Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT

An increasing number of intermediate risk asymptomatic subjects benefit from measures of atherosclerosis burden like coronary artery calcification studies with non-contrast heart computed tomography (CT). However, additional information can be derived from these studies, looking beyond the coronary...

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Veröffentlicht in:Annals of biomedical engineering 2012-05, Vol.40 (5), p.1028-1038
Hauptverfasser: Craiem, Damian, Chironi, Gilles, Redheuil, Alban, Casciaro, Mariano, Mousseaux, Elie, Simon, Alain, Armentano, Ricardo L.
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container_issue 5
container_start_page 1028
container_title Annals of biomedical engineering
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creator Craiem, Damian
Chironi, Gilles
Redheuil, Alban
Casciaro, Mariano
Mousseaux, Elie
Simon, Alain
Armentano, Ricardo L.
description An increasing number of intermediate risk asymptomatic subjects benefit from measures of atherosclerosis burden like coronary artery calcification studies with non-contrast heart computed tomography (CT). However, additional information can be derived from these studies, looking beyond the coronary arteries and without exposing the patients to further radiation. We report a semi-automatic method that objectively assesses ascending, arch and descending aorta dimension and shape from non-contrast CT datasets to investigate the effect of aging on thoracic aorta geometry. First, the segmentation process identifies the vessel centerline coordinates following a toroidal path for the curvilinear portion and axial planes for descending aorta. Then, reconstructing oblique planes orthogonal to the centerline direction, it iteratively fits circles inside the vessel cross-section. Finally, regional thoracic aorta dimensions (diameter, volume and length) and shape (vessel curvature and tortuosity) are calculated. A population of 200 normotensive men was recruited. Length, mean diameter and volume differed by 1.2 cm, 0.13 cm and 21 cm 3 per decade of life, respectively. Aortic shape uncoiled with aging, reducing its tortuosity and increasing its radius of curvature. The arch was the most affected segment. In conclusion, non-contrast cardiac CT imaging can be successfully employed to assess thoracic aorta 3D morphometry.
doi_str_mv 10.1007/s10439-011-0487-y
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subjects Aging
Aging - pathology
Aorta, Thoracic - diagnostic imaging
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Classical Mechanics
Computed tomography
Coronary Angiography
Coronary Vessels
Humans
Imaging, Three-Dimensional
Male
Tomography, X-Ray Computed
title Aging Impact on Thoracic Aorta 3D Morphometry in Intermediate-Risk Subjects: Looking Beyond Coronary Arteries with Non-Contrast Cardiac CT
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