Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study
Summary The biodiversity in South Africa provides more than 30 000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African t...
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| Veröffentlicht in: | Andrologia 2012-05, Vol.44 (s1), p.287-294 |
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| creator | Henkel, R. Fransman, W. Hipler, U.-C. Wiegand, C. Schreiber, G. Menkveld, R. Weitz, F. Fisher, D. |
| description | Summary
The biodiversity in South Africa provides more than 30 000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African traditional healers have been recognised by Law and the health benefits of T. capensis have not been scientifically investigated yet, this study aimed at investigating the in vitro effects of aqueous extracts from this plant on male reproductive functions. Both leaves and rhizomes of T. capensis were dried, infused with distilled water and freeze–dried. Motile sperm from 50 men were isolated by swim‐up and incubated with 1 μg ml−1 aqueous extract of Typha rhizome for 1 h at 37 °C. Vitality, motility, sperm production of reactive oxygen species and mitochondrial membrane potential were analysed in the test sample, a control and in the pellet from the swim‐up. Results showed that the rhizome extract had significant (P |
| doi_str_mv | 10.1111/j.1439-0272.2011.01179.x |
| format | Article |
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The biodiversity in South Africa provides more than 30 000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African traditional healers have been recognised by Law and the health benefits of T. capensis have not been scientifically investigated yet, this study aimed at investigating the in vitro effects of aqueous extracts from this plant on male reproductive functions. Both leaves and rhizomes of T. capensis were dried, infused with distilled water and freeze–dried. Motile sperm from 50 men were isolated by swim‐up and incubated with 1 μg ml−1 aqueous extract of Typha rhizome for 1 h at 37 °C. Vitality, motility, sperm production of reactive oxygen species and mitochondrial membrane potential were analysed in the test sample, a control and in the pellet from the swim‐up. Results showed that the rhizome extract had significant (P < 0.0001) negative effects on all parameters. The extracts from the leaves and rhizomes revealed dose‐dependent inhibitory activity for collagenase and free radical formation. No inhibitory activity for elastase was found. The inhibitory activity for collagenase might indicate possible anti‐cancer effects.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/j.1439-0272.2011.01179.x</identifier><identifier>PMID: 21729138</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>African traditional medicine ; Enzyme Inhibitors - pharmacology ; Free Radical Scavengers - pharmacology ; Humans ; Male ; Matrix Metalloproteinase Inhibitors ; Membrane Potentials - drug effects ; Mitochondria - drug effects ; mitochondrial membrane potential ; Pilot Projects ; Plant Extracts - pharmacology ; reactive oxygen species ; sperm motility ; Sperm Motility - drug effects ; Typha capensis ; Typhaceae - chemistry</subject><ispartof>Andrologia, 2012-05, Vol.44 (s1), p.287-294</ispartof><rights>2011 Blackwell Verlag GmbH</rights><rights>2011 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4089-4a42c694b74524d2a602b8aedc0551c248c6b33fb01e27d43e91abe8b7d1188e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0272.2011.01179.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0272.2011.01179.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21729138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henkel, R.</creatorcontrib><creatorcontrib>Fransman, W.</creatorcontrib><creatorcontrib>Hipler, U.-C.</creatorcontrib><creatorcontrib>Wiegand, C.</creatorcontrib><creatorcontrib>Schreiber, G.</creatorcontrib><creatorcontrib>Menkveld, R.</creatorcontrib><creatorcontrib>Weitz, F.</creatorcontrib><creatorcontrib>Fisher, D.</creatorcontrib><title>Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
The biodiversity in South Africa provides more than 30 000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African traditional healers have been recognised by Law and the health benefits of T. capensis have not been scientifically investigated yet, this study aimed at investigating the in vitro effects of aqueous extracts from this plant on male reproductive functions. Both leaves and rhizomes of T. capensis were dried, infused with distilled water and freeze–dried. Motile sperm from 50 men were isolated by swim‐up and incubated with 1 μg ml−1 aqueous extract of Typha rhizome for 1 h at 37 °C. Vitality, motility, sperm production of reactive oxygen species and mitochondrial membrane potential were analysed in the test sample, a control and in the pellet from the swim‐up. Results showed that the rhizome extract had significant (P < 0.0001) negative effects on all parameters. The extracts from the leaves and rhizomes revealed dose‐dependent inhibitory activity for collagenase and free radical formation. No inhibitory activity for elastase was found. The inhibitory activity for collagenase might indicate possible anti‐cancer effects.</description><subject>African traditional medicine</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Membrane Potentials - drug effects</subject><subject>Mitochondria - drug effects</subject><subject>mitochondrial membrane potential</subject><subject>Pilot Projects</subject><subject>Plant Extracts - pharmacology</subject><subject>reactive oxygen species</subject><subject>sperm motility</subject><subject>Sperm Motility - drug effects</subject><subject>Typha capensis</subject><subject>Typhaceae - chemistry</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kW9v0zAQxiMEYtXYV0B-2Ukk87_UCRIvxhgDUYqGBuOdZTvXxSVxgp1s7Qfke-HQrSedbN39ntPZT5IggjMS42yTEc7KFFNBM4oJyWKKMts-S2aHxvNkhhlmKc8X5VFyEsIGx-C5EJy_TI4oEbQkrJglf292fa2QUT24YAOaf-9qr7PTVXaZvfcZmuux8WOoTxFsB6_MgIJR9-DuIKC1B0BeVdaoJrxB1tVW2yEg0zWNugOnAqCosPd22CHlKqTWazARqMdWORR68C1qu8E2T0Brh87Unau8VQ1qodVeOUB9N4AbppJ1KE7z3VukUG-bLq4zjNXuVfJiHXeAk8fzOPnx8fLm4lO6_Hb1-eJ8mRqOizLlilOzKLkWPKe8omqBqS4UVAbnOTGUF2ahGVtrTICKijMoidJQaFERUhTAjpP5fm7vuz8jhEG2NhiIz3XQjUESTAqWY8xERF8_oqNuoZK9t63yO_n09RF4twcebAO7Q59gObksN3IyU05mysll-d9luZXnqw_TLerTvd6GAbYHvfK_5UIwkcvb1ZUU18sv17--3sqf7B8Xeq08</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Henkel, R.</creator><creator>Fransman, W.</creator><creator>Hipler, U.-C.</creator><creator>Wiegand, C.</creator><creator>Schreiber, G.</creator><creator>Menkveld, R.</creator><creator>Weitz, F.</creator><creator>Fisher, D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201205</creationdate><title>Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study</title><author>Henkel, R. ; Fransman, W. ; Hipler, U.-C. ; Wiegand, C. ; Schreiber, G. ; Menkveld, R. ; Weitz, F. ; Fisher, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4089-4a42c694b74524d2a602b8aedc0551c248c6b33fb01e27d43e91abe8b7d1188e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>African traditional medicine</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Membrane Potentials - drug effects</topic><topic>Mitochondria - drug effects</topic><topic>mitochondrial membrane potential</topic><topic>Pilot Projects</topic><topic>Plant Extracts - pharmacology</topic><topic>reactive oxygen species</topic><topic>sperm motility</topic><topic>Sperm Motility - drug effects</topic><topic>Typha capensis</topic><topic>Typhaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henkel, R.</creatorcontrib><creatorcontrib>Fransman, W.</creatorcontrib><creatorcontrib>Hipler, U.-C.</creatorcontrib><creatorcontrib>Wiegand, C.</creatorcontrib><creatorcontrib>Schreiber, G.</creatorcontrib><creatorcontrib>Menkveld, R.</creatorcontrib><creatorcontrib>Weitz, F.</creatorcontrib><creatorcontrib>Fisher, D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henkel, R.</au><au>Fransman, W.</au><au>Hipler, U.-C.</au><au>Wiegand, C.</au><au>Schreiber, G.</au><au>Menkveld, R.</au><au>Weitz, F.</au><au>Fisher, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2012-05</date><risdate>2012</risdate><volume>44</volume><issue>s1</issue><spage>287</spage><epage>294</epage><pages>287-294</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
The biodiversity in South Africa provides more than 30 000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African traditional healers have been recognised by Law and the health benefits of T. capensis have not been scientifically investigated yet, this study aimed at investigating the in vitro effects of aqueous extracts from this plant on male reproductive functions. Both leaves and rhizomes of T. capensis were dried, infused with distilled water and freeze–dried. Motile sperm from 50 men were isolated by swim‐up and incubated with 1 μg ml−1 aqueous extract of Typha rhizome for 1 h at 37 °C. Vitality, motility, sperm production of reactive oxygen species and mitochondrial membrane potential were analysed in the test sample, a control and in the pellet from the swim‐up. Results showed that the rhizome extract had significant (P < 0.0001) negative effects on all parameters. The extracts from the leaves and rhizomes revealed dose‐dependent inhibitory activity for collagenase and free radical formation. No inhibitory activity for elastase was found. The inhibitory activity for collagenase might indicate possible anti‐cancer effects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21729138</pmid><doi>10.1111/j.1439-0272.2011.01179.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | African traditional medicine Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Humans Male Matrix Metalloproteinase Inhibitors Membrane Potentials - drug effects Mitochondria - drug effects mitochondrial membrane potential Pilot Projects Plant Extracts - pharmacology reactive oxygen species sperm motility Sperm Motility - drug effects Typha capensis Typhaceae - chemistry |
| title | Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study |
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