Multi-substituted N-phenyl-2, 2-dichloroacetamide analogues as anti-cancer drugs: design, synthesis and biological evaluation

Our earlier research has shown that mono-substituted N-phenyl-2, 2-dichloroacetamide exhibited much higher anti-cancer activity than the lead compound sodium dichloroacetate (DCA). In this paper, a variety of multi-substituted N-phenyl-2, 2-dichloroacetamides were synthesized and biologically evalua...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 2012-03, Vol.47 (3), p.354-363
Hauptverfasser:	Li, Tian-Wen, Yang, Yong-Chong, Cheng, Chang-Mei, Wang, Dong-Chun, Lu, Ai-Jun, Zhao, Yu-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - chemistry Acetamides - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Drug Design Humans Inhibitory Concentration 50 Molecular Structure Structure-Activity Relationship
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