Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus

Cdx2 expression in esophageal stem cells induced by reflux bile acids may be an important factor for development of Barrett's esophagus, whereas Notch signaling is a molecular signaling pathway that plays an important role in the determination of cell differentiation. ATOH1 (a factor associated...

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Veröffentlicht in:	Laboratory investigation 2012-06, Vol.92 (6), p.896-909
Hauptverfasser:	Tamagawa, Yuji, Ishimura, Norihisa, Uno, Goichi, Yuki, Takafumi, Kazumori, Hideaki, Ishihara, Shunji, Amano, Yuji, Kinoshita, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 631/80/86 692/699/1503/1476/1322 Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged ATOH1 Barrett Esophagus - drug therapy Barrett Esophagus - metabolism Barrett Esophagus - pathology Barrett's esophagus Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism bile acids Biological and medical sciences Biotechnology Cdx2 CDX2 Transcription Factor Cell Line, Tumor Cholic Acid - pharmacology Deoxycholic Acid - pharmacology Epithelial Cells - metabolism Epithelial Cells - pathology Esophageal Neoplasms - drug therapy Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Esophagus - metabolism Esophagus - pathology Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Gene Silencing Goblet Cells - metabolism Goblet Cells - pathology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Metaplasia Mucin-2 - genetics Mucin-2 - metabolism Notch signaling pathway Other diseases. Semiology Pathology Real-Time Polymerase Chain Reaction Receptor, Notch1 - genetics Receptor, Notch1 - metabolism research-article RNA, Small Interfering - genetics Signal Transduction Transcription Factor HES-1 Transfection
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