Response of Osteoclasts to Titanium Surfaces with Increasing Surface Roughness: An In Vitro Study
Osteoclasts are responsible for bone resorption and implant surface roughness promotes osseointegration. However, little is known about the effect of roughness on osteoclast activity. This study aims at the characterization of osteoclastic response to surface roughness. The number of osteoclasts, th...
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| Veröffentlicht in: | Biointerphases 2012-12, Vol.7 (1-4), p.34-34 |
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| creator | Brinkmann, Jenny Hefti, Thomas Schlottig, Falko Spencer, Nicholas D. Hall, Heike |
| description | Osteoclasts are responsible for bone resorption and implant surface roughness promotes osseointegration. However, little is known about the effect of roughness on osteoclast activity. This study aims at the characterization of osteoclastic response to surface roughness. The number of osteoclasts, the tartrate-resistant acid phosphatase and matrix metalloproteinase (MMP) activities, the cell morphology and the actin-ring formation were examined on smooth (TS), acid-etched (TA) and sandblasted acid-etched (TLA) titanium and on native bone. Cell morphology was comparable on TA, TLA and bone, actin rings being similar in size on TLA and bone, but smaller on TA and virtually absent on TS. Gelatin zymography revealed increased proMMP-9 expression on TA, TLA, and bone compared to TS. In general, osteoclasts show similar characteristics on rough titanium surfaces and on bone, but reduced activity on smooth titanium surfaces. These results offer some insight into the involvement of osteoclasts in remodeling processes around implant surfaces. |
| doi_str_mv | 10.1007/s13758-012-0034-x |
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However, little is known about the effect of roughness on osteoclast activity. This study aims at the characterization of osteoclastic response to surface roughness. The number of osteoclasts, the tartrate-resistant acid phosphatase and matrix metalloproteinase (MMP) activities, the cell morphology and the actin-ring formation were examined on smooth (TS), acid-etched (TA) and sandblasted acid-etched (TLA) titanium and on native bone. Cell morphology was comparable on TA, TLA and bone, actin rings being similar in size on TLA and bone, but smaller on TA and virtually absent on TS. Gelatin zymography revealed increased proMMP-9 expression on TA, TLA, and bone compared to TS. In general, osteoclasts show similar characteristics on rough titanium surfaces and on bone, but reduced activity on smooth titanium surfaces. 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However, little is known about the effect of roughness on osteoclast activity. This study aims at the characterization of osteoclastic response to surface roughness. The number of osteoclasts, the tartrate-resistant acid phosphatase and matrix metalloproteinase (MMP) activities, the cell morphology and the actin-ring formation were examined on smooth (TS), acid-etched (TA) and sandblasted acid-etched (TLA) titanium and on native bone. Cell morphology was comparable on TA, TLA and bone, actin rings being similar in size on TLA and bone, but smaller on TA and virtually absent on TS. Gelatin zymography revealed increased proMMP-9 expression on TA, TLA, and bone compared to TS. In general, osteoclasts show similar characteristics on rough titanium surfaces and on bone, but reduced activity on smooth titanium surfaces. These results offer some insight into the involvement of osteoclasts in remodeling processes around implant surfaces.</description><subject>Acid Phosphatase - metabolism</subject><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biophysics</subject><subject>Cattle</subject><subject>Cell Adhesion</subject><subject>Cell Shape</subject><subject>Chemistry and Materials Science</subject><subject>Isoenzymes - metabolism</subject><subject>Materials Science</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Mice</subject><subject>Osteoclasts - cytology</subject><subject>Osteoclasts - enzymology</subject><subject>Osteoclasts - physiology</subject><subject>Physical Chemistry</subject><subject>Surface and Interface Science</subject><subject>Surface Properties</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><subject>Thin Films</subject><subject>Titanium - chemistry</subject><issn>1934-8630</issn><issn>1559-4106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMo7g_gRXL00pql0-n2JuIGguB2DemkemyZScZUGvXtjYx69FRF1Vc_1EfIAWfHnDF9glxq1VaMi4oxWVcfa2SbK9VVNWfNeum7MmwbybbIDuIrY7VSjdwkW0I0smOd3Cb2HnAZAwKNA73DDNHNLWakOdLHMdswTgv6MKXBOkD6PuYXehNcAotjmP0u6H2cZi8BEE_pWSgAfR5zivQhT_5zj2wMdo6w_1N3ydPlxeP5dXV7d3VzfnZbuVqwXMmukbxXTQNu4BKUkKCl5b5tvRc9s0IPfc-FH1qvtGpaDbXyrgXvVK97p-QuOVrlLlN8mwCzWYzoYD63AeKEhjOudXEhdEH5CnUpIiYYzDKNC5s-C2S-zZqVWVPMmm-z5qPcHP7ET_0C_N_Fr8oCiBWAZRVmkMxrnFIoL_-T-gVo_YUa</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Brinkmann, Jenny</creator><creator>Hefti, Thomas</creator><creator>Schlottig, Falko</creator><creator>Spencer, Nicholas D.</creator><creator>Hall, Heike</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Response of Osteoclasts to Titanium Surfaces with Increasing Surface Roughness: An In Vitro Study</title><author>Brinkmann, Jenny ; Hefti, Thomas ; Schlottig, Falko ; Spencer, Nicholas D. ; Hall, Heike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-39631b566ecf13e523e73a1d88dd2b0a27fbb12df8d575687e45dc8edc5b7bc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acid Phosphatase - metabolism</topic><topic>Actins - metabolism</topic><topic>Animals</topic><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biophysics</topic><topic>Cattle</topic><topic>Cell Adhesion</topic><topic>Cell Shape</topic><topic>Chemistry and Materials Science</topic><topic>Isoenzymes - metabolism</topic><topic>Materials Science</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Mice</topic><topic>Osteoclasts - cytology</topic><topic>Osteoclasts - enzymology</topic><topic>Osteoclasts - physiology</topic><topic>Physical Chemistry</topic><topic>Surface and Interface Science</topic><topic>Surface Properties</topic><topic>Tartrate-Resistant Acid Phosphatase</topic><topic>Thin Films</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brinkmann, Jenny</creatorcontrib><creatorcontrib>Hefti, Thomas</creatorcontrib><creatorcontrib>Schlottig, Falko</creatorcontrib><creatorcontrib>Spencer, Nicholas D.</creatorcontrib><creatorcontrib>Hall, Heike</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biointerphases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brinkmann, Jenny</au><au>Hefti, Thomas</au><au>Schlottig, Falko</au><au>Spencer, Nicholas D.</au><au>Hall, Heike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of Osteoclasts to Titanium Surfaces with Increasing Surface Roughness: An In Vitro Study</atitle><jtitle>Biointerphases</jtitle><stitle>Biointerphases</stitle><addtitle>Biointerphases</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>7</volume><issue>1-4</issue><spage>34</spage><epage>34</epage><pages>34-34</pages><issn>1934-8630</issn><eissn>1559-4106</eissn><abstract>Osteoclasts are responsible for bone resorption and implant surface roughness promotes osseointegration. However, little is known about the effect of roughness on osteoclast activity. This study aims at the characterization of osteoclastic response to surface roughness. The number of osteoclasts, the tartrate-resistant acid phosphatase and matrix metalloproteinase (MMP) activities, the cell morphology and the actin-ring formation were examined on smooth (TS), acid-etched (TA) and sandblasted acid-etched (TLA) titanium and on native bone. Cell morphology was comparable on TA, TLA and bone, actin rings being similar in size on TLA and bone, but smaller on TA and virtually absent on TS. Gelatin zymography revealed increased proMMP-9 expression on TA, TLA, and bone compared to TS. In general, osteoclasts show similar characteristics on rough titanium surfaces and on bone, but reduced activity on smooth titanium surfaces. 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| subjects | Acid Phosphatase - metabolism Actins - metabolism Animals Biological and Medical Physics Biomaterials Biomedical Engineering and Bioengineering Biophysics Cattle Cell Adhesion Cell Shape Chemistry and Materials Science Isoenzymes - metabolism Materials Science Matrix Metalloproteinases - metabolism Mice Osteoclasts - cytology Osteoclasts - enzymology Osteoclasts - physiology Physical Chemistry Surface and Interface Science Surface Properties Tartrate-Resistant Acid Phosphatase Thin Films Titanium - chemistry |
| title | Response of Osteoclasts to Titanium Surfaces with Increasing Surface Roughness: An In Vitro Study |
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