Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer
The role of altered levels of insulin, leptin and adiponectin in contributing to the observed increased risk of colon cancer associated with obesity remains to be determined. Elevated insulin and leptin associated with obesity are linked to inflammatory responses. Conversely, adiponectin levels are...
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| Veröffentlicht in: | Molecular biology reports 2012-05, Vol.39 (5), p.5727-5736 |
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| creator | Farquharson, Andrew J. Steele, Robert J. Carey, Frank A. Drew, Janice E. |
| description | The role of altered levels of insulin, leptin and adiponectin in contributing to the observed increased risk of colon cancer associated with obesity remains to be determined. Elevated insulin and leptin associated with obesity are linked to inflammatory responses. Conversely, adiponectin levels are reduced in obese individuals and this hormone is generally associated with anti-inflammatory responses. Inflammatory cytokines are key components of processes linked with carcinogenesis. Insulin, leptin and adiponectin receptor expression profiles were assessed in human normal, adenomatous polyp and tumour tissue. Insulin, leptin and adiponectin regulation of inflammatory cytokines previously identified as being associated with early events in colon carcinogenesis were further investigated here using a surrogate colon epithelial cell line and a custom designed GeXP assay of the inflammatory cytokines (
CCL20
,
CXCL1
,
CXCL2
,
CXCL3
,
CXCL11
,
IL1RN
,
CXCL4
,
IL8
,
CCL19
,
CCL21
,
CCL23
,
CCL5
,
IL10RB
and
TNFRSF1A
). Mean insulin, leptin and adiponectin receptor expression levels were lower in adenomatous polyp samples in comparison with normal and tumour tissue. In contrast to leptin, insulin significantly reduced
CCL20
and CXCL11 and increased
CXCL3
expression. Full length adiponectin, but not globular adiponectin, induced
CCL5
,
CXCL1
,
CXCL3
and
CCL20
gene expression. GeXP assay permitted measurement of changes in gene expression of cytokines in response to insulin and adiponectin, indicating the potential for insulin and adiponectin regulation of mediators of inflammation associated with early events in colon carcinogenesis. |
| doi_str_mv | 10.1007/s11033-011-1382-1 |
| format | Article |
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CCL20
,
CXCL1
,
CXCL2
,
CXCL3
,
CXCL11
,
IL1RN
,
CXCL4
,
IL8
,
CCL19
,
CCL21
,
CCL23
,
CCL5
,
IL10RB
and
TNFRSF1A
). Mean insulin, leptin and adiponectin receptor expression levels were lower in adenomatous polyp samples in comparison with normal and tumour tissue. In contrast to leptin, insulin significantly reduced
CCL20
and CXCL11 and increased
CXCL3
expression. Full length adiponectin, but not globular adiponectin, induced
CCL5
,
CXCL1
,
CXCL3
and
CCL20
gene expression. GeXP assay permitted measurement of changes in gene expression of cytokines in response to insulin and adiponectin, indicating the potential for insulin and adiponectin regulation of mediators of inflammation associated with early events in colon carcinogenesis.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1382-1</identifier><identifier>PMID: 22193626</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adiponectin ; Adiponectin - genetics ; Adiponectin - metabolism ; Adiponectin - pharmacology ; Aged ; Aged, 80 and over ; Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Carcinogenesis ; CCL19 protein ; CCL20 protein ; CCL21 protein ; Cell Line, Tumor ; Colon - metabolism ; Colon - pathology ; Colon cancer ; Colonic Neoplasms - genetics ; Colonic Polyps - genetics ; Colonic Polyps - pathology ; Colorectal cancer ; CXCL11 protein ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; Epithelial cells ; Female ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation - drug effects ; Histology ; Hormones ; Humans ; Inflammation ; Inflammation Mediators - metabolism ; Insulin ; Insulin - genetics ; Insulin - metabolism ; Insulin - pharmacology ; Interleukin 1 ; Interleukin 8 ; Leptin ; Leptin - genetics ; Leptin - metabolism ; Leptin - pharmacology ; Life Sciences ; Male ; Middle Aged ; Molecular biology ; Morphology ; Multiplex Polymerase Chain Reaction - methods ; Obesity ; Polyps ; Real-Time Polymerase Chain Reaction ; Receptors, Adiponectin - genetics ; Receptors, Adiponectin - metabolism</subject><ispartof>Molecular biology reports, 2012-05, Vol.39 (5), p.5727-5736</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-b3b3cc90f9b53882e98285427e1bd6b454ad1000b538a8dc82f56e08e06f91a03</citedby><cites>FETCH-LOGICAL-c381t-b3b3cc90f9b53882e98285427e1bd6b454ad1000b538a8dc82f56e08e06f91a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1382-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1382-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22193626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farquharson, Andrew J.</creatorcontrib><creatorcontrib>Steele, Robert J.</creatorcontrib><creatorcontrib>Carey, Frank A.</creatorcontrib><creatorcontrib>Drew, Janice E.</creatorcontrib><title>Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>The role of altered levels of insulin, leptin and adiponectin in contributing to the observed increased risk of colon cancer associated with obesity remains to be determined. Elevated insulin and leptin associated with obesity are linked to inflammatory responses. Conversely, adiponectin levels are reduced in obese individuals and this hormone is generally associated with anti-inflammatory responses. Inflammatory cytokines are key components of processes linked with carcinogenesis. Insulin, leptin and adiponectin receptor expression profiles were assessed in human normal, adenomatous polyp and tumour tissue. Insulin, leptin and adiponectin regulation of inflammatory cytokines previously identified as being associated with early events in colon carcinogenesis were further investigated here using a surrogate colon epithelial cell line and a custom designed GeXP assay of the inflammatory cytokines (
CCL20
,
CXCL1
,
CXCL2
,
CXCL3
,
CXCL11
,
IL1RN
,
CXCL4
,
IL8
,
CCL19
,
CCL21
,
CCL23
,
CCL5
,
IL10RB
and
TNFRSF1A
). Mean insulin, leptin and adiponectin receptor expression levels were lower in adenomatous polyp samples in comparison with normal and tumour tissue. In contrast to leptin, insulin significantly reduced
CCL20
and CXCL11 and increased
CXCL3
expression. Full length adiponectin, but not globular adiponectin, induced
CCL5
,
CXCL1
,
CXCL3
and
CCL20
gene expression. GeXP assay permitted measurement of changes in gene expression of cytokines in response to insulin and adiponectin, indicating the potential for insulin and adiponectin regulation of mediators of inflammation associated with early events in colon carcinogenesis.</description><subject>Adiponectin</subject><subject>Adiponectin - genetics</subject><subject>Adiponectin - metabolism</subject><subject>Adiponectin - pharmacology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Carcinogenesis</subject><subject>CCL19 protein</subject><subject>CCL20 protein</subject><subject>CCL21 protein</subject><subject>Cell Line, Tumor</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Polyps - genetics</subject><subject>Colonic Polyps - pathology</subject><subject>Colorectal cancer</subject><subject>CXCL11 protein</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Epithelial cells</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Histology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Insulin</subject><subject>Insulin - genetics</subject><subject>Insulin - metabolism</subject><subject>Insulin - pharmacology</subject><subject>Interleukin 1</subject><subject>Interleukin 8</subject><subject>Leptin</subject><subject>Leptin - genetics</subject><subject>Leptin - metabolism</subject><subject>Leptin - pharmacology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>Multiplex Polymerase Chain Reaction - methods</subject><subject>Obesity</subject><subject>Polyps</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptors, Adiponectin - genetics</subject><subject>Receptors, Adiponectin - metabolism</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcFu1DAQhi0EotuFB-CCLE4cSPHYceIcUQUUqSoXOEeOM2ldHDvYDrDXPnkdbQEJiYstaz5_M5qfkBfAzoCx9m0CYEJUDKACoXgFj8gOZCuqumvVY7JjgkFVKwkn5DSlW8ZYDa18Sk44h040vNmRu6vwAx2dV5ft4vAXnTHfhJHmQHVKmBK1Pq3O-jfU4ZKtp9qPVI92CR7N9o54vTqdbfA0TIWenJ5nnUM8UHPI4Zv1mDZXMFZnHOlPm2-oCa7wRnuD8Rl5MmmX8PnDvSdfP7z_cn5RXX7--On83WVlhIJcDWIQxnRs6gYplOLYKa5kzVuEYWyGWtZ6LFthW1Wr0Sg-yQaZQtZMHWgm9uT10bvE8H3FlPvZJoPOaY9hTT0waLtGlv0V9NU_6G1Yoy_T9Z2oJZcd33xwhEwMKUWc-iXaWcdDMfVbPv0xn77k02_5lGNPXj6I12HG8c-P34EUgB-BVEr-GuPfzv-33gNbLpyw</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Farquharson, Andrew J.</creator><creator>Steele, Robert J.</creator><creator>Carey, Frank A.</creator><creator>Drew, Janice E.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20120501</creationdate><title>Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer</title><author>Farquharson, Andrew J. ; Steele, Robert J. ; Carey, Frank A. ; Drew, Janice E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-b3b3cc90f9b53882e98285427e1bd6b454ad1000b538a8dc82f56e08e06f91a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adiponectin</topic><topic>Adiponectin - genetics</topic><topic>Adiponectin - metabolism</topic><topic>Adiponectin - pharmacology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Carcinogenesis</topic><topic>CCL19 protein</topic><topic>CCL20 protein</topic><topic>CCL21 protein</topic><topic>Cell Line, Tumor</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Polyps - genetics</topic><topic>Colonic Polyps - pathology</topic><topic>Colorectal cancer</topic><topic>CXCL11 protein</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Epithelial cells</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Histology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Insulin</topic><topic>Insulin - genetics</topic><topic>Insulin - metabolism</topic><topic>Insulin - pharmacology</topic><topic>Interleukin 1</topic><topic>Interleukin 8</topic><topic>Leptin</topic><topic>Leptin - genetics</topic><topic>Leptin - metabolism</topic><topic>Leptin - pharmacology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>Multiplex Polymerase Chain Reaction - methods</topic><topic>Obesity</topic><topic>Polyps</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptors, Adiponectin - genetics</topic><topic>Receptors, Adiponectin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farquharson, Andrew J.</creatorcontrib><creatorcontrib>Steele, Robert J.</creatorcontrib><creatorcontrib>Carey, Frank A.</creatorcontrib><creatorcontrib>Drew, Janice E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farquharson, Andrew J.</au><au>Steele, Robert J.</au><au>Carey, Frank A.</au><au>Drew, Janice E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>39</volume><issue>5</issue><spage>5727</spage><epage>5736</epage><pages>5727-5736</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>The role of altered levels of insulin, leptin and adiponectin in contributing to the observed increased risk of colon cancer associated with obesity remains to be determined. Elevated insulin and leptin associated with obesity are linked to inflammatory responses. Conversely, adiponectin levels are reduced in obese individuals and this hormone is generally associated with anti-inflammatory responses. Inflammatory cytokines are key components of processes linked with carcinogenesis. Insulin, leptin and adiponectin receptor expression profiles were assessed in human normal, adenomatous polyp and tumour tissue. Insulin, leptin and adiponectin regulation of inflammatory cytokines previously identified as being associated with early events in colon carcinogenesis were further investigated here using a surrogate colon epithelial cell line and a custom designed GeXP assay of the inflammatory cytokines (
CCL20
,
CXCL1
,
CXCL2
,
CXCL3
,
CXCL11
,
IL1RN
,
CXCL4
,
IL8
,
CCL19
,
CCL21
,
CCL23
,
CCL5
,
IL10RB
and
TNFRSF1A
). Mean insulin, leptin and adiponectin receptor expression levels were lower in adenomatous polyp samples in comparison with normal and tumour tissue. In contrast to leptin, insulin significantly reduced
CCL20
and CXCL11 and increased
CXCL3
expression. Full length adiponectin, but not globular adiponectin, induced
CCL5
,
CXCL1
,
CXCL3
and
CCL20
gene expression. GeXP assay permitted measurement of changes in gene expression of cytokines in response to insulin and adiponectin, indicating the potential for insulin and adiponectin regulation of mediators of inflammation associated with early events in colon carcinogenesis.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22193626</pmid><doi>10.1007/s11033-011-1382-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular biology reports, 2012-05, Vol.39 (5), p.5727-5736 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adiponectin Adiponectin - genetics Adiponectin - metabolism Adiponectin - pharmacology Aged Aged, 80 and over Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Carcinogenesis CCL19 protein CCL20 protein CCL21 protein Cell Line, Tumor Colon - metabolism Colon - pathology Colon cancer Colonic Neoplasms - genetics Colonic Polyps - genetics Colonic Polyps - pathology Colorectal cancer CXCL11 protein Cytokines Cytokines - genetics Cytokines - metabolism Epithelial cells Female Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Histology Hormones Humans Inflammation Inflammation Mediators - metabolism Insulin Insulin - genetics Insulin - metabolism Insulin - pharmacology Interleukin 1 Interleukin 8 Leptin Leptin - genetics Leptin - metabolism Leptin - pharmacology Life Sciences Male Middle Aged Molecular biology Morphology Multiplex Polymerase Chain Reaction - methods Obesity Polyps Real-Time Polymerase Chain Reaction Receptors, Adiponectin - genetics Receptors, Adiponectin - metabolism |
| title | Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer |
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