Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis
Abstract Background The role of neurotrophins in allergic rhinitis (AR) has been well studied, but it has not been evaluated in idiopathic rhinitis (IR). Objective We aimed to evaluate the nasal β-nerve growth factor (β-NGF) expressions of mast cells in patients with AR and IR. Methods Seventeen pat...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 2012-06, Vol.108 (6), p.396-401 |
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| creator | Gelincik, Aslı, MD Aydın, Filiz, MD Özerman, Bilge, MD Ergüven, Mine, MD Aydın, Salih, MD Bilir, Ayhan, MD Genç, Sema, MD Eroğlu, Hacer, MD Çolakoğlu, Bahattin, MD Erden, Sacide, MD Büyüköztürk, Suna, MD |
| description | Abstract Background The role of neurotrophins in allergic rhinitis (AR) has been well studied, but it has not been evaluated in idiopathic rhinitis (IR). Objective We aimed to evaluate the nasal β-nerve growth factor (β-NGF) expressions of mast cells in patients with AR and IR. Methods Seventeen patients with house dust mites–induced persistent moderate/severe allergic rhinitis (mean age: 29.7 ± 11.96), 14 patients with idiopathic rhinitis (mean age, 29.3 ± 10.62), and 16 healthy controls (29.9 ± 11.57) were included in the study. Nasal biopsy specimens were taken from the posterior part of the inferior turbinate from all of the study subjects. Nasal β-nerve growth factor and its receptors, pan-neurotrophin receptor p75, and tyrosine kinase A (trkA) were assessed with an immunofluorescence assay. Mast cells were determined by both an immunofluorescence assay and immunohistochemistry as tryptase-positive cells. Results The β-NGF, trkA, and p75 receptor counts were significantly higher in AR and IR patients than in the control group ( P < .001, for each), but they were not different between AR and IR patients. Similarly, the ratio of β-NGF+ mast cells/total mast cells and the ratio of β-NGF+ mast cells/total β-NGF+ cells in AR and IR patients was found to be elevated when compared with the control group ( P < .001, P < .001, P < .001, and P = .046, respectively); furthermore, the 2 ratios were not statistically different between the 2 patient groups. Conclusion The increase in β-NGF–expressing mast cells does not differ between idiopathic and allergic rhinitis. Therefore, we propose that mast cells do play a role in the pathogenesis of IR as important as in that of AR. |
| doi_str_mv | 10.1016/j.anai.2012.04.006 |
| format | Article |
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Objective We aimed to evaluate the nasal β-nerve growth factor (β-NGF) expressions of mast cells in patients with AR and IR. Methods Seventeen patients with house dust mites–induced persistent moderate/severe allergic rhinitis (mean age: 29.7 ± 11.96), 14 patients with idiopathic rhinitis (mean age, 29.3 ± 10.62), and 16 healthy controls (29.9 ± 11.57) were included in the study. Nasal biopsy specimens were taken from the posterior part of the inferior turbinate from all of the study subjects. Nasal β-nerve growth factor and its receptors, pan-neurotrophin receptor p75, and tyrosine kinase A (trkA) were assessed with an immunofluorescence assay. Mast cells were determined by both an immunofluorescence assay and immunohistochemistry as tryptase-positive cells. Results The β-NGF, trkA, and p75 receptor counts were significantly higher in AR and IR patients than in the control group ( P < .001, for each), but they were not different between AR and IR patients. Similarly, the ratio of β-NGF+ mast cells/total mast cells and the ratio of β-NGF+ mast cells/total β-NGF+ cells in AR and IR patients was found to be elevated when compared with the control group ( P < .001, P < .001, P < .001, and P = .046, respectively); furthermore, the 2 ratios were not statistically different between the 2 patient groups. Conclusion The increase in β-NGF–expressing mast cells does not differ between idiopathic and allergic rhinitis. Therefore, we propose that mast cells do play a role in the pathogenesis of IR as important as in that of AR.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/j.anai.2012.04.006</identifier><identifier>PMID: 22626591</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergy and Immunology ; Biological and medical sciences ; Case-Control Studies ; Cell Count ; Dermatology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Expression ; Humans ; Male ; Mast Cells - cytology ; Mast Cells - immunology ; Mast Cells - metabolism ; Medical sciences ; Nasal Mucosa - immunology ; Nasal Mucosa - physiopathology ; Nerve Growth Factor - genetics ; Nerve Growth Factor - immunology ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Receptor, Nerve Growth Factor - genetics ; Receptor, Nerve Growth Factor - immunology ; Receptor, trkA - genetics ; Receptor, trkA - immunology ; Rhinitis, Allergic, Perennial - genetics ; Rhinitis, Allergic, Perennial - immunology ; Rhinitis, Allergic, Perennial - physiopathology ; Rhinitis, Vasomotor - genetics ; Rhinitis, Vasomotor - immunology ; Rhinitis, Vasomotor - physiopathology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Turkey ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Annals of allergy, asthma, & immunology, 2012-06, Vol.108 (6), p.396-401</ispartof><rights>American College of Allergy, Asthma & Immunology</rights><rights>2012 American College of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-df7a17a4734b8f359414a06b36805cce26b4df6c1fc948fba4c093793c85b66f3</citedby><cites>FETCH-LOGICAL-c441t-df7a17a4734b8f359414a06b36805cce26b4df6c1fc948fba4c093793c85b66f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anai.2012.04.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26002862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22626591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gelincik, Aslı, MD</creatorcontrib><creatorcontrib>Aydın, Filiz, MD</creatorcontrib><creatorcontrib>Özerman, Bilge, MD</creatorcontrib><creatorcontrib>Ergüven, Mine, MD</creatorcontrib><creatorcontrib>Aydın, Salih, MD</creatorcontrib><creatorcontrib>Bilir, Ayhan, MD</creatorcontrib><creatorcontrib>Genç, Sema, MD</creatorcontrib><creatorcontrib>Eroğlu, Hacer, MD</creatorcontrib><creatorcontrib>Çolakoğlu, Bahattin, MD</creatorcontrib><creatorcontrib>Erden, Sacide, MD</creatorcontrib><creatorcontrib>Büyüköztürk, Suna, MD</creatorcontrib><title>Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Abstract Background The role of neurotrophins in allergic rhinitis (AR) has been well studied, but it has not been evaluated in idiopathic rhinitis (IR). Objective We aimed to evaluate the nasal β-nerve growth factor (β-NGF) expressions of mast cells in patients with AR and IR. Methods Seventeen patients with house dust mites–induced persistent moderate/severe allergic rhinitis (mean age: 29.7 ± 11.96), 14 patients with idiopathic rhinitis (mean age, 29.3 ± 10.62), and 16 healthy controls (29.9 ± 11.57) were included in the study. Nasal biopsy specimens were taken from the posterior part of the inferior turbinate from all of the study subjects. Nasal β-nerve growth factor and its receptors, pan-neurotrophin receptor p75, and tyrosine kinase A (trkA) were assessed with an immunofluorescence assay. Mast cells were determined by both an immunofluorescence assay and immunohistochemistry as tryptase-positive cells. Results The β-NGF, trkA, and p75 receptor counts were significantly higher in AR and IR patients than in the control group ( P < .001, for each), but they were not different between AR and IR patients. Similarly, the ratio of β-NGF+ mast cells/total mast cells and the ratio of β-NGF+ mast cells/total β-NGF+ cells in AR and IR patients was found to be elevated when compared with the control group ( P < .001, P < .001, P < .001, and P = .046, respectively); furthermore, the 2 ratios were not statistically different between the 2 patient groups. Conclusion The increase in β-NGF–expressing mast cells does not differ between idiopathic and allergic rhinitis. Therefore, we propose that mast cells do play a role in the pathogenesis of IR as important as in that of AR.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Male</subject><subject>Mast Cells - cytology</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>Nasal Mucosa - immunology</subject><subject>Nasal Mucosa - physiopathology</subject><subject>Nerve Growth Factor - genetics</subject><subject>Nerve Growth Factor - immunology</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Receptor, Nerve Growth Factor - genetics</subject><subject>Receptor, Nerve Growth Factor - immunology</subject><subject>Receptor, trkA - genetics</subject><subject>Receptor, trkA - immunology</subject><subject>Rhinitis, Allergic, Perennial - genetics</subject><subject>Rhinitis, Allergic, Perennial - immunology</subject><subject>Rhinitis, Allergic, Perennial - physiopathology</subject><subject>Rhinitis, Vasomotor - genetics</subject><subject>Rhinitis, Vasomotor - immunology</subject><subject>Rhinitis, Vasomotor - physiopathology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Turkey</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1081-1206</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkuLFDEURgtRnHH0D7iQbAQ3VeZVqSoQQYbxAQMu1HVIpW6601YnbW56Zhr88ZOyWwUXLkISON9NcnKr6jmjDaNMvd40JhjfcMp4Q2VDqXpQnbNWyFpKoR6WNe1ZzThVZ9UTxA2llPVKPK7OOFdctQM7r35ehbUJFiYSIN0AWaV4m9fEGZtjInC3S4DoYyDjgWwNZmJhnpFMEZCEmMnknYNE0K-Cd96akOcDGSHfAgTiJx93Jq-9JSZMxMwzpFXZpLUPPnt8Wj1yZkZ4dpovqm_vr75efqyvP3_4dPnuurZSslxPrjOsM7ITcuydaAfJpKFqFKqnrbXA1SgnpyxzdpC9G420dBDdIGzfjko5cVG9OtbdpfhjD5j11uPyEBMg7lEvNlWneD8UlB9RmyJiAqd3yW9NOhToF6c3erGuF-uaSl2sl9CLU_39uIXpT-S35gK8PAEGrZldKso9_uUUpbxXvHBvjhwUGzcekkbrYfken8BmPUX__3u8_Sdu52K6nPgdDoCbuE-heNZMY8noL0t_LO1RBuVKtuIe5rW29A</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Gelincik, Aslı, MD</creator><creator>Aydın, Filiz, MD</creator><creator>Özerman, Bilge, MD</creator><creator>Ergüven, Mine, MD</creator><creator>Aydın, Salih, MD</creator><creator>Bilir, Ayhan, MD</creator><creator>Genç, Sema, MD</creator><creator>Eroğlu, Hacer, MD</creator><creator>Çolakoğlu, Bahattin, MD</creator><creator>Erden, Sacide, MD</creator><creator>Büyüköztürk, Suna, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis</title><author>Gelincik, Aslı, MD ; Aydın, Filiz, MD ; Özerman, Bilge, MD ; Ergüven, Mine, MD ; Aydın, Salih, MD ; Bilir, Ayhan, MD ; Genç, Sema, MD ; Eroğlu, Hacer, MD ; Çolakoğlu, Bahattin, MD ; Erden, Sacide, MD ; Büyüköztürk, Suna, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-df7a17a4734b8f359414a06b36805cce26b4df6c1fc948fba4c093793c85b66f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Male</topic><topic>Mast Cells - cytology</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>Nasal Mucosa - immunology</topic><topic>Nasal Mucosa - physiopathology</topic><topic>Nerve Growth Factor - genetics</topic><topic>Nerve Growth Factor - immunology</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Receptor, Nerve Growth Factor - genetics</topic><topic>Receptor, Nerve Growth Factor - immunology</topic><topic>Receptor, trkA - genetics</topic><topic>Receptor, trkA - immunology</topic><topic>Rhinitis, Allergic, Perennial - genetics</topic><topic>Rhinitis, Allergic, Perennial - immunology</topic><topic>Rhinitis, Allergic, Perennial - physiopathology</topic><topic>Rhinitis, Vasomotor - genetics</topic><topic>Rhinitis, Vasomotor - immunology</topic><topic>Rhinitis, Vasomotor - physiopathology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Turkey</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gelincik, Aslı, MD</creatorcontrib><creatorcontrib>Aydın, Filiz, MD</creatorcontrib><creatorcontrib>Özerman, Bilge, MD</creatorcontrib><creatorcontrib>Ergüven, Mine, MD</creatorcontrib><creatorcontrib>Aydın, Salih, MD</creatorcontrib><creatorcontrib>Bilir, Ayhan, MD</creatorcontrib><creatorcontrib>Genç, Sema, MD</creatorcontrib><creatorcontrib>Eroğlu, Hacer, MD</creatorcontrib><creatorcontrib>Çolakoğlu, Bahattin, MD</creatorcontrib><creatorcontrib>Erden, Sacide, MD</creatorcontrib><creatorcontrib>Büyüköztürk, Suna, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gelincik, Aslı, MD</au><au>Aydın, Filiz, MD</au><au>Özerman, Bilge, MD</au><au>Ergüven, Mine, MD</au><au>Aydın, Salih, MD</au><au>Bilir, Ayhan, MD</au><au>Genç, Sema, MD</au><au>Eroğlu, Hacer, MD</au><au>Çolakoğlu, Bahattin, MD</au><au>Erden, Sacide, MD</au><au>Büyüköztürk, Suna, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>108</volume><issue>6</issue><spage>396</spage><epage>401</epage><pages>396-401</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><abstract>Abstract Background The role of neurotrophins in allergic rhinitis (AR) has been well studied, but it has not been evaluated in idiopathic rhinitis (IR). Objective We aimed to evaluate the nasal β-nerve growth factor (β-NGF) expressions of mast cells in patients with AR and IR. Methods Seventeen patients with house dust mites–induced persistent moderate/severe allergic rhinitis (mean age: 29.7 ± 11.96), 14 patients with idiopathic rhinitis (mean age, 29.3 ± 10.62), and 16 healthy controls (29.9 ± 11.57) were included in the study. Nasal biopsy specimens were taken from the posterior part of the inferior turbinate from all of the study subjects. Nasal β-nerve growth factor and its receptors, pan-neurotrophin receptor p75, and tyrosine kinase A (trkA) were assessed with an immunofluorescence assay. Mast cells were determined by both an immunofluorescence assay and immunohistochemistry as tryptase-positive cells. Results The β-NGF, trkA, and p75 receptor counts were significantly higher in AR and IR patients than in the control group ( P < .001, for each), but they were not different between AR and IR patients. Similarly, the ratio of β-NGF+ mast cells/total mast cells and the ratio of β-NGF+ mast cells/total β-NGF+ cells in AR and IR patients was found to be elevated when compared with the control group ( P < .001, P < .001, P < .001, and P = .046, respectively); furthermore, the 2 ratios were not statistically different between the 2 patient groups. Conclusion The increase in β-NGF–expressing mast cells does not differ between idiopathic and allergic rhinitis. Therefore, we propose that mast cells do play a role in the pathogenesis of IR as important as in that of AR.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22626591</pmid><doi>10.1016/j.anai.2012.04.006</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of allergy, asthma, & immunology, 2012-06, Vol.108 (6), p.396-401 |
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| subjects | Adolescent Adult Allergy and Immunology Biological and medical sciences Case-Control Studies Cell Count Dermatology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Humans Male Mast Cells - cytology Mast Cells - immunology Mast Cells - metabolism Medical sciences Nasal Mucosa - immunology Nasal Mucosa - physiopathology Nerve Growth Factor - genetics Nerve Growth Factor - immunology Non tumoral diseases Otorhinolaryngology. Stomatology Receptor, Nerve Growth Factor - genetics Receptor, Nerve Growth Factor - immunology Receptor, trkA - genetics Receptor, trkA - immunology Rhinitis, Allergic, Perennial - genetics Rhinitis, Allergic, Perennial - immunology Rhinitis, Allergic, Perennial - physiopathology Rhinitis, Vasomotor - genetics Rhinitis, Vasomotor - immunology Rhinitis, Vasomotor - physiopathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Turkey Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Enhanced nerve growth factor expression by mast cells does not differ significantly between idiopathic and allergic rhinitis |
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