Epigenetic silencing of the tumor suppressor klotho in human breast cancer

Klotho is a single pass transmembrane protein, associated with premature aging. We identified tumor suppressor activities for klotho, associated with reduced expression in breast cancer. We now aimed to analyze klotho expression in early stages of breast tumorigenesis and elucidate mechanisms leadin...

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Veröffentlicht in:	Breast cancer research and treatment 2012-06, Vol.133 (2), p.649-657
Hauptverfasser:	Rubinek, Tami, Shulman, Michal, Israeli, Shira, Bose, Shikha, Avraham, Ayelet, Zundelevich, Adi, Evron, Ella, Nili Gal-Yam, Einav, Kaufman, Bella, Wolf, Ido
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Analysis Azacitidine - analogs & derivatives Azacitidine - metabolism Base Sequence Biological and medical sciences Breast - metabolism Breast - pathology Breast cancer Breast Neoplasms - genetics Cancer research Cancer therapies Cell Line, Tumor CpG Islands DNA Methylation Epigenetics Female Gene Silencing Glucuronidase - genetics Gynecology. Andrology. Obstetrics Histones - metabolism Humans Immunohistochemistry Mammary gland diseases Medical sciences Medicine Medicine & Public Health Methylation Oncology Preclinical Study Promoter Regions, Genetic Proteins RNA Sulfites Tumor Suppressor Proteins - genetics Tumors
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