The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes
Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best...
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| Veröffentlicht in: | Toxicology and industrial health 2012-05, Vol.28 (4), p.327-333 |
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| creator | Togar, Başak Turkez, Hasan Tatar, Abdulgani Kırkpınar, Ismet Hacımuftuoglu, Ahmet Geyikoglu, Fatime Keles, M Sait Dirican, Ebubekir |
| description | Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0–400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed. |
| doi_str_mv | 10.1177/0748233711410919 |
| format | Article |
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However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0–400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233711410919</identifier><identifier>PMID: 21937534</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Analysis of Variance ; Antipsychotic Agents - toxicity ; Antipsychotics ; Benzodiazepines - toxicity ; Blood & organ donations ; Cell Survival - drug effects ; Dibenzothiazepines - toxicity ; DNA Damage ; Drug dosages ; Hematology ; Humans ; Lymphocytes ; Lymphocytes - drug effects ; Micronucleus Tests ; Mutagenicity Tests ; Mutagens - toxicity ; Psychotropic drugs ; Quetiapine Fumarate ; Risperidone - toxicity ; Schizophrenia ; Toxicology ; Tumors</subject><ispartof>Toxicology and industrial health, 2012-05, Vol.28 (4), p.327-333</ispartof><rights>The Author(s) 2011</rights><rights>SAGE Publications © May 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-85d9c339bc7a3b41d493f2cd04b3a33647d5991eb4c5f66374d43e1eea5027783</citedby><cites>FETCH-LOGICAL-c397t-85d9c339bc7a3b41d493f2cd04b3a33647d5991eb4c5f66374d43e1eea5027783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233711410919$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233711410919$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21937534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Togar, Başak</creatorcontrib><creatorcontrib>Turkez, Hasan</creatorcontrib><creatorcontrib>Tatar, Abdulgani</creatorcontrib><creatorcontrib>Kırkpınar, Ismet</creatorcontrib><creatorcontrib>Hacımuftuoglu, Ahmet</creatorcontrib><creatorcontrib>Geyikoglu, Fatime</creatorcontrib><creatorcontrib>Keles, M Sait</creatorcontrib><creatorcontrib>Dirican, Ebubekir</creatorcontrib><title>The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0–400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.</description><subject>Analysis of Variance</subject><subject>Antipsychotic Agents - toxicity</subject><subject>Antipsychotics</subject><subject>Benzodiazepines - toxicity</subject><subject>Blood & organ donations</subject><subject>Cell Survival - drug effects</subject><subject>Dibenzothiazepines - toxicity</subject><subject>DNA Damage</subject><subject>Drug dosages</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Micronucleus Tests</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Psychotropic drugs</subject><subject>Quetiapine Fumarate</subject><subject>Risperidone - 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genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2012-05</date><risdate>2012</risdate><volume>28</volume><issue>4</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0–400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21937534</pmid><doi>10.1177/0748233711410919</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Antipsychotic Agents - toxicity Antipsychotics Benzodiazepines - toxicity Blood & organ donations Cell Survival - drug effects Dibenzothiazepines - toxicity DNA Damage Drug dosages Hematology Humans Lymphocytes Lymphocytes - drug effects Micronucleus Tests Mutagenicity Tests Mutagens - toxicity Psychotropic drugs Quetiapine Fumarate Risperidone - toxicity Schizophrenia Toxicology Tumors |
| title | The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes |
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