Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats
Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of d -galactose induced a...
Gespeichert in:
| Veröffentlicht in: | Biogerontology (Dordrecht) 2012-06, Vol.13 (3), p.251-260 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 260 |
|---|---|
| container_issue | 3 |
| container_start_page | 251 |
| container_title | Biogerontology (Dordrecht) |
| container_volume | 13 |
| creator | Aydın, Seval Yanar, Karolin Atukeren, Pınar Dalo, Enis Sitar, Mustafa Erinç Uslu, Ezel Caf, Nazlı Çakatay, Ufuk |
| description | Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of
d
-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of
d
-galactose (60 mg/kg/day) for 6 weeks to young male Sprague–Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2′deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In
d
-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing. |
| doi_str_mv | 10.1007/s10522-011-9370-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1017615992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017615992</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-32eab57338dc59b4d9a21006f290f550ee59c012313ffe2c0637179a85426ace3</originalsourceid><addsrcrecordid>eNp1kUuLFDEQx4Mo7kM_gBcJiODBaB6dpHOUwcfCwl7Wc1OTrh6y9nTGVPfifHszzvhgwVMV1K8e__oz9kLJd0pK_56UtFoLqZQIxkthHrFzZb0Rzrv2cc1NG4T1OpyxC6I7KZXTzj5lZ1orH3yw52y3ytsdlER54nng-UfqYU73yGkuSMTXKW-hfMNCPE284AQjnxPRgnTge7GBEeKcCWu9XyL2b_kE81JgHPccNthzmHq-z8u04QVmesaeDDASPj_FS_b108fb1RdxffP5avXhWsRG6lkYjbCuUkzbRxvWTR9AV81u0EEO1kpEG6JU2igzDKijdMZXTdDaRjuIaC7Zm-PcXcnf67Vzt00UcRxhwrxQp6TyTtkQdEVfPUDv8lKq0l-Uaxrp1YFSRyqWTFRw6HYl1d_sK9Qd7OiOdnTVju5gR2dqz8vT5GW9xf5Px-__V-D1CQCKMA4FppjoL2eDt0q1ldNHjmpp2mD598T_bf8JbQeh4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1016440712</pqid></control><display><type>article</type><title>Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Aydın, Seval ; Yanar, Karolin ; Atukeren, Pınar ; Dalo, Enis ; Sitar, Mustafa Erinç ; Uslu, Ezel ; Caf, Nazlı ; Çakatay, Ufuk</creator><creatorcontrib>Aydın, Seval ; Yanar, Karolin ; Atukeren, Pınar ; Dalo, Enis ; Sitar, Mustafa Erinç ; Uslu, Ezel ; Caf, Nazlı ; Çakatay, Ufuk</creatorcontrib><description>Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of
d
-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of
d
-galactose (60 mg/kg/day) for 6 weeks to young male Sprague–Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2′deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In
d
-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-011-9370-3</identifier><identifier>PMID: 22179795</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aging ; Aging - metabolism ; Animals ; Biological and medical sciences ; Biomarkers ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Cell Biology ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - metabolism ; Development. Metamorphosis. Moult. Ageing ; Developmental Biology ; DNA damage ; Fundamental and applied biological sciences. Psychology ; Galactose - pharmacology ; Geriatrics/Gerontology ; Homeostasis ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Life Sciences ; Lipid Peroxides - metabolism ; Lipids ; Male ; Malondialdehyde - metabolism ; Medical research ; Oxidation ; Oxidative Stress ; Production increases ; Proteins ; Rats ; Rats, Sprague-Dawley ; Research Article ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Biogerontology (Dordrecht), 2012-06, Vol.13 (3), p.251-260</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-32eab57338dc59b4d9a21006f290f550ee59c012313ffe2c0637179a85426ace3</citedby><cites>FETCH-LOGICAL-c402t-32eab57338dc59b4d9a21006f290f550ee59c012313ffe2c0637179a85426ace3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-011-9370-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-011-9370-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25975118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22179795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydın, Seval</creatorcontrib><creatorcontrib>Yanar, Karolin</creatorcontrib><creatorcontrib>Atukeren, Pınar</creatorcontrib><creatorcontrib>Dalo, Enis</creatorcontrib><creatorcontrib>Sitar, Mustafa Erinç</creatorcontrib><creatorcontrib>Uslu, Ezel</creatorcontrib><creatorcontrib>Caf, Nazlı</creatorcontrib><creatorcontrib>Çakatay, Ufuk</creatorcontrib><title>Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of
d
-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of
d
-galactose (60 mg/kg/day) for 6 weeks to young male Sprague–Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2′deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In
d
-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.</description><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - metabolism</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Developmental Biology</subject><subject>DNA damage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galactose - pharmacology</subject><subject>Geriatrics/Gerontology</subject><subject>Homeostasis</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lipid Peroxides - metabolism</subject><subject>Lipids</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical research</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Production increases</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUuLFDEQx4Mo7kM_gBcJiODBaB6dpHOUwcfCwl7Wc1OTrh6y9nTGVPfifHszzvhgwVMV1K8e__oz9kLJd0pK_56UtFoLqZQIxkthHrFzZb0Rzrv2cc1NG4T1OpyxC6I7KZXTzj5lZ1orH3yw52y3ytsdlER54nng-UfqYU73yGkuSMTXKW-hfMNCPE284AQjnxPRgnTge7GBEeKcCWu9XyL2b_kE81JgHPccNthzmHq-z8u04QVmesaeDDASPj_FS_b108fb1RdxffP5avXhWsRG6lkYjbCuUkzbRxvWTR9AV81u0EEO1kpEG6JU2igzDKijdMZXTdDaRjuIaC7Zm-PcXcnf67Vzt00UcRxhwrxQp6TyTtkQdEVfPUDv8lKq0l-Uaxrp1YFSRyqWTFRw6HYl1d_sK9Qd7OiOdnTVju5gR2dqz8vT5GW9xf5Px-__V-D1CQCKMA4FppjoL2eDt0q1ldNHjmpp2mD598T_bf8JbQeh4w</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Aydın, Seval</creator><creator>Yanar, Karolin</creator><creator>Atukeren, Pınar</creator><creator>Dalo, Enis</creator><creator>Sitar, Mustafa Erinç</creator><creator>Uslu, Ezel</creator><creator>Caf, Nazlı</creator><creator>Çakatay, Ufuk</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats</title><author>Aydın, Seval ; Yanar, Karolin ; Atukeren, Pınar ; Dalo, Enis ; Sitar, Mustafa Erinç ; Uslu, Ezel ; Caf, Nazlı ; Çakatay, Ufuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-32eab57338dc59b4d9a21006f290f550ee59c012313ffe2c0637179a85426ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - metabolism</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Developmental Biology</topic><topic>DNA damage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galactose - pharmacology</topic><topic>Geriatrics/Gerontology</topic><topic>Homeostasis</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Lipid Peroxides - metabolism</topic><topic>Lipids</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical research</topic><topic>Oxidation</topic><topic>Oxidative Stress</topic><topic>Production increases</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research Article</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydın, Seval</creatorcontrib><creatorcontrib>Yanar, Karolin</creatorcontrib><creatorcontrib>Atukeren, Pınar</creatorcontrib><creatorcontrib>Dalo, Enis</creatorcontrib><creatorcontrib>Sitar, Mustafa Erinç</creatorcontrib><creatorcontrib>Uslu, Ezel</creatorcontrib><creatorcontrib>Caf, Nazlı</creatorcontrib><creatorcontrib>Çakatay, Ufuk</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydın, Seval</au><au>Yanar, Karolin</au><au>Atukeren, Pınar</au><au>Dalo, Enis</au><au>Sitar, Mustafa Erinç</au><au>Uslu, Ezel</au><au>Caf, Nazlı</au><au>Çakatay, Ufuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>13</volume><issue>3</issue><spage>251</spage><epage>260</epage><pages>251-260</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Ageing of kidneys is a clinical health issue of the society. Age-related renal insufficiency has important implications due to impaired redox homeostasis. We examined protein, DNA and lipid oxidation biomarkers as well as protein-bound sialic acid (SA) in the kidney tissues of
d
-galactose induced ageing rats, naturally aged rats and their corresponding young control group. Intraperitoneal injection of
d
-galactose (60 mg/kg/day) for 6 weeks to young male Sprague–Dawley rats (20-week-old) was used to establish mimetic ageing model. In this study, we investigated the levels of protein carbonyl groups (PCO), various thiol fractions such as total thiol groups (T-SH), protein (P-SH) and non-protein thiol groups (NP-SH), lipid oxidation parameters such as lipid hydroperoxides (LHP) and malondialdehyde (MDA), SA and 8-hydroxy-2′deoxyguanosine (8-OHdG) parameters for comparison of naturally aged, induced aged and young rats. In
d
-galactose induced aged group, PCO, LHP, MDA, and 8-OHdG concentrations were significantly higher than young control group, whereas T-SH, P-SH levels were significantly lower than the young rats. In addition, NP-SH and SA concentrations were similar between the mimetic ageing and young control groups. In naturally ageing rats, PCO and MDA levels were significantly higher, whereas T-SH, P-SH, NP-SH concentrations were low compared to young controls. On the other hand, SA and 8-OHdG levels were not different between the naturally ageing group and the young control group. Our results demonstrated that the rats in the mimetic ageing group, have significant similarities with the naturally aged rats in terms of impaired redox homeostasis and can be used as a reliable animal model for renal ageing.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22179795</pmid><doi>10.1007/s10522-011-9370-3</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1389-5729 |
| ispartof | Biogerontology (Dordrecht), 2012-06, Vol.13 (3), p.251-260 |
| issn | 1389-5729 1573-6768 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1017615992 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aging Aging - metabolism Animals Biological and medical sciences Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Cell Biology Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Development. Metamorphosis. Moult. Ageing Developmental Biology DNA damage Fundamental and applied biological sciences. Psychology Galactose - pharmacology Geriatrics/Gerontology Homeostasis Kidney - drug effects Kidney - metabolism Kidneys Life Sciences Lipid Peroxides - metabolism Lipids Male Malondialdehyde - metabolism Medical research Oxidation Oxidative Stress Production increases Proteins Rats Rats, Sprague-Dawley Research Article Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Comparison of oxidative stress biomarkers in renal tissues of d-galactose induced, naturally aged and young rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T10%3A00%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20oxidative%20stress%20biomarkers%20in%20renal%20tissues%20of%20d-galactose%20induced,%20naturally%20aged%20and%20young%20rats&rft.jtitle=Biogerontology%20(Dordrecht)&rft.au=Ayd%C4%B1n,%20Seval&rft.date=2012-06-01&rft.volume=13&rft.issue=3&rft.spage=251&rft.epage=260&rft.pages=251-260&rft.issn=1389-5729&rft.eissn=1573-6768&rft_id=info:doi/10.1007/s10522-011-9370-3&rft_dat=%3Cproquest_cross%3E1017615992%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1016440712&rft_id=info:pmid/22179795&rfr_iscdi=true |