Optimization of (Phenylmethylidene)-hydantoins as Prostate Cancer Migration Inhibitors: SAR-Directed Design, Synthesis, and Pharmacophore Modeling

Prostate cancer is one of the most common cancer forms among males of Western countries. Natural products proved to be an unparalleled source of molecular diversity. The 4‐(hydroxyphenylmethylidene)hydantoin (PMH; 1), (5Z)‐5‐(4‐hydroxybenzylidene)imidazolidine‐2,4‐dione, was isolated from the Red Se...

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Veröffentlicht in:	Chemistry & biodiversity 2011-08, Vol.8 (8), p.1470-1485
Hauptverfasser:	Mudit, Mudit, El Sayed, Khalid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Hydantoins Pharmacophore modeling Prostate cancer Structureactivity relationship (SAR)
Online-Zugang:	Volltext
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