Single-walled carbon nanotube-induced mitotic disruption

► Single-walled carbon nanotubes induce fragmented centrosomes, disrupted mitotic spindles and aneuploid chromosome number at doses possible in the workplace. ► Single-walled carbon nanotubes induce multipolar mitotic spindles. ► The increased multipolar mitotic spindles were associated with an incr...

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Veröffentlicht in:	Mutation research 2012-06, Vol.745 (1-2), p.28-37
Hauptverfasser:	Sargent, L.M., Hubbs, A.F., Young, S.-H., Kashon, M.L., Dinu, C.Z., Salisbury, J.L., Benkovic, S.A., Lowry, D.T., Murray, A.R., Kisin, E.R., Siegrist, K.J., Battelli, L., Mastovich, J., Sturgeon, J.L., Bunker, K.L., Shvedova, A.A., Reynolds, S.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploid Aneuploidy Carbon Cell Cycle - drug effects Cell division Cell proliferation Cell Survival - drug effects Cells Cells, Cultured Centrosomes Chromatin Chromosome number Chromosomes Colonies Cytotoxicity Epithelial cells G2 phase Genotoxicity Humans Lung cancer Microtubules Mitosis - drug effects Mitotic spindle Nanoparticles nanotechnology Nanotoxicology Nanotubes Nanotubes, Carbon - toxicity Occupational exposure Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory tract Solid tumors Spindle Apparatus - drug effects Spindles Tumorigenesis
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