Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNases

T-cell-derived soluble factors that inhibit both X4 and R5 HIV are recognized as important in controlling HIV. Whereas three β chemokines, regulated-on-activation normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1α, and MIP-1β, account for the suppression of R5 HI...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (14), p.5411-5416
Hauptverfasser:	Cocchi, Fiorenza, DeVico, Anthony L, Lu, Wuyuan, Popovic, Mikulas, Latinovic, Olga, Sajadi, Mohammad M, Redfield, Robert R, Lafferty, Mark K, Galli, Massimo, Garzino-Demo, Alfredo, Gallo, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Angiogenin Anti-HIV Agents Anti-HIV Agents - pharmacology Antivirals Biological Sciences CC chemokines CCL17 protein CD4 antigen CD8 antigen CD8-positive T-lymphocytes Chemokines Chemokines, CC Chemokines, CC - metabolism Dose-Response Relationship, Drug drug effects HIV HIV - metabolism HIV - physiology HIV 1 HIV infections Human immunodeficiency virus Humans Infections Ligands Lymphocytes T Macrophage inflammatory protein Macrophage-derived chemokine metabolism pharmacology physiology RANTES ribonucleases Ribonucleases - metabolism Solubility T lymphocytes T-Lymphocytes - metabolism Thymus Virus Replication Virus Replication - drug effects Viruses
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