Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats

This study examined the possible protective effects of thymoquinone (TQ), the main constituent of the volatile oil of black seed (Nigella sativa), against cyclophosphamide (CP)‐induced cardiotoxicity. Adult male Wistar albino rats were divided into four treatment groups. Rats in the first group were...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2011-05, Vol.25 (3), p.135-142
Hauptverfasser:	Nagi, Mahmoud N., Al-Shabanah, Othman A., Hafez, Mohamed M., Sayed-Ahmed, Mohamed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Adenosine Triphosphate - metabolism Animals Antioxidants ATP Benzoquinones - therapeutic use Cardiotoxicity Catalase Cholesterol Cholesterol - blood Creatine Creatine kinase Creatine Kinase, MB Form - blood Creatinine Creatinine - blood Cyclophosphamide Cyclophosphamide - antagonists & inhibitors Cyclophosphamide - toxicity Data processing Dietary Supplements Drinking water Enzymes Glutathione Glutathione - metabolism Glutathione peroxidase Heart Heart Diseases - blood Heart Diseases - chemically induced Heart Diseases - drug therapy Heart Diseases - prevention & control Internet Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood Lactate dehydrogenase Male Mitochondria Myocardium - enzymology Myocardium - pathology Nigella sativa Nitrate Nitrates - metabolism Nitrites - metabolism Nitrosative Stress Oil Oxidative Stress Peroxidase Rats Rats, Wistar Seeds Stress Supplementation Supplements Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Thymoquinone Triglycerides Triglycerides - blood Tumor Necrosis Factor-alpha - blood Urea Urea - blood Volatiles
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