Optimizing potentiometric ionophore and electrode design for environmental on-site control of antibiotic drugs: Application to sulfamethoxazole
▸ Plastic antibodies designed by surface imprint on graphitic carbon nanostructures. ▸ An electrical-based sensor made from pipette tips. ▸ On-site detection of organic drugs. Potentiometric sensors are typically unable to carry out on-site monitoring of environmental drug contaminants because of th...
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| Veröffentlicht in: | Biosensors & bioelectronics 2012-05, Vol.35 (1), p.319-326 |
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| creator | Almeida, S.A.A. Truta, Liliana A.A.N.A. Queirós, Raquel B. Montenegro, M.C.B.S.M. Cunha, Alexandre L. Sales, M.G.F. |
| description | ▸ Plastic antibodies designed by surface imprint on graphitic carbon nanostructures. ▸ An electrical-based sensor made from pipette tips. ▸ On-site detection of organic drugs.
Potentiometric sensors are typically unable to carry out on-site monitoring of environmental drug contaminants because of their high limits of detection (LODs). Designing a novel ligand material for the target analyte and managing the composition of the internal reference solution have been the strategies employed here to produce for the first time a potentiometric-based direct reading method for an environmental drug contaminant. This concept has been applied to sulfamethoxazole (SMX), one of the many antibiotics used in aquaculture practices that may occur in environmental waters.
The novel ligand has been produced by imprinting SMX on the surface of graphitic carbon nanostructures (CN) |
| doi_str_mv | 10.1016/j.bios.2012.03.007 |
| format | Article |
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Potentiometric sensors are typically unable to carry out on-site monitoring of environmental drug contaminants because of their high limits of detection (LODs). Designing a novel ligand material for the target analyte and managing the composition of the internal reference solution have been the strategies employed here to produce for the first time a potentiometric-based direct reading method for an environmental drug contaminant. This concept has been applied to sulfamethoxazole (SMX), one of the many antibiotics used in aquaculture practices that may occur in environmental waters.
The novel ligand has been produced by imprinting SMX on the surface of graphitic carbon nanostructures (CN)<500nm. The imprinted carbon nanostructures (ICN) were dispersed in plasticizer and entrapped in a PVC matrix that included (or not) a small amount of a lipophilic additive. The membrane composition was optimized on solid-contact electrodes, allowing near-Nernstian responses down to 5.2μg/mL and detecting 1.6μg/mL. The membranes offered good selectivity against most of the ionic compounds in environmental water.
The best membrane cocktail was applied on the smaller end of a 1000μL micropipette tip made of polypropylene. The tip was then filled with inner reference solution containing SMX and chlorate (as interfering compound). The corresponding concentrations were studied for 1×10−5 to 1×10−10 and 1×10−3 to 1×10−8mol/L. The best condition allowed the detection of 5.92ng/L (or 2.3×10−8mol/L) SMX for a sub-Nernstian slope of −40.3mV/decade from 5.0×10−8 to 2.4×10−5mol/L.
The described sensors were found promising devices for field applications. The good selectivity of the sensory materials together with a carefully selected composition for the inner reference solution allowed LODs near the nanomolar range. Both solid-contact and “pipette tip”-based sensors were successfully applied to the analysis of aquaculture waters.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2012.03.007</identifier><identifier>PMID: 22465445</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - analysis ; Antibiotic contaminants ; Aquaculture ; Biological and medical sciences ; Biosensing Techniques - instrumentation ; Biosensing Techniques - methods ; Biosensing Techniques - statistics & numerical data ; Biotechnology ; Electrodes ; Equipment Design ; Fundamental and applied biological sciences. Psychology ; Hydrogen-Ion Concentration ; Ionophores ; Limit of Detection ; Low detection limit ; Molecular Imprinting ; Nanotubes, Carbon ; Plastic antibodies ; Potentiometry ; Potentiometry - instrumentation ; Potentiometry - methods ; Potentiometry - statistics & numerical data ; Solid-contact electrodes ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Sulfamethoxazole - analysis ; Water Pollutants, Chemical - analysis</subject><ispartof>Biosensors & bioelectronics, 2012-05, Vol.35 (1), p.319-326</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-f0bdb62499663f46ee1278235c2bc4142a1418f040a889acef38b08c23c37593</citedby><cites>FETCH-LOGICAL-c491t-f0bdb62499663f46ee1278235c2bc4142a1418f040a889acef38b08c23c37593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S095656631200173X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25919255$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22465445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida, S.A.A.</creatorcontrib><creatorcontrib>Truta, Liliana A.A.N.A.</creatorcontrib><creatorcontrib>Queirós, Raquel B.</creatorcontrib><creatorcontrib>Montenegro, M.C.B.S.M.</creatorcontrib><creatorcontrib>Cunha, Alexandre L.</creatorcontrib><creatorcontrib>Sales, M.G.F.</creatorcontrib><title>Optimizing potentiometric ionophore and electrode design for environmental on-site control of antibiotic drugs: Application to sulfamethoxazole</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>▸ Plastic antibodies designed by surface imprint on graphitic carbon nanostructures. ▸ An electrical-based sensor made from pipette tips. ▸ On-site detection of organic drugs.
Potentiometric sensors are typically unable to carry out on-site monitoring of environmental drug contaminants because of their high limits of detection (LODs). Designing a novel ligand material for the target analyte and managing the composition of the internal reference solution have been the strategies employed here to produce for the first time a potentiometric-based direct reading method for an environmental drug contaminant. This concept has been applied to sulfamethoxazole (SMX), one of the many antibiotics used in aquaculture practices that may occur in environmental waters.
The novel ligand has been produced by imprinting SMX on the surface of graphitic carbon nanostructures (CN)<500nm. The imprinted carbon nanostructures (ICN) were dispersed in plasticizer and entrapped in a PVC matrix that included (or not) a small amount of a lipophilic additive. The membrane composition was optimized on solid-contact electrodes, allowing near-Nernstian responses down to 5.2μg/mL and detecting 1.6μg/mL. The membranes offered good selectivity against most of the ionic compounds in environmental water.
The best membrane cocktail was applied on the smaller end of a 1000μL micropipette tip made of polypropylene. The tip was then filled with inner reference solution containing SMX and chlorate (as interfering compound). The corresponding concentrations were studied for 1×10−5 to 1×10−10 and 1×10−3 to 1×10−8mol/L. The best condition allowed the detection of 5.92ng/L (or 2.3×10−8mol/L) SMX for a sub-Nernstian slope of −40.3mV/decade from 5.0×10−8 to 2.4×10−5mol/L.
The described sensors were found promising devices for field applications. The good selectivity of the sensory materials together with a carefully selected composition for the inner reference solution allowed LODs near the nanomolar range. Both solid-contact and “pipette tip”-based sensors were successfully applied to the analysis of aquaculture waters.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Antibiotic contaminants</subject><subject>Aquaculture</subject><subject>Biological and medical sciences</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensing Techniques - methods</subject><subject>Biosensing Techniques - statistics & numerical data</subject><subject>Biotechnology</subject><subject>Electrodes</subject><subject>Equipment Design</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Ionophores</subject><subject>Limit of Detection</subject><subject>Low detection limit</subject><subject>Molecular Imprinting</subject><subject>Nanotubes, Carbon</subject><subject>Plastic antibodies</subject><subject>Potentiometry</subject><subject>Potentiometry - instrumentation</subject><subject>Potentiometry - methods</subject><subject>Potentiometry - statistics & numerical data</subject><subject>Solid-contact electrodes</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spectrum Analysis, Raman</subject><subject>Sulfamethoxazole - analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhBVggb5DYJPgvTozYVBV_UqVuurcc53rqUWIH26mgL8Er49EMsGNlWfrOufeeg9BrSlpKqHx_aEcfc8sIZS3hLSH9E7SjQ88bwXj3FO2I6mTTSckv0IucD6QSVJHn6IIxITshuh36dbsWv_hHH_Z4jQVC8XGBkrzFPoa43scE2IQJwwy2pDgBniD7fcAuJgzhwacYliozM46hyb4AtjFUsv5dVRZflyzVbkrbPn_AV-s6e2vqmIBLxHmbnakD7-MP8xhneImeOTNneHV-L9Hd509311-bm9sv366vbhorFC2NI-M0SiaUqtc5IQEo64d6tWWjFVQwQwUdHBHEDIMyFhwfRjJYxi3vO8Uv0buT7Zri9w1y0YvPFubZBIhb1jXfXvU94bKi7ITaFHNO4PSa_GLSzwodOakP-tiDPvagCdc15Sp6c_bfxgWmv5I_wVfg7Rkw2ZrZJROsz_-4TlHFuiP38cRBDePBQ9LZeggWJp9qIXqK_n97_AYBb6n1</recordid><startdate>20120515</startdate><enddate>20120515</enddate><creator>Almeida, S.A.A.</creator><creator>Truta, Liliana A.A.N.A.</creator><creator>Queirós, Raquel B.</creator><creator>Montenegro, M.C.B.S.M.</creator><creator>Cunha, Alexandre L.</creator><creator>Sales, M.G.F.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120515</creationdate><title>Optimizing potentiometric ionophore and electrode design for environmental on-site control of antibiotic drugs: Application to sulfamethoxazole</title><author>Almeida, S.A.A. ; Truta, Liliana A.A.N.A. ; Queirós, Raquel B. ; Montenegro, M.C.B.S.M. ; Cunha, Alexandre L. ; Sales, M.G.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-f0bdb62499663f46ee1278235c2bc4142a1418f040a889acef38b08c23c37593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Antibiotic contaminants</topic><topic>Aquaculture</topic><topic>Biological and medical sciences</topic><topic>Biosensing Techniques - instrumentation</topic><topic>Biosensing Techniques - methods</topic><topic>Biosensing Techniques - statistics & numerical data</topic><topic>Biotechnology</topic><topic>Electrodes</topic><topic>Equipment Design</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Ionophores</topic><topic>Limit of Detection</topic><topic>Low detection limit</topic><topic>Molecular Imprinting</topic><topic>Nanotubes, Carbon</topic><topic>Plastic antibodies</topic><topic>Potentiometry</topic><topic>Potentiometry - instrumentation</topic><topic>Potentiometry - methods</topic><topic>Potentiometry - statistics & numerical data</topic><topic>Solid-contact electrodes</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Spectrum Analysis, Raman</topic><topic>Sulfamethoxazole - analysis</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almeida, S.A.A.</creatorcontrib><creatorcontrib>Truta, Liliana A.A.N.A.</creatorcontrib><creatorcontrib>Queirós, Raquel B.</creatorcontrib><creatorcontrib>Montenegro, M.C.B.S.M.</creatorcontrib><creatorcontrib>Cunha, Alexandre L.</creatorcontrib><creatorcontrib>Sales, M.G.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almeida, S.A.A.</au><au>Truta, Liliana A.A.N.A.</au><au>Queirós, Raquel B.</au><au>Montenegro, M.C.B.S.M.</au><au>Cunha, Alexandre L.</au><au>Sales, M.G.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimizing potentiometric ionophore and electrode design for environmental on-site control of antibiotic drugs: Application to sulfamethoxazole</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2012-05-15</date><risdate>2012</risdate><volume>35</volume><issue>1</issue><spage>319</spage><epage>326</epage><pages>319-326</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>▸ Plastic antibodies designed by surface imprint on graphitic carbon nanostructures. ▸ An electrical-based sensor made from pipette tips. ▸ On-site detection of organic drugs.
Potentiometric sensors are typically unable to carry out on-site monitoring of environmental drug contaminants because of their high limits of detection (LODs). Designing a novel ligand material for the target analyte and managing the composition of the internal reference solution have been the strategies employed here to produce for the first time a potentiometric-based direct reading method for an environmental drug contaminant. This concept has been applied to sulfamethoxazole (SMX), one of the many antibiotics used in aquaculture practices that may occur in environmental waters.
The novel ligand has been produced by imprinting SMX on the surface of graphitic carbon nanostructures (CN)<500nm. The imprinted carbon nanostructures (ICN) were dispersed in plasticizer and entrapped in a PVC matrix that included (or not) a small amount of a lipophilic additive. The membrane composition was optimized on solid-contact electrodes, allowing near-Nernstian responses down to 5.2μg/mL and detecting 1.6μg/mL. The membranes offered good selectivity against most of the ionic compounds in environmental water.
The best membrane cocktail was applied on the smaller end of a 1000μL micropipette tip made of polypropylene. The tip was then filled with inner reference solution containing SMX and chlorate (as interfering compound). The corresponding concentrations were studied for 1×10−5 to 1×10−10 and 1×10−3 to 1×10−8mol/L. The best condition allowed the detection of 5.92ng/L (or 2.3×10−8mol/L) SMX for a sub-Nernstian slope of −40.3mV/decade from 5.0×10−8 to 2.4×10−5mol/L.
The described sensors were found promising devices for field applications. The good selectivity of the sensory materials together with a carefully selected composition for the inner reference solution allowed LODs near the nanomolar range. Both solid-contact and “pipette tip”-based sensors were successfully applied to the analysis of aquaculture waters.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22465445</pmid><doi>10.1016/j.bios.2012.03.007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Bacterial Agents - analysis Antibiotic contaminants Aquaculture Biological and medical sciences Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensing Techniques - statistics & numerical data Biotechnology Electrodes Equipment Design Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Ionophores Limit of Detection Low detection limit Molecular Imprinting Nanotubes, Carbon Plastic antibodies Potentiometry Potentiometry - instrumentation Potentiometry - methods Potentiometry - statistics & numerical data Solid-contact electrodes Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Sulfamethoxazole - analysis Water Pollutants, Chemical - analysis |
| title | Optimizing potentiometric ionophore and electrode design for environmental on-site control of antibiotic drugs: Application to sulfamethoxazole |
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