Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA
Translation arrest leads to an endonucleolytic cleavage of mRNA that is termed no-go decay (NGD). It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and dissociates subunits of a stalled ribosome in vitro. Here we r...
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| Veröffentlicht in: | Molecular cell 2012-05, Vol.46 (4), p.518-529 |
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| creator | Tsuboi, Tatsuhisa Kuroha, Kazushige Kudo, Kazuhei Makino, Shiho Inoue, Eri Kashima, Isao Inada, Toshifumi |
| description | Translation arrest leads to an endonucleolytic cleavage of mRNA that is termed no-go decay (NGD). It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and dissociates subunits of a stalled ribosome in vitro. Here we report that Dom34:Hbs1 dissociates the subunits of a ribosome that is stalled at the 3′ end of mRNA in vivo, and has a crucial role in both NGD and nonstop decay. Dom34:Hbs1-mediated dissociation of a ribosome that is stalled at the 3′ end of mRNA is required for degradation of a 5′-NGD intermediate. Dom34:Hbs1 facilitates the decay of nonstop mRNAs from the 3′ end by exosomes and is required for the complete degradation of nonstop mRNA decay intermediates. We propose that Dom34:Hbs1 stimulates degradation of the 5′-NGD intermediate and of nonstop mRNA by dissociating the ribosome that is stalled at the 3′ end of the mRNA.
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► Dom34:Hbs1 dissociates subunits of ribosome stalled at the 3′ end of mRNA in vivo ► Dom34:Hbs1 facilitates the decay of nonstop mRNA and 5′-NGD intermediate by exosome ► Ribosomes stalled at the 3′ end of mRNA induce sequential endonucleolytic cleavages ► Carboxy-terminal region of Ski7 and Dom34:Hbs1 play independent roles in NSD |
| doi_str_mv | 10.1016/j.molcel.2012.03.013 |
| format | Article |
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[Display omitted]
► Dom34:Hbs1 dissociates subunits of ribosome stalled at the 3′ end of mRNA in vivo ► Dom34:Hbs1 facilitates the decay of nonstop mRNA and 5′-NGD intermediate by exosome ► Ribosomes stalled at the 3′ end of mRNA induce sequential endonucleolytic cleavages ► Carboxy-terminal region of Ski7 and Dom34:Hbs1 play independent roles in NSD</description><identifier>ISSN: 1097-2765</identifier><identifier>EISSN: 1097-4164</identifier><identifier>DOI: 10.1016/j.molcel.2012.03.013</identifier><identifier>PMID: 22503425</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptor Proteins, Signal Transducing - chemistry ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Base Sequence ; Cell Cycle Proteins - chemistry ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; dissociation ; Endoribonucleases - chemistry ; Endoribonucleases - genetics ; Endoribonucleases - metabolism ; exosomes ; GTP-Binding Proteins - chemistry ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; HSP70 Heat-Shock Proteins - chemistry ; HSP70 Heat-Shock Proteins - genetics ; HSP70 Heat-Shock Proteins - metabolism ; messenger RNA ; Multiprotein Complexes - chemistry ; Multiprotein Complexes - genetics ; Multiprotein Complexes - metabolism ; Nonsense Mediated mRNA Decay ; Peptide Chain Elongation, Translational ; Peptide Elongation Factors - chemistry ; Peptide Elongation Factors - genetics ; Peptide Elongation Factors - metabolism ; Protein Interaction Domains and Motifs ; quality control ; ribosomes ; Ribosomes - metabolism ; RNA Stability ; RNA, Fungal - genetics ; RNA, Fungal - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - chemistry ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; stalls ; translation (genetics)</subject><ispartof>Molecular cell, 2012-05, Vol.46 (4), p.518-529</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-64f9dfeb8c2a37d6b0fbd91179b393274c208b23e4d1f393be9507097f3ae0a03</citedby><cites>FETCH-LOGICAL-c483t-64f9dfeb8c2a37d6b0fbd91179b393274c208b23e4d1f393be9507097f3ae0a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molcel.2012.03.013$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22503425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuboi, Tatsuhisa</creatorcontrib><creatorcontrib>Kuroha, Kazushige</creatorcontrib><creatorcontrib>Kudo, Kazuhei</creatorcontrib><creatorcontrib>Makino, Shiho</creatorcontrib><creatorcontrib>Inoue, Eri</creatorcontrib><creatorcontrib>Kashima, Isao</creatorcontrib><creatorcontrib>Inada, Toshifumi</creatorcontrib><title>Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA</title><title>Molecular cell</title><addtitle>Mol Cell</addtitle><description>Translation arrest leads to an endonucleolytic cleavage of mRNA that is termed no-go decay (NGD). It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and dissociates subunits of a stalled ribosome in vitro. Here we report that Dom34:Hbs1 dissociates the subunits of a ribosome that is stalled at the 3′ end of mRNA in vivo, and has a crucial role in both NGD and nonstop decay. Dom34:Hbs1-mediated dissociation of a ribosome that is stalled at the 3′ end of mRNA is required for degradation of a 5′-NGD intermediate. Dom34:Hbs1 facilitates the decay of nonstop mRNAs from the 3′ end by exosomes and is required for the complete degradation of nonstop mRNA decay intermediates. We propose that Dom34:Hbs1 stimulates degradation of the 5′-NGD intermediate and of nonstop mRNA by dissociating the ribosome that is stalled at the 3′ end of the mRNA.
[Display omitted]
► Dom34:Hbs1 dissociates subunits of ribosome stalled at the 3′ end of mRNA in vivo ► Dom34:Hbs1 facilitates the decay of nonstop mRNA and 5′-NGD intermediate by exosome ► Ribosomes stalled at the 3′ end of mRNA induce sequential endonucleolytic cleavages ► Carboxy-terminal region of Ski7 and Dom34:Hbs1 play independent roles in NSD</description><subject>Adaptor Proteins, Signal Transducing - chemistry</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Base Sequence</subject><subject>Cell Cycle Proteins - chemistry</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>dissociation</subject><subject>Endoribonucleases - chemistry</subject><subject>Endoribonucleases - genetics</subject><subject>Endoribonucleases - metabolism</subject><subject>exosomes</subject><subject>GTP-Binding Proteins - chemistry</subject><subject>GTP-Binding Proteins - genetics</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>HSP70 Heat-Shock Proteins - chemistry</subject><subject>HSP70 Heat-Shock Proteins - genetics</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>messenger RNA</subject><subject>Multiprotein Complexes - chemistry</subject><subject>Multiprotein Complexes - genetics</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Nonsense Mediated mRNA Decay</subject><subject>Peptide Chain Elongation, Translational</subject><subject>Peptide Elongation Factors - chemistry</subject><subject>Peptide Elongation Factors - genetics</subject><subject>Peptide Elongation Factors - metabolism</subject><subject>Protein Interaction Domains and Motifs</subject><subject>quality control</subject><subject>ribosomes</subject><subject>Ribosomes - metabolism</subject><subject>RNA Stability</subject><subject>RNA, Fungal - genetics</subject><subject>RNA, Fungal - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - chemistry</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>stalls</subject><subject>translation (genetics)</subject><issn>1097-2765</issn><issn>1097-4164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAQxy0EomXhDRD4yCXBX0k2HJBW29JWqvjYpWfLdibglRO3thcpN3glHoknqVfZcuxpRqPff2b0Q-g1JSUltH6_KwfvDLiSEcpKwktC-RN0SknbFILW4umxZ01dnaAXMe4IoaJats_RCWMV4YJVp-jPmR-4-HCpI8VfnZoiVvgCRgjK4Y13gO2Iv-2Vs2kq1n5MwTu8nWKCIWI94TMbozdWJetH7Psc3iblHHR4Y7WPfgCsEk4_AfN_v__i87E7UCsNIagx4WHzefUSPeuVi_DqWBfo5tP59_Vlcf3l4mq9ui6MWPJU1KJvux700jDFm67WpNddS2nTat5y1gjDyFIzDqKjfZ5oaCvSZAE9V0AU4Qv0bt57G_zdHmKSg43Zn1Mj-H2UWWpTM8azxgUSM2qCjzFAL2-DHVSYMnTgarmTs3x5kC8JlzmVY2-OF_Z6gO5_6MF2Bt7OQK-8VD-CjfJmmzfUhBCWqTYTH2cCsolfFoKMxsJooLMBTJKdt4__cA_37aAO</recordid><startdate>20120525</startdate><enddate>20120525</enddate><creator>Tsuboi, Tatsuhisa</creator><creator>Kuroha, Kazushige</creator><creator>Kudo, Kazuhei</creator><creator>Makino, Shiho</creator><creator>Inoue, Eri</creator><creator>Kashima, Isao</creator><creator>Inada, Toshifumi</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120525</creationdate><title>Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA</title><author>Tsuboi, Tatsuhisa ; Kuroha, Kazushige ; Kudo, Kazuhei ; Makino, Shiho ; Inoue, Eri ; Kashima, Isao ; Inada, Toshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-64f9dfeb8c2a37d6b0fbd91179b393274c208b23e4d1f393be9507097f3ae0a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adaptor Proteins, Signal Transducing - chemistry</topic><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Base Sequence</topic><topic>Cell Cycle Proteins - chemistry</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>dissociation</topic><topic>Endoribonucleases - chemistry</topic><topic>Endoribonucleases - genetics</topic><topic>Endoribonucleases - metabolism</topic><topic>exosomes</topic><topic>GTP-Binding Proteins - chemistry</topic><topic>GTP-Binding Proteins - genetics</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>HSP70 Heat-Shock Proteins - chemistry</topic><topic>HSP70 Heat-Shock Proteins - genetics</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>messenger RNA</topic><topic>Multiprotein Complexes - chemistry</topic><topic>Multiprotein Complexes - genetics</topic><topic>Multiprotein Complexes - metabolism</topic><topic>Nonsense Mediated mRNA Decay</topic><topic>Peptide Chain Elongation, Translational</topic><topic>Peptide Elongation Factors - chemistry</topic><topic>Peptide Elongation Factors - genetics</topic><topic>Peptide Elongation Factors - metabolism</topic><topic>Protein Interaction Domains and Motifs</topic><topic>quality control</topic><topic>ribosomes</topic><topic>Ribosomes - metabolism</topic><topic>RNA Stability</topic><topic>RNA, Fungal - genetics</topic><topic>RNA, Fungal - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins - chemistry</topic><topic>Saccharomyces cerevisiae Proteins - genetics</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>stalls</topic><topic>translation (genetics)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuboi, Tatsuhisa</creatorcontrib><creatorcontrib>Kuroha, Kazushige</creatorcontrib><creatorcontrib>Kudo, Kazuhei</creatorcontrib><creatorcontrib>Makino, Shiho</creatorcontrib><creatorcontrib>Inoue, Eri</creatorcontrib><creatorcontrib>Kashima, Isao</creatorcontrib><creatorcontrib>Inada, Toshifumi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuboi, Tatsuhisa</au><au>Kuroha, Kazushige</au><au>Kudo, Kazuhei</au><au>Makino, Shiho</au><au>Inoue, Eri</au><au>Kashima, Isao</au><au>Inada, Toshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA</atitle><jtitle>Molecular cell</jtitle><addtitle>Mol Cell</addtitle><date>2012-05-25</date><risdate>2012</risdate><volume>46</volume><issue>4</issue><spage>518</spage><epage>529</epage><pages>518-529</pages><issn>1097-2765</issn><eissn>1097-4164</eissn><abstract>Translation arrest leads to an endonucleolytic cleavage of mRNA that is termed no-go decay (NGD). It has been reported that the Dom34:Hbs1 complex stimulates this endonucleolytic cleavage of mRNA induced by translation arrest in vivo and dissociates subunits of a stalled ribosome in vitro. Here we report that Dom34:Hbs1 dissociates the subunits of a ribosome that is stalled at the 3′ end of mRNA in vivo, and has a crucial role in both NGD and nonstop decay. Dom34:Hbs1-mediated dissociation of a ribosome that is stalled at the 3′ end of mRNA is required for degradation of a 5′-NGD intermediate. Dom34:Hbs1 facilitates the decay of nonstop mRNAs from the 3′ end by exosomes and is required for the complete degradation of nonstop mRNA decay intermediates. We propose that Dom34:Hbs1 stimulates degradation of the 5′-NGD intermediate and of nonstop mRNA by dissociating the ribosome that is stalled at the 3′ end of the mRNA.
[Display omitted]
► Dom34:Hbs1 dissociates subunits of ribosome stalled at the 3′ end of mRNA in vivo ► Dom34:Hbs1 facilitates the decay of nonstop mRNA and 5′-NGD intermediate by exosome ► Ribosomes stalled at the 3′ end of mRNA induce sequential endonucleolytic cleavages ► Carboxy-terminal region of Ski7 and Dom34:Hbs1 play independent roles in NSD</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22503425</pmid><doi>10.1016/j.molcel.2012.03.013</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Base Sequence Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism dissociation Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism exosomes GTP-Binding Proteins - chemistry GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HSP70 Heat-Shock Proteins - chemistry HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism messenger RNA Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nonsense Mediated mRNA Decay Peptide Chain Elongation, Translational Peptide Elongation Factors - chemistry Peptide Elongation Factors - genetics Peptide Elongation Factors - metabolism Protein Interaction Domains and Motifs quality control ribosomes Ribosomes - metabolism RNA Stability RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism stalls translation (genetics) |
| title | Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA |
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