Downregulation of CD40 Signal and Induction of TGF-β by Phosphatidylinositol Mediates Reduction in Immunogenicity Against Recombinant Human Factor VIII

Factor VIII (FVIII) is an important coagulation cofactor and its deficiency causes Hemophilia A, a bleeding disorder. Replacement therapy using recombinant FVIII is currently the first line of therapy for Hemophilia A, but the development of neutralizing antibody is a major clinical complication for...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2012-01, Vol.101 (1), p.48-55
Hauptverfasser:	Gaitonde, Puneet, Peng, Aaron, Straubinger, Robert M., Bankert, Richard B., Balu-iyer, Sathy V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - immunology Antibody response Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - metabolism Biological and medical sciences Biotechnology Bleeding CD40 antigen CD40 Antigens - immunology CD40 Antigens - metabolism Cell-culture Cells, Cultured Co-stimulatory signal Coagulation Coagulation factors Cofactors Data processing Dendritic cell Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Down-Regulation - drug effects Down-Regulation - immunology Factor VIII - immunology Factor VIII - metabolism Factor VIII - pharmacology General pharmacology Hemophilia Humans Immunogenicity Immunology Inflammation Interleukin 10 Interleukin 17 Interleukin 6 Interleukins - metabolism Interleukins - secretion Medical sciences Mice Mice, Inbred C57BL Nanoparticle nanoparticles Nanoparticles - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments phosphatidylinositol Phosphatidylinositols - immunology Phosphatidylinositols - pharmacology Phospholipids Recombinant Proteins - immunology Recombinant Proteins - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Therapeutic protein Transforming growth factor Transforming Growth Factor beta1 - immunology Transforming Growth Factor beta1 - metabolism Transforming Growth Factor-β Up-Regulation - drug effects Up-Regulation - immunology
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