Whole blood flow cytometric measurement of NFATc1 and IL-2 expression to analyze cyclosporine A-mediated effects in T cells

The calcineurin inhibitor Cyclosporine A (CsA) is one of the crucial immunosuppressive drugs given after organ transplantation. The small therapeutic window of CsA generates the dilemma that efficient and toxic drug doses differ only slightly. Moreover, these threshold concentrations differ consider...

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Veröffentlicht in:	Cytometry. Part A 2010-07, Vol.77A (7), p.607-613
Hauptverfasser:	Brandt, Claudia, Liman, Peter, Bendfeldt, Hanna, Mueller, Karin, Reinke, Petra, Radbruch, Andreas, Worm, Margitta, Baumgrass, Ria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biomarkers Biomarkers - metabolism Blood Preservation - methods calcineurin calcineurin inhibitors CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cyclosporine - pharmacology cyclosporine A Cyclosporins drug monitoring Flow cytometry Flow Cytometry - methods Flow Cytometry - standards Humans Immunosuppressive agents Immunosuppressive Agents - pharmacology Interleukin 2 Interleukin-2 - blood Interleukin-2 - immunology Ionomycin - pharmacology Ionophores - pharmacology Lymphocytes T NFAT NFATC Transcription Factors - blood NFATC Transcription Factors - immunology Reproducibility of Results Tetradecanoylphorbol Acetate - pharmacology Toxicity transcription factor Transcription factors whole blood stimulation
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