Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: Unusually high frequency of down-regulation in breast cancer tissues

A novel monoclonal anti‐pan human leukocyte antigen (HLA) class I heavy chain antibody, EMR8‐5, was established. It could detect HLA‐A, ‐B, and ‐C antigens in formalin‐fixed paraffin embedded tissues. By immunohistochemical staining using the EMR8‐5 antibody, various cancer tissues from 246 cases we...

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Veröffentlicht in:	Pathology international 2012-05, Vol.62 (5), p.303-308
Hauptverfasser:	Torigoe, Toshihiko, Asanuma, Hiroko, Nakazawa, Emiri, Tamura, Yasuaki, Hirohashi, Yoshihiko, Yamamoto, Eri, Kanaseki, Takayuki, Hasegawa, Tadashi, Sato, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - immunology antigen presentation Antigens, Neoplasm - immunology beta 2-microglobulin beta 2-Microglobulin - metabolism beta2-microglobulin Biomarkers, Tumor Breast cancer Breast Neoplasms - immunology Breast Neoplasms - pathology Colon cancer Down-Regulation Female Formaldehyde Genes, MHC Class I - immunology Hepatocellular carcinoma Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Humans Immune escape Immunohistochemistry - methods Lung cancer MHC class I Paraffin renal cell carcinoma Tissue Fixation urothelial carcinoma
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