Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice
Background Aspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in...
Gespeichert in:
| Veröffentlicht in: | American journal of industrial medicine 2010-12, Vol.53 (12), p.1197-1206 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1206 |
|---|---|
| container_issue | 12 |
| container_start_page | 1197 |
| container_title | American journal of industrial medicine |
| container_volume | 53 |
| creator | Soffritti, Morando Belpoggi, Fiorella Manservigi, Marco Tibaldi, Eva Lauriola, Michelina Falcioni, Laura Bua, Luciano |
| description | Background
Aspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.
Objective
The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.
Methods
Six groups of 62–122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.
Results
APM in our experimental conditions induces in males a significant dose‐related increased incidence of hepatocellular carcinomas (P |
| doi_str_mv | 10.1002/ajim.20896 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1017966663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017966663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4296-b82bff6cdd76af6f74613d696ceb9979d63aeba43e26c7405a010e5132d2ed763</originalsourceid><addsrcrecordid>eNp9kU9v1DAUxC0EotvChQ-AfEFCVVP8J7E3x6WCUmgBqUU9Wo79vHVxnMVOKHvjo-Nlt-XGu7zLb2akGYReUHJMCWFv9K3vjxmZt-IRmlHSyoowWT9Gs_JoxZu52EP7Od8SQmkt6qdor8Bz0XAyQ78XeaXTqHvA2vY--jxCAot9xA7AHuEOlj5GH5d4lSDqUYewxuNNGqblDQ7eAS4G8agI7GQgY6OjgZTx4AoFhfgJCetocZiKR7HtdQB8eedzxr038Aw9cTpkeL77B-jb-3dXJx-q8y-nZyeL88rUrBVVN2edc8JYK4V2wslaUG5FKwx0bStbK7iGTtccmDCyJo0mlEBDObMMioYfoNdb31UafkyQR9X7bCAEHWGYsqKEylaU4wU93KImDTkncGqVfK_TukBq07jaNK7-Nl7glzvfqevBPqD3FRfg1Q7Q2ejgUinI538cL5NIvkmlW-7OB1j_J1ItPp5d3IdXW81mtl8PGp2-KyG5bNT151N1LS-uLt9-ZeoT_wPwLKj8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017966663</pqid></control><display><type>article</type><title>Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Soffritti, Morando ; Belpoggi, Fiorella ; Manservigi, Marco ; Tibaldi, Eva ; Lauriola, Michelina ; Falcioni, Laura ; Bua, Luciano</creator><creatorcontrib>Soffritti, Morando ; Belpoggi, Fiorella ; Manservigi, Marco ; Tibaldi, Eva ; Lauriola, Michelina ; Falcioni, Laura ; Bua, Luciano</creatorcontrib><description>Background
Aspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.
Objective
The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.
Methods
Six groups of 62–122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.
Results
APM in our experimental conditions induces in males a significant dose‐related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000 ppm (P < 0.01) and 16,000 ppm (P < 0.05). Moreover, the results show a significant dose‐related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000 ppm (P < 0.05).
Conclusions
The results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197–1206, 2010. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>ISSN: 1097-0274</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.20896</identifier><identifier>PMID: 20886530</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Age Factors ; Animals ; artificial sweeteners ; aspartame ; Aspartame - administration & dosage ; Aspartame - adverse effects ; Biological and medical sciences ; cancers ; Carcinogenesis, carcinogens and anticarcinogens ; carcinogenicity ; Carcinogens ; Chemical agents ; Female ; Food Supply ; Gastroenterology. Liver. Pancreas. Abdomen ; hepatocarcinomas ; Liver Neoplasms - etiology ; Liver Neoplasms - pathology ; Liver Neoplasms - veterinary ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; lung adenocarcinomas ; Lung Neoplasms - etiology ; Lung Neoplasms - pathology ; Lung Neoplasms - veterinary ; Male ; Medical sciences ; Mice ; Pneumology ; Pregnancy ; prenatal exposure ; Prenatal Exposure Delayed Effects - etiology ; Prenatal Exposure Delayed Effects - pathology ; Prenatal Exposure Delayed Effects - veterinary ; Proportional Hazards Models ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Sweetening Agents - administration & dosage ; Sweetening Agents - adverse effects ; Swiss mice ; Time Factors ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>American journal of industrial medicine, 2010-12, Vol.53 (12), p.1197-1206</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4296-b82bff6cdd76af6f74613d696ceb9979d63aeba43e26c7405a010e5132d2ed763</citedby><cites>FETCH-LOGICAL-c4296-b82bff6cdd76af6f74613d696ceb9979d63aeba43e26c7405a010e5132d2ed763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.20896$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.20896$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23464733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20886530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soffritti, Morando</creatorcontrib><creatorcontrib>Belpoggi, Fiorella</creatorcontrib><creatorcontrib>Manservigi, Marco</creatorcontrib><creatorcontrib>Tibaldi, Eva</creatorcontrib><creatorcontrib>Lauriola, Michelina</creatorcontrib><creatorcontrib>Falcioni, Laura</creatorcontrib><creatorcontrib>Bua, Luciano</creatorcontrib><title>Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
Aspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.
Objective
The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.
Methods
Six groups of 62–122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.
Results
APM in our experimental conditions induces in males a significant dose‐related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000 ppm (P < 0.01) and 16,000 ppm (P < 0.05). Moreover, the results show a significant dose‐related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000 ppm (P < 0.05).
Conclusions
The results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197–1206, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Age Factors</subject><subject>Animals</subject><subject>artificial sweeteners</subject><subject>aspartame</subject><subject>Aspartame - administration & dosage</subject><subject>Aspartame - adverse effects</subject><subject>Biological and medical sciences</subject><subject>cancers</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>carcinogenicity</subject><subject>Carcinogens</subject><subject>Chemical agents</subject><subject>Female</subject><subject>Food Supply</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>hepatocarcinomas</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - veterinary</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>lung adenocarcinomas</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - veterinary</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pneumology</subject><subject>Pregnancy</subject><subject>prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - etiology</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>Prenatal Exposure Delayed Effects - veterinary</subject><subject>Proportional Hazards Models</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sweetening Agents - administration & dosage</subject><subject>Sweetening Agents - adverse effects</subject><subject>Swiss mice</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0271-3586</issn><issn>1097-0274</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAUxC0EotvChQ-AfEFCVVP8J7E3x6WCUmgBqUU9Wo79vHVxnMVOKHvjo-Nlt-XGu7zLb2akGYReUHJMCWFv9K3vjxmZt-IRmlHSyoowWT9Gs_JoxZu52EP7Od8SQmkt6qdor8Bz0XAyQ78XeaXTqHvA2vY--jxCAot9xA7AHuEOlj5GH5d4lSDqUYewxuNNGqblDQ7eAS4G8agI7GQgY6OjgZTx4AoFhfgJCetocZiKR7HtdQB8eedzxr038Aw9cTpkeL77B-jb-3dXJx-q8y-nZyeL88rUrBVVN2edc8JYK4V2wslaUG5FKwx0bStbK7iGTtccmDCyJo0mlEBDObMMioYfoNdb31UafkyQR9X7bCAEHWGYsqKEylaU4wU93KImDTkncGqVfK_TukBq07jaNK7-Nl7glzvfqevBPqD3FRfg1Q7Q2ejgUinI538cL5NIvkmlW-7OB1j_J1ItPp5d3IdXW81mtl8PGp2-KyG5bNT151N1LS-uLt9-ZeoT_wPwLKj8</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Soffritti, Morando</creator><creator>Belpoggi, Fiorella</creator><creator>Manservigi, Marco</creator><creator>Tibaldi, Eva</creator><creator>Lauriola, Michelina</creator><creator>Falcioni, Laura</creator><creator>Bua, Luciano</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201012</creationdate><title>Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice</title><author>Soffritti, Morando ; Belpoggi, Fiorella ; Manservigi, Marco ; Tibaldi, Eva ; Lauriola, Michelina ; Falcioni, Laura ; Bua, Luciano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4296-b82bff6cdd76af6f74613d696ceb9979d63aeba43e26c7405a010e5132d2ed763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>artificial sweeteners</topic><topic>aspartame</topic><topic>Aspartame - administration & dosage</topic><topic>Aspartame - adverse effects</topic><topic>Biological and medical sciences</topic><topic>cancers</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>carcinogenicity</topic><topic>Carcinogens</topic><topic>Chemical agents</topic><topic>Female</topic><topic>Food Supply</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>hepatocarcinomas</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - veterinary</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>lung adenocarcinomas</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - veterinary</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pneumology</topic><topic>Pregnancy</topic><topic>prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects - etiology</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>Prenatal Exposure Delayed Effects - veterinary</topic><topic>Proportional Hazards Models</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sweetening Agents - administration & dosage</topic><topic>Sweetening Agents - adverse effects</topic><topic>Swiss mice</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soffritti, Morando</creatorcontrib><creatorcontrib>Belpoggi, Fiorella</creatorcontrib><creatorcontrib>Manservigi, Marco</creatorcontrib><creatorcontrib>Tibaldi, Eva</creatorcontrib><creatorcontrib>Lauriola, Michelina</creatorcontrib><creatorcontrib>Falcioni, Laura</creatorcontrib><creatorcontrib>Bua, Luciano</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soffritti, Morando</au><au>Belpoggi, Fiorella</au><au>Manservigi, Marco</au><au>Tibaldi, Eva</au><au>Lauriola, Michelina</au><au>Falcioni, Laura</au><au>Bua, Luciano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2010-12</date><risdate>2010</risdate><volume>53</volume><issue>12</issue><spage>1197</spage><epage>1206</epage><pages>1197-1206</pages><issn>0271-3586</issn><issn>1097-0274</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
Aspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.
Objective
The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.
Methods
Six groups of 62–122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.
Results
APM in our experimental conditions induces in males a significant dose‐related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000 ppm (P < 0.01) and 16,000 ppm (P < 0.05). Moreover, the results show a significant dose‐related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000 ppm (P < 0.05).
Conclusions
The results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197–1206, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20886530</pmid><doi>10.1002/ajim.20896</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-3586 |
| ispartof | American journal of industrial medicine, 2010-12, Vol.53 (12), p.1197-1206 |
| issn | 0271-3586 1097-0274 1097-0274 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1017966663 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Factors Animals artificial sweeteners aspartame Aspartame - administration & dosage Aspartame - adverse effects Biological and medical sciences cancers Carcinogenesis, carcinogens and anticarcinogens carcinogenicity Carcinogens Chemical agents Female Food Supply Gastroenterology. Liver. Pancreas. Abdomen hepatocarcinomas Liver Neoplasms - etiology Liver Neoplasms - pathology Liver Neoplasms - veterinary Liver. Biliary tract. Portal circulation. Exocrine pancreas lung adenocarcinomas Lung Neoplasms - etiology Lung Neoplasms - pathology Lung Neoplasms - veterinary Male Medical sciences Mice Pneumology Pregnancy prenatal exposure Prenatal Exposure Delayed Effects - etiology Prenatal Exposure Delayed Effects - pathology Prenatal Exposure Delayed Effects - veterinary Proportional Hazards Models Random Allocation Rats Rats, Sprague-Dawley Sweetening Agents - administration & dosage Sweetening Agents - adverse effects Swiss mice Time Factors Tumors Tumors of the respiratory system and mediastinum |
| title | Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T10%3A35%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aspartame%20administered%20in%20feed,%20beginning%20prenatally%20through%20life%20span,%20induces%20cancers%20of%20the%20liver%20and%20lung%20in%20male%20Swiss%20mice&rft.jtitle=American%20journal%20of%20industrial%20medicine&rft.au=Soffritti,%20Morando&rft.date=2010-12&rft.volume=53&rft.issue=12&rft.spage=1197&rft.epage=1206&rft.pages=1197-1206&rft.issn=0271-3586&rft.eissn=1097-0274&rft.coden=AJIMD8&rft_id=info:doi/10.1002/ajim.20896&rft_dat=%3Cproquest_cross%3E1017966663%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1017966663&rft_id=info:pmid/20886530&rfr_iscdi=true |