A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester
BACKGROUND: The focus of this paper is the ultrasound‐assisted synthesis of caffeic acid phenethyl ester (CAPE) from caffeic acid and phenyl ethanol in a continuous packed‐bed bioreactor. Immobilized Novozym® 435 (from Candida antarctica) is used as the catalyst. A three‐level–three‐factor Box–Behnk...
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| Veröffentlicht in: | Journal of chemical technology and biotechnology (1986) 2011-10, Vol.86 (10), p.1289-1294 |
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| container_issue | 10 |
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| container_title | Journal of chemical technology and biotechnology (1986) |
| container_volume | 86 |
| creator | Chen, Hsiao-Ching Kuo, Chia-Hung Twu, Yawo-Kuo Chen, Jiann-Hwa Chang, Chieh-Ming J. Liu, Yung-Chuan Shieh, Chwen-Jen |
| description | BACKGROUND: The focus of this paper is the ultrasound‐assisted synthesis of caffeic acid phenethyl ester (CAPE) from caffeic acid and phenyl ethanol in a continuous packed‐bed bioreactor. Immobilized Novozym® 435 (from Candida antarctica) is used as the catalyst. A three‐level–three‐factor Box–Behnken design and a response surface methodology (RSM) are employed to evaluate the effects of temperature, flow rate, and ultrasonic power on the percentage molar conversion of CAPE.
RESULTS: Based on ridge max analysis, it is concluded that the optimum condition for synthesis is reaction temperature 72.66 °C, flow rate 0.046 mL min−1, and ultrasonic power 1.64 W cm−2. The expected molar conversion value is 97.84%. An experiment performed under these optimal conditions resulted in a molar conversion of 92.11 ± 0.75%. The enzyme in the bioreactor was found to be stable for at least 6 days.
CONCLUSIONS: The lipase‐catalyzed synthesis of CAPE by an ultrasound‐assisted packed‐bed bioreactor uses mild reaction conditions. Enzymatic synthesis of CAPE is suitable for use in the nutraceutical and food production industries. Copyright © 2011 Society of Chemical Industry |
| doi_str_mv | 10.1002/jctb.2661 |
| format | Article |
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RESULTS: Based on ridge max analysis, it is concluded that the optimum condition for synthesis is reaction temperature 72.66 °C, flow rate 0.046 mL min−1, and ultrasonic power 1.64 W cm−2. The expected molar conversion value is 97.84%. An experiment performed under these optimal conditions resulted in a molar conversion of 92.11 ± 0.75%. The enzyme in the bioreactor was found to be stable for at least 6 days.
CONCLUSIONS: The lipase‐catalyzed synthesis of CAPE by an ultrasound‐assisted packed‐bed bioreactor uses mild reaction conditions. Enzymatic synthesis of CAPE is suitable for use in the nutraceutical and food production industries. Copyright © 2011 Society of Chemical Industry</description><identifier>ISSN: 0268-2575</identifier><identifier>ISSN: 1097-4660</identifier><identifier>EISSN: 1097-4660</identifier><identifier>DOI: 10.1002/jctb.2661</identifier><identifier>CODEN: JCTBDC</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Applied sciences ; Biological and medical sciences ; Bioreactors ; Biotechnology ; Catalysis ; Catalytic reactions ; Chemical engineering ; Chemistry ; Conversion ; Esters ; Ethyl alcohol ; Exact sciences and technology ; Flow rate ; Food engineering ; Food industries ; Fundamental and applied biological sciences. Psychology ; General and physical chemistry ; General aspects ; lipase ; Methods. Procedures. Technologies ; Optimization ; Others ; packed-bed reactor ; phenolic acid ; Phenyls ; Reactors ; response surface methodology ; Synthesis ; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry ; ultrasonication ; Various methods and equipments</subject><ispartof>Journal of chemical technology and biotechnology (1986), 2011-10, Vol.86 (10), p.1289-1294</ispartof><rights>Copyright © 2011 Society of Chemical Industry</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4071-fbba618372d5d609041045c01625cd4fe2a3058e1494d836a57bba0485625af33</citedby><cites>FETCH-LOGICAL-c4071-fbba618372d5d609041045c01625cd4fe2a3058e1494d836a57bba0485625af33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjctb.2661$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjctb.2661$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24540272$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hsiao-Ching</creatorcontrib><creatorcontrib>Kuo, Chia-Hung</creatorcontrib><creatorcontrib>Twu, Yawo-Kuo</creatorcontrib><creatorcontrib>Chen, Jiann-Hwa</creatorcontrib><creatorcontrib>Chang, Chieh-Ming J.</creatorcontrib><creatorcontrib>Liu, Yung-Chuan</creatorcontrib><creatorcontrib>Shieh, Chwen-Jen</creatorcontrib><title>A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester</title><title>Journal of chemical technology and biotechnology (1986)</title><addtitle>J. Chem. Technol. Biotechnol</addtitle><description>BACKGROUND: The focus of this paper is the ultrasound‐assisted synthesis of caffeic acid phenethyl ester (CAPE) from caffeic acid and phenyl ethanol in a continuous packed‐bed bioreactor. Immobilized Novozym® 435 (from Candida antarctica) is used as the catalyst. A three‐level–three‐factor Box–Behnken design and a response surface methodology (RSM) are employed to evaluate the effects of temperature, flow rate, and ultrasonic power on the percentage molar conversion of CAPE.
RESULTS: Based on ridge max analysis, it is concluded that the optimum condition for synthesis is reaction temperature 72.66 °C, flow rate 0.046 mL min−1, and ultrasonic power 1.64 W cm−2. The expected molar conversion value is 97.84%. An experiment performed under these optimal conditions resulted in a molar conversion of 92.11 ± 0.75%. The enzyme in the bioreactor was found to be stable for at least 6 days.
CONCLUSIONS: The lipase‐catalyzed synthesis of CAPE by an ultrasound‐assisted packed‐bed bioreactor uses mild reaction conditions. Enzymatic synthesis of CAPE is suitable for use in the nutraceutical and food production industries. Copyright © 2011 Society of Chemical Industry</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Bioreactors</subject><subject>Biotechnology</subject><subject>Catalysis</subject><subject>Catalytic reactions</subject><subject>Chemical engineering</subject><subject>Chemistry</subject><subject>Conversion</subject><subject>Esters</subject><subject>Ethyl alcohol</subject><subject>Exact sciences and technology</subject><subject>Flow rate</subject><subject>Food engineering</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General and physical chemistry</subject><subject>General aspects</subject><subject>lipase</subject><subject>Methods. Procedures. Technologies</subject><subject>Optimization</subject><subject>Others</subject><subject>packed-bed reactor</subject><subject>phenolic acid</subject><subject>Phenyls</subject><subject>Reactors</subject><subject>response surface methodology</subject><subject>Synthesis</subject><subject>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</subject><subject>ultrasonication</subject><subject>Various methods and equipments</subject><issn>0268-2575</issn><issn>1097-4660</issn><issn>1097-4660</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kM1q3DAURkVoIdM0i76BNoV2oUSS9WMvM0OatAwpgYQuxbUsMUoUeyrZtO7TR2aG7LoQV1zOd4Q-hD4xesEo5ZdPdmwvuFLsBK0YbTQRStF3aEW5qgmXWp6iDzk_UUpVzdUKzVfYDv0Y-mmYMp7imCAPU98RyDnk0XV4D_bZdaQt1zYMyYEdh4R9OePO4Rj2kB2xMEKc_xUmz33ZlywePLbgvQsWgw1FtHO9G3dzxK6I00f03kPM7vw4z9Djt-uHzS3Z_rz5vrnaEiuoZsS3LShWV5p3slO0oYJRIS1likvbCe84VFTWjolGdHWlQOqSoKKWBQBfVWfoy8G7T8PvqTxtXkK2LkboXfmzYZTpppQkeEG_HlCbhpyT82afwgukuUBmqdcs9Zql3sJ-PmohW4g-QW9DfgtwIQXlenFeHrg_Ibr5_0LzY_OwPprJIbH0__ctAenZKF1paX7d3Zh7cbe9Xzdrw6pXH2KZ-A</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Chen, Hsiao-Ching</creator><creator>Kuo, Chia-Hung</creator><creator>Twu, Yawo-Kuo</creator><creator>Chen, Jiann-Hwa</creator><creator>Chang, Chieh-Ming J.</creator><creator>Liu, Yung-Chuan</creator><creator>Shieh, Chwen-Jen</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>201110</creationdate><title>A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester</title><author>Chen, Hsiao-Ching ; Kuo, Chia-Hung ; Twu, Yawo-Kuo ; Chen, Jiann-Hwa ; Chang, Chieh-Ming J. ; Liu, Yung-Chuan ; Shieh, Chwen-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4071-fbba618372d5d609041045c01625cd4fe2a3058e1494d836a57bba0485625af33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Bioreactors</topic><topic>Biotechnology</topic><topic>Catalysis</topic><topic>Catalytic reactions</topic><topic>Chemical engineering</topic><topic>Chemistry</topic><topic>Conversion</topic><topic>Esters</topic><topic>Ethyl alcohol</topic><topic>Exact sciences and technology</topic><topic>Flow rate</topic><topic>Food engineering</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General and physical chemistry</topic><topic>General aspects</topic><topic>lipase</topic><topic>Methods. Procedures. Technologies</topic><topic>Optimization</topic><topic>Others</topic><topic>packed-bed reactor</topic><topic>phenolic acid</topic><topic>Phenyls</topic><topic>Reactors</topic><topic>response surface methodology</topic><topic>Synthesis</topic><topic>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</topic><topic>ultrasonication</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hsiao-Ching</creatorcontrib><creatorcontrib>Kuo, Chia-Hung</creatorcontrib><creatorcontrib>Twu, Yawo-Kuo</creatorcontrib><creatorcontrib>Chen, Jiann-Hwa</creatorcontrib><creatorcontrib>Chang, Chieh-Ming J.</creatorcontrib><creatorcontrib>Liu, Yung-Chuan</creatorcontrib><creatorcontrib>Shieh, Chwen-Jen</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of chemical technology and biotechnology (1986)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hsiao-Ching</au><au>Kuo, Chia-Hung</au><au>Twu, Yawo-Kuo</au><au>Chen, Jiann-Hwa</au><au>Chang, Chieh-Ming J.</au><au>Liu, Yung-Chuan</au><au>Shieh, Chwen-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester</atitle><jtitle>Journal of chemical technology and biotechnology (1986)</jtitle><addtitle>J. Chem. Technol. Biotechnol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>86</volume><issue>10</issue><spage>1289</spage><epage>1294</epage><pages>1289-1294</pages><issn>0268-2575</issn><issn>1097-4660</issn><eissn>1097-4660</eissn><coden>JCTBDC</coden><abstract>BACKGROUND: The focus of this paper is the ultrasound‐assisted synthesis of caffeic acid phenethyl ester (CAPE) from caffeic acid and phenyl ethanol in a continuous packed‐bed bioreactor. Immobilized Novozym® 435 (from Candida antarctica) is used as the catalyst. A three‐level–three‐factor Box–Behnken design and a response surface methodology (RSM) are employed to evaluate the effects of temperature, flow rate, and ultrasonic power on the percentage molar conversion of CAPE.
RESULTS: Based on ridge max analysis, it is concluded that the optimum condition for synthesis is reaction temperature 72.66 °C, flow rate 0.046 mL min−1, and ultrasonic power 1.64 W cm−2. The expected molar conversion value is 97.84%. An experiment performed under these optimal conditions resulted in a molar conversion of 92.11 ± 0.75%. The enzyme in the bioreactor was found to be stable for at least 6 days.
CONCLUSIONS: The lipase‐catalyzed synthesis of CAPE by an ultrasound‐assisted packed‐bed bioreactor uses mild reaction conditions. Enzymatic synthesis of CAPE is suitable for use in the nutraceutical and food production industries. Copyright © 2011 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jctb.2661</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of chemical technology and biotechnology (1986), 2011-10, Vol.86 (10), p.1289-1294 |
| issn | 0268-2575 1097-4660 1097-4660 |
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| subjects | Applied sciences Biological and medical sciences Bioreactors Biotechnology Catalysis Catalytic reactions Chemical engineering Chemistry Conversion Esters Ethyl alcohol Exact sciences and technology Flow rate Food engineering Food industries Fundamental and applied biological sciences. Psychology General and physical chemistry General aspects lipase Methods. Procedures. Technologies Optimization Others packed-bed reactor phenolic acid Phenyls Reactors response surface methodology Synthesis Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry ultrasonication Various methods and equipments |
| title | A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester |
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