Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA

Translation arrest leads to an endonucleolytic cleavage of mRNA that is termed no-go decay (NGD). It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and dissociates subunits of a stalled ribosome in vitro. Here we r...

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Veröffentlicht in:	Molecular cell 2012-05, Vol.46 (4), p.518-529
Hauptverfasser:	Tsuboi, Tatsuhisa, Kuroha, Kazushige, Kudo, Kazuhei, Makino, Shiho, Inoue, Eri, Kashima, Isao, Inada, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Base Sequence Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism dissociation Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism exosomes GTP-Binding Proteins - chemistry GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HSP70 Heat-Shock Proteins - chemistry HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism messenger RNA Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nonsense Mediated mRNA Decay Peptide Chain Elongation, Translational Peptide Elongation Factors - chemistry Peptide Elongation Factors - genetics Peptide Elongation Factors - metabolism Protein Interaction Domains and Motifs quality control ribosomes Ribosomes - metabolism RNA Stability RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism stalls translation (genetics)
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