Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis

Xiamycin A (XMA) and oxiamycin (OXM) are bacterial indolosesquiterpenes featuring rare pentacyclic ring systems and are isolated from a marine-derived Streptomyces sp. SCSIO 02999. The putative biosynthetic gene cluster for XMA/OXM was identified by a partial genome sequencing approach. Eighteen gen...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-05, Vol.134 (21), p.8996-9005
Hauptverfasser:	Li, Huixian, Zhang, Qingbo, Li, Sumei, Zhu, Yiguang, Zhang, Guangtao, Zhang, Haibo, Tian, Xinpeng, Zhang, Si, Ju, Jianhua, Zhang, Changsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Carrier Proteins - genetics Carrier Proteins - metabolism Cyclization Gene Expression Regulation, Bacterial Multigene Family Mutation Oxidation-Reduction Sesquiterpenes - metabolism Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism
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