhWJLQbEHTq88Wu7iOMdM7Dl75e2Q8e3zecbuPl_fXn0tbr5_-XZ1eVM4paul6BxoWfXOqV5rJ4VQyu3qXgOglsKCAym87nd-JwGlrkFKbyV4r7vGV2jlGfu41Z1T_HnAvJgxZFp6sBPGQzZks62l3DUNoWpDaYmcE3ozpzDatBJ05GqzN5t1c7RuQBmyTrH3zx0O3Yj9v9BfzQR82ABvo7H3KWRz94Mq0BICWtUeO3_aCCQTvwImk13AyWEfEnk3fQz_n-EPZvOhCA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1018633977</pqid></control><display><type>article</type><title>Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ohba, Seiko ; Wang, Wei ; Itoh, Soichiro ; Takagi, Yuzo ; Nagai, Akiko ; Yamashita, Kimihiro</creator><creatorcontrib>Ohba, Seiko ; Wang, Wei ; Itoh, Soichiro ; Takagi, Yuzo ; Nagai, Akiko ; Yamashita, Kimihiro</creatorcontrib><description>We have developed a technology for the electrical polarization and electrical characterization of hydroxyapatite (HA) microgranules. In order to improve handling of ceramic powders to fulfill complex geometrical demands, platelet-rich plasma (PRP) containing many growth factors was chosen as a carrier of HA microgranules. In this study, the effects of this electrically polarized HA microgranule/PRP composite on new bone formation were examined. To compare osteoconductivity, HA microgranules with or without electrical polarization/PRP composite gel, HA microgranules alone with or without electrical polarization, or PRP gel were implanted into holes in the medial femoral condyles of rabbits. As a control, some of the bone holes were left empty (n=6 in each group). Histological examination was performed 3 and 6weeks after the surgical operation. It was suggested that PRP alone could not induce new bone formation until 6weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation, and that this effect is enhanced by forming a complex within the PRP.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2012.04.015</identifier><identifier>PMID: 22510403</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; bone formation ; ceramics ; Durapatite - pharmacology ; Electrical polarization ; Electricity ; Femur - diagnostic imaging ; Femur - drug effects ; Femur - pathology ; Femur - surgery ; gels ; growth factors ; Hydroxyapatite ; Implants, Experimental ; Microscopy, Electron, Scanning ; Microspheres ; Osteoconductivity ; Osteogenesis - drug effects ; Osteogenic cell ; Platelet-rich plasma ; Platelet-Rich Plasma - metabolism ; powders ; Rabbits ; X-Ray Diffraction ; X-Ray Microtomography</subject><ispartof>Acta biomaterialia, 2012-07, Vol.8 (7), p.2778-2787</ispartof><rights>2012 Acta Materialia Inc.</rights><rights>Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-bc0532dcc4d55c31144c96d500e531a0c031f5d9f930e356033fa30ff5b7f2ea3</citedby><cites>FETCH-LOGICAL-c452t-bc0532dcc4d55c31144c96d500e531a0c031f5d9f930e356033fa30ff5b7f2ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706112001626$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22510403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohba, Seiko</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Itoh, Soichiro</creatorcontrib><creatorcontrib>Takagi, Yuzo</creatorcontrib><creatorcontrib>Nagai, Akiko</creatorcontrib><creatorcontrib>Yamashita, Kimihiro</creatorcontrib><title>Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>We have developed a technology for the electrical polarization and electrical characterization of hydroxyapatite (HA) microgranules. In order to improve handling of ceramic powders to fulfill complex geometrical demands, platelet-rich plasma (PRP) containing many growth factors was chosen as a carrier of HA microgranules. In this study, the effects of this electrically polarized HA microgranule/PRP composite on new bone formation were examined. To compare osteoconductivity, HA microgranules with or without electrical polarization/PRP composite gel, HA microgranules alone with or without electrical polarization, or PRP gel were implanted into holes in the medial femoral condyles of rabbits. As a control, some of the bone holes were left empty (n=6 in each group). Histological examination was performed 3 and 6weeks after the surgical operation. It was suggested that PRP alone could not induce new bone formation until 6weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation, and that this effect is enhanced by forming a complex within the PRP.</description><subject>Animals</subject><subject>bone formation</subject><subject>ceramics</subject><subject>Durapatite - pharmacology</subject><subject>Electrical polarization</subject><subject>Electricity</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - drug effects</subject><subject>Femur - pathology</subject><subject>Femur - surgery</subject><subject>gels</subject><subject>growth factors</subject><subject>Hydroxyapatite</subject><subject>Implants, Experimental</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microspheres</subject><subject>Osteoconductivity</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenic cell</subject><subject>Platelet-rich plasma</subject><subject>Platelet-Rich Plasma - metabolism</subject><subject>powders</subject><subject>Rabbits</subject><subject>X-Ray Diffraction</subject><subject>X-Ray Microtomography</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1TAQRi0EoqXlHyDwkk3ScWwnuRukqioPqRIL2rXlOOPWV0kc7Fxo-uuZqxSWrPzQ-eZxGHsnoBQg6ot9ad3ShVhWIKoSVAlCv2Cnom3aotF1-5LujaqKBmpxwt7kvAeQraja1-ykqrQABfKUPV06hwMmu4Q48ej5hL95FyfkPqZx--1WbidOlFtScHYYVj7HwabwhD1_WPsUH1c7E7sgH4NL8T7Z6TDgxTzYhWJLQbEHTq88Wu7iOMdM7Dl75e2Q8e3zecbuPl_fXn0tbr5_-XZ1eVM4paul6BxoWfXOqV5rJ4VQyu3qXgOglsKCAym87nd-JwGlrkFKbyV4r7vGV2jlGfu41Z1T_HnAvJgxZFp6sBPGQzZks62l3DUNoWpDaYmcE3ozpzDatBJ05GqzN5t1c7RuQBmyTrH3zx0O3Yj9v9BfzQR82ABvo7H3KWRz94Mq0BICWtUeO3_aCCQTvwImk13AyWEfEnk3fQz_n-EPZvOhCA</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Ohba, Seiko</creator><creator>Wang, Wei</creator><creator>Itoh, Soichiro</creator><creator>Takagi, Yuzo</creator><creator>Nagai, Akiko</creator><creator>Yamashita, Kimihiro</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite</title><author>Ohba, Seiko ; Wang, Wei ; Itoh, Soichiro ; Takagi, Yuzo ; Nagai, Akiko ; Yamashita, Kimihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-bc0532dcc4d55c31144c96d500e531a0c031f5d9f930e356033fa30ff5b7f2ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>bone formation</topic><topic>ceramics</topic><topic>Durapatite - pharmacology</topic><topic>Electrical polarization</topic><topic>Electricity</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - drug effects</topic><topic>Femur - pathology</topic><topic>Femur - surgery</topic><topic>gels</topic><topic>growth factors</topic><topic>Hydroxyapatite</topic><topic>Implants, Experimental</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microspheres</topic><topic>Osteoconductivity</topic><topic>Osteogenesis - drug effects</topic><topic>Osteogenic cell</topic><topic>Platelet-rich plasma</topic><topic>Platelet-Rich Plasma - metabolism</topic><topic>powders</topic><topic>Rabbits</topic><topic>X-Ray Diffraction</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohba, Seiko</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Itoh, Soichiro</creatorcontrib><creatorcontrib>Takagi, Yuzo</creatorcontrib><creatorcontrib>Nagai, Akiko</creatorcontrib><creatorcontrib>Yamashita, Kimihiro</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohba, Seiko</au><au>Wang, Wei</au><au>Itoh, Soichiro</au><au>Takagi, Yuzo</au><au>Nagai, Akiko</au><au>Yamashita, Kimihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>8</volume><issue>7</issue><spage>2778</spage><epage>2787</epage><pages>2778-2787</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>We have developed a technology for the electrical polarization and electrical characterization of hydroxyapatite (HA) microgranules. In order to improve handling of ceramic powders to fulfill complex geometrical demands, platelet-rich plasma (PRP) containing many growth factors was chosen as a carrier of HA microgranules. In this study, the effects of this electrically polarized HA microgranule/PRP composite on new bone formation were examined. To compare osteoconductivity, HA microgranules with or without electrical polarization/PRP composite gel, HA microgranules alone with or without electrical polarization, or PRP gel were implanted into holes in the medial femoral condyles of rabbits. As a control, some of the bone holes were left empty (n=6 in each group). Histological examination was performed 3 and 6weeks after the surgical operation. It was suggested that PRP alone could not induce new bone formation until 6weeks after implantation. HA microgranules with or without electrical polarization/PRP composite, especially the former, activated osteogenic cells, resulting in enhanced bone formation. It was confirmed that electrical polarization treatment of HA microgranules can accelerate new bone formation, and that this effect is enhanced by forming a complex within the PRP.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22510403</pmid><doi>10.1016/j.actbio.2012.04.015</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2012-07, Vol.8 (7), p.2778-2787 |
| issn | 1742-7061 1878-7568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1018633977 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals bone formation ceramics Durapatite - pharmacology Electrical polarization Electricity Femur - diagnostic imaging Femur - drug effects Femur - pathology Femur - surgery gels growth factors Hydroxyapatite Implants, Experimental Microscopy, Electron, Scanning Microspheres Osteoconductivity Osteogenesis - drug effects Osteogenic cell Platelet-rich plasma Platelet-Rich Plasma - metabolism powders Rabbits X-Ray Diffraction X-Ray Microtomography |
| title | Acceleration of new bone formation by an electrically polarized hydroxyapatite microgranule/platelet-rich plasma composite |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T09%3A33%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acceleration%20of%20new%20bone%20formation%20by%20an%20electrically%20polarized%20hydroxyapatite%20microgranule/platelet-rich%20plasma%20composite&rft.jtitle=Acta%20biomaterialia&rft.au=Ohba,%20Seiko&rft.date=2012-07-01&rft.volume=8&rft.issue=7&rft.spage=2778&rft.epage=2787&rft.pages=2778-2787&rft.issn=1742-7061&rft.eissn=1878-7568&rft_id=info:doi/10.1016/j.actbio.2012.04.015&rft_dat=%3Cproquest_cross%3E1018633977%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1018633977&rft_id=info:pmid/22510403&rft_els_id=S1742706112001626&rfr_iscdi=true |