Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury

Mer as an intrinsic feedback inhibitor of the TLR4‐driven immune responses during acute lung injury. Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down‐regulation of TLR4 activation‐driven...

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Veröffentlicht in:	Journal of leukocyte biology 2012-06, Vol.91 (6), p.921-932
Hauptverfasser:	Lee, Ye‐Ji, Han, Ji‐Young, Byun, Jiyeon, Park, Hyun‐Jeong, Park, Eun‐Mi, Chong, Young Hae, Cho, Min‐Sun, Kang, Jihee Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - genetics Acute Lung Injury - immunology alveolar macrophages Animals c-Mer Tyrosine Kinase Cytokines - genetics Cytokines - immunology Enzyme Activation - drug effects Enzyme Activation - genetics Enzyme Activation - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - immunology Inflammation Mediators - immunology inflammatory mediators Lipopolysaccharides - toxicity Macrophages, Alveolar - immunology Macrophages, Alveolar - pathology Male Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - immunology Mer signaling Mice Mice, Inbred BALB C NF-kappa B - genetics NF-kappa B - immunology Phosphorylation - drug effects Phosphorylation - genetics Phosphorylation - immunology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology pulmonary inflammation Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - immunology soluble Mer STAT1 Transcription Factor - genetics STAT1 Transcription Factor - immunology Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - immunology Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology
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