Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt's lymphoma cells

Bryonia dioica Jacq. is a climbing perennial herb with tuberous roots which is widely used in traditional medicine in Algeria for the treatment of cancers; it belongs to the genus Bryonia (Cucurbitaceae). To investigate the cytotoxic and apoptogenic activities, the phytochemical composition and acut...

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Veröffentlicht in:	Journal of ethnopharmacology 2012-05, Vol.141 (1), p.510-516
Hauptverfasser:	Benarba, Bachir, Meddah, Boumedienne, Aoues, Abdelkader
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Alkaloids Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity Apoptosis Apoptosis - drug effects Blotting, Western Bryonia Bryonia - chemistry Bryonia cretica Bryonia dioica Burkitt Lymphoma - metabolism Burkitt Lymphoma - pathology Burkitt's lymphoma Burkitt's lymphoma BL41 cell lines Cancer Carbohydrates Caspase Caspase 3 - metabolism Caspase 9 - metabolism Caspase-3 Cell Line, Tumor Climbing Cucurbitaceae Cytotoxicity DNA Dose-Response Relationship, Drug Flavonoids Flow Cytometry fluorescent dyes Fluorescent indicators Herbs Humans Inhibitory Concentration 50 iodides Light Light scattering lymphoma Membrane potential Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial pathway Phytochemicals Phytotherapy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - toxicity Plant Roots Plants, Medicinal Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism Polyphenols propidium iodide Roots Saponins Scattering, Radiation screening Signal Transduction - drug effects Solvents - chemistry Sterols therapeutics traditional medicine triterpenes triterpenoids Tumor cell lines Water - chemistry Western blotting
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