A Peptidomimetic Tight Junction Modulator To Improve Regional Analgesia

The paracellular flux of solutes through tissue barriers is limited by transmembrane tight junction proteins. Within the family of tight junction proteins, claudin-1 seems to be a key protein for tightness formation and integrity. In the peripheral nervous system, the nerve fibers are surrounded wit...

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Veröffentlicht in:	Molecular pharmaceutics 2012-06, Vol.9 (6), p.1785-1794
Hauptverfasser:	Zwanziger, Denise, Hackel, Dagmar, Staat, Christian, Böcker, Alexander, Brack, Alexander, Beyermann, Michael, Rittner, Heike, Blasig, Ingolf E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Animals Blotting, Western Caco-2 Cells Cell Line Circular Dichroism Claudin-1 - chemistry Humans Immunohistochemistry Male Microscopy, Confocal Peptides - chemistry Peptides - pharmacology Peptidomimetics - chemistry Peptidomimetics - metabolism Peripheral Nerves - drug effects Peripheral Nerves - metabolism Rats Rats, Wistar Sciatic Nerve - drug effects Sciatic Nerve - metabolism Tight Junctions - metabolism
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