Standard of care therapy for malignant glioma and its effect on tumor and stromal cells
Glioblastoma is the most common and deadly of the primary central nervous system tumors. Recent advances in molecular characterization have subdivided these tumors into at least three main groups. In addition, these tumors are cellularly complex with multiple stromal cell types contributing to the b...
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| Veröffentlicht in: | Oncogene 2012-04, Vol.31 (16), p.1995-2006 |
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| creator | Jones, T S Holland, E C |
| description | Glioblastoma is the most common and deadly of the primary central nervous system tumors. Recent advances in molecular characterization have subdivided these tumors into at least three main groups. In addition, these tumors are cellularly complex with multiple stromal cell types contributing to the biology of the tumor and treatment response. Because essentially all glioma patients are treated with radiation, various chemotherapies and steroids, the tumor that finally kills them has been modified by these treatments. Most of the investigation of the effects of therapy on these tumors has focused on the glioma cells
per se
. However, despite the importance of the stromal cells in these tumors, little has been done to understand the effects of treatment on stromal cells and their contribution to disease. Understanding how current standard therapy affects the biology of the tumor and the tumor stroma may provide insight into the mechanisms that are important to the inhibition of tumor growth as well as the biology of recurrent tumors. |
| doi_str_mv | 10.1038/onc.2011.398 |
| format | Article |
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per se
. However, despite the importance of the stromal cells in these tumors, little has been done to understand the effects of treatment on stromal cells and their contribution to disease. Understanding how current standard therapy affects the biology of the tumor and the tumor stroma may provide insight into the mechanisms that are important to the inhibition of tumor growth as well as the biology of recurrent tumors.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2011.398</identifier><identifier>PMID: 21909136</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Apoptosis ; Biology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - therapy ; Brain tumors ; Cell Biology ; Cells ; Central nervous system ; Chemotherapy ; Development and progression ; Drug therapy ; Glioblastoma ; Glioma ; Glioma - drug therapy ; Glioma - pathology ; Glioma - radiotherapy ; Glioma - therapy ; Glioma cells ; Gliomas ; Human Genetics ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; review ; Standard of Care ; Steroid hormones ; Steroids ; Stromal cells ; Stromal Cells - drug effects ; Stromal Cells - pathology ; Stromal Cells - radiation effects ; Therapy ; Tumors</subject><ispartof>Oncogene, 2012-04, Vol.31 (16), p.1995-2006</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 19, 2012</rights><rights>Macmillan Publishers Limited 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-4e30d9963a32ff285acbafd11a3effc556176f531b42c802eb1a4141fa261d643</citedby><cites>FETCH-LOGICAL-c550t-4e30d9963a32ff285acbafd11a3effc556176f531b42c802eb1a4141fa261d643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/onc.2011.398$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/onc.2011.398$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21909136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, T S</creatorcontrib><creatorcontrib>Holland, E C</creatorcontrib><title>Standard of care therapy for malignant glioma and its effect on tumor and stromal cells</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Glioblastoma is the most common and deadly of the primary central nervous system tumors. Recent advances in molecular characterization have subdivided these tumors into at least three main groups. In addition, these tumors are cellularly complex with multiple stromal cell types contributing to the biology of the tumor and treatment response. Because essentially all glioma patients are treated with radiation, various chemotherapies and steroids, the tumor that finally kills them has been modified by these treatments. Most of the investigation of the effects of therapy on these tumors has focused on the glioma cells
per se
. However, despite the importance of the stromal cells in these tumors, little has been done to understand the effects of treatment on stromal cells and their contribution to disease. Understanding how current standard therapy affects the biology of the tumor and the tumor stroma may provide insight into the mechanisms that are important to the inhibition of tumor growth as well as the biology of recurrent tumors.</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Biology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - therapy</subject><subject>Brain tumors</subject><subject>Cell Biology</subject><subject>Cells</subject><subject>Central nervous system</subject><subject>Chemotherapy</subject><subject>Development and progression</subject><subject>Drug therapy</subject><subject>Glioblastoma</subject><subject>Glioma</subject><subject>Glioma - drug therapy</subject><subject>Glioma - pathology</subject><subject>Glioma - radiotherapy</subject><subject>Glioma - therapy</subject><subject>Glioma cells</subject><subject>Gliomas</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>review</subject><subject>Standard of Care</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Stromal cells</subject><subject>Stromal Cells - drug effects</subject><subject>Stromal Cells - pathology</subject><subject>Stromal Cells - radiation effects</subject><subject>Therapy</subject><subject>Tumors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0ctrFTEUBvAgFntb3bmWgBsXnWtOXjNZluILCl204jKcm0muU2Ym1ySz6H9vhlsfiIirQPLjOyd8hLwEtgUmurdxdlvOALbCdE_IBmSrG6WMfEo2zCjWGC74KTnL-Z4x1hrGn5FTDoYZEHpDvtwWnHtMPY2BOkyelq8-4eGBhpjohOOwn3EudD8OcUJaLR1Kpj4E7wqNMy3LVOF6n0uqZKTOj2N-Tk4Cjtm_eDzPyef37-6uPjbXNx8-XV1eN04pVhrpBeuN0QIFD4F3Ct0OQw-Aoo6oRkOrgxKwk9x1jPsdoAQJAbmGXktxTt4ccw8pflt8LnYa8roBzj4u2QKD1iijpP4PyrqOK6XaSl__Qe_jkub6Ecu1BFVDufmXqllccyaU_KX2OHo7zCGWhG4dbS9510lupFwnXhyVSzHn5IM9pGHC9FCj7NqzrT3btWdbe6781ePoZTf5_if-UWwFzRHk-jTvffp9t78Efgdzm66D</recordid><startdate>20120419</startdate><enddate>20120419</enddate><creator>Jones, T S</creator><creator>Holland, E C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20120419</creationdate><title>Standard of care therapy for malignant glioma and its effect on tumor and stromal cells</title><author>Jones, T S ; Holland, E C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-4e30d9963a32ff285acbafd11a3effc556176f531b42c802eb1a4141fa261d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Apoptosis</topic><topic>Biology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - therapy</topic><topic>Brain tumors</topic><topic>Cell Biology</topic><topic>Cells</topic><topic>Central nervous system</topic><topic>Chemotherapy</topic><topic>Development and progression</topic><topic>Drug therapy</topic><topic>Glioblastoma</topic><topic>Glioma</topic><topic>Glioma - drug therapy</topic><topic>Glioma - pathology</topic><topic>Glioma - radiotherapy</topic><topic>Glioma - therapy</topic><topic>Glioma cells</topic><topic>Gliomas</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>review</topic><topic>Standard of Care</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Stromal cells</topic><topic>Stromal Cells - drug effects</topic><topic>Stromal Cells - pathology</topic><topic>Stromal Cells - radiation effects</topic><topic>Therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, T S</creatorcontrib><creatorcontrib>Holland, E C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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per se
. However, despite the importance of the stromal cells in these tumors, little has been done to understand the effects of treatment on stromal cells and their contribution to disease. Understanding how current standard therapy affects the biology of the tumor and the tumor stroma may provide insight into the mechanisms that are important to the inhibition of tumor growth as well as the biology of recurrent tumors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21909136</pmid><doi>10.1038/onc.2011.398</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antimitotic agents Antineoplastic agents Apoptosis Biology Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain Neoplasms - therapy Brain tumors Cell Biology Cells Central nervous system Chemotherapy Development and progression Drug therapy Glioblastoma Glioma Glioma - drug therapy Glioma - pathology Glioma - radiotherapy Glioma - therapy Glioma cells Gliomas Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Oncology review Standard of Care Steroid hormones Steroids Stromal cells Stromal Cells - drug effects Stromal Cells - pathology Stromal Cells - radiation effects Therapy Tumors |
| title | Standard of care therapy for malignant glioma and its effect on tumor and stromal cells |
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