Primary B-CLL Resistance to NK Cell Cytotoxicity can be Overcome In Vitro and In Vivo by Priming NK Cells and Monoclonal Antibody Therapy

Despite recent advances with monoclonal antibody therapy, chronic lymphocytic leukemia (CLL) remains incurable. Natural killer (NK) cells are potent antitumoral effectors, particularly against hematological malignancies. Defective recognition of B-CLL leukemic cells by NK cells has been previously d...

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Veröffentlicht in:	Journal of clinical immunology 2012-06, Vol.32 (3), p.632-646
Hauptverfasser:	Veuillen, Caroline, Aurran-Schleinitz, Thérèse, Castellano, Rémy, Rey, Jérôme, Mallet, Françoise, Orlanducci, Florence, Pouyet, Laurent, Just-Landi, Sylvaine, Coso, Diane, Ivanov, Vadim, Carcopino, Xavier, Bouabdallah, Réda, Collette, Yves, Fauriat, Cyril, Olive, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animal models Animals Antibodies, Monoclonal, Murine-Derived - pharmacology Biomedical and Life Sciences Biomedicine Cell interactions Cell recognition Chronic lymphatic leukemia Cytotoxicity Data processing Histocompatibility Antigens Class I - immunology HLA-E Antigens Humans Immune system Immunologic Factors - pharmacology Immunology Infectious Diseases Internal Medicine Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Lymphocytes B Male Malignancy Medical Microbiology Mice Mice, Inbred NOD Mice, SCID Middle Aged Monoclonal antibodies Natural Cytotoxicity Triggering Receptor 3 - immunology Natural killer cells Neoplasm Transplantation Rituximab Synergism Tumors Xenografts
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