Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells

► Ultrasound induces phosphorylation of Checkpoint kinase 1 (Chk1). ► The phosphorylation of Chk1 is dependent on ataxia telangiectasia mutated- and Rad3-related (ATR). ► The activated Chk1 is involved in ultrasound-induced apoptosis. Low-intensity ultrasound (US) has been shown to induce death of c...

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Veröffentlicht in:	Ultrasonics sonochemistry 2012-11, Vol.19 (6), p.1246-1251
Hauptverfasser:	Furusawa, Yukihiro, Iizumi, Takashi, Fujiwara, Yoshisada, Hassan, Mariame Ali, Tabuchi, Yoshiaki, Nomura, Takaharu, Kondo, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Ataxia Telangiectasia Mutated Proteins ATR Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Checkpoint Kinase 1 Chemistry Chk1 DNA Damage DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Exact sciences and technology General and physical chemistry HL-60 Cells Humans Jurkat Cells Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Phosphorylation - drug effects Physical chemistry of induced reactions (with radiations, particles and ultrasonics) Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering Sonication Structure-Activity Relationship Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism U937 Cells Ultrasonic chemistry Ultrasound
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