Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells

Nicotinamide N-methyltransferase (NNMT) was recently identified as one clear cell renal cell carcinoma (ccRCC)-associated gene by analyzing full-length complementary DNA-enriched libraries of ccRCC tissues. The aim of this study is to investigate the potential role of NNMT in cellular invasion. A st...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 2011-02, Vol.32 (2), p.138-145
Hauptverfasser:	TANG, Sai-Wen, YANG, Tsung-Cheng, LIN, Wei-Chou, CHANG, Wen-Hsin, WANG, Chung-Chieh, LAI, Ming-Kuen, LIN, Jung-Yaw
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult Aged AKT protein Animals Biological and medical sciences Carcinogenesis Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - pathology Chromatin Clear cells Diabetes mellitus Embryos Enzyme Activation Gelatinase A Humans Immunoprecipitation Invasiveness Kidney Neoplasms - enzymology Kidney Neoplasms - pathology Kidneys Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - physiology Medical sciences Metalloproteinase Metastases Mice Middle Aged Neoplasm Invasiveness Nephrology. Urinary tract diseases Nicotinamide N-methyltransferase Nicotinamide N-Methyltransferase - physiology Phosphatidylinositol 3-Kinases - physiology Promoter Regions, Genetic Promoters Proto-Oncogene Proteins c-akt - physiology renal cell carcinoma Severe combined immunodeficiency Signal transduction Sp1 protein Sp1 Transcription Factor - physiology Tumors Tumors of the urinary system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!