Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90–99% ee) via a pericyclic cascade process.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2012-06, Vol.14 (11), p.2762-2765
Hauptverfasser:	Richmond, Edward, Duguet, Nicolas, Slawin, Alexandra M. Z, Lébl, Tomáš, Smith, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Indoles - chemical synthesis Indoles - chemistry Molecular Structure Oxindoles Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism Sulfones - chemical synthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90–99% ee) via a pericyclic cascade process.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol300982f