Targeting dendritic cells with antigen via dendritic cell-associated promoters

The induction of tumor-specific immune responses is largely dependent on the ability of dendritic cells (DCs) to present tumor-associated antigens to T lymphocytes. Therefore, we investigated the use of DC-associated promoter-driven genetic vaccines to specifically target DC in vivo . Restricted exp...

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Veröffentlicht in:	Cancer gene therapy 2012-05, Vol.19 (5), p.303-311
Hauptverfasser:	Moulin, V, Morgan, M E, Eleveld-Trancikova, D, Haanen, J B A G, Wielders, E, Looman, M W G, Janssen, R A J, Figdor, C G, Jansen, B J H, Adema, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/133 631/61/51/201 Animal models Animals Antigen (tumor-associated) Antigen Presentation Antigens Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Biomedical and Life Sciences Biomedicine CD11c antigen CD11c Antigen - genetics CD11c Antigen - immunology CD4 antigen CD8 antigen Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell proliferation DC-SIGN protein DC-STAMP protein Dendritic cells Dendritic Cells - immunology Electroporation Female Gene Expression Gene Therapy Green fluorescent protein Immune response Immunotherapy, Adoptive - methods Lectins, C-Type - genetics Lectins, C-Type - immunology Lymphocytes T Melanoma, Experimental - immunology Melanoma, Experimental - therapy Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology NIH 3T3 Cells original-article Ovalbumin Physiological aspects Promoter Regions, Genetic Promoters Promoters (Genetics) Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology T-Lymphocytes - immunology Transfection Vaccines Vaccines, DNA - genetics Vaccines, DNA - immunology
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