Thiopurine maintenance therapy for ulcerative colitis: The clinical significance of monitoring 6‐thioguanine nucleotide

Background: 6‐Mercaptopurine (6‐MP) is an effective maintenance medication in patients with ulcerative colitis (UC), but toxic effects like myelosuppression limit its clinical benefit. In the blood, 6‐thioguanine (6‐TGN) is formed from 6‐MP and mediates the therapeutic efficacy and most of the toxic...

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Veröffentlicht in:	Inflammatory bowel diseases 2010-08, Vol.16 (8), p.1376-1381
Hauptverfasser:	Hanai, Hiroyuki, Iida, Takayuki, Takeuchi, Ken, Arai, Osamu, Watanabe, Fumitoshi, Abe, Jinrou, Maruyama, Yasuhiko, Oohata, Akihiko, Ikeya, Kentarou, Kageoka, Masanobu, Miwa, Ichita, Yoshirou, Satou, Hosoda, Yoshisuke, Kubota, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Mercaptopurine 6‐thioguanine nucleotides Adolescent Adult Aged Body weight Bone marrow Bone Marrow - drug effects Bone Marrow Diseases - chemically induced Colitis, Ulcerative - drug therapy Drug Monitoring Enzymes Erythrocytes Erythrocytes - chemistry Erythrocytes - drug effects High-performance liquid chromatography Humans immunomodulators Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Inflammatory bowel diseases Intestine Leukapheresis Leukocytes maintenance therapy Mercaptopurine - administration & dosage Mercaptopurine - adverse effects Mercaptopurine - pharmacokinetics Mesalamine - therapeutic use Methyltransferases - analysis Methyltransferases - genetics Middle Aged Myelosuppression Nucleotides Prednisolone - therapeutic use Remission Side effects Thioguanine - blood Thiopurine S-methyltransferase Toxicity Treatment Outcome Ulcerative colitis Young Adult
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