Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study
Background There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography. Objectives The aim of this study was to investigate the ef...
Gespeichert in:
| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2012-06, Vol.26 (6), p.778-781 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 781 |
|---|---|
| container_issue | 6 |
| container_start_page | 778 |
| container_title | Journal of the European Academy of Dermatology and Venereology |
| container_volume | 26 |
| creator | Ismailogullari, S Ferahbas, A Aksu, M Baydemir, R Utas, S |
| description | Background There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography.
Objectives The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG).
Patients and methods Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5 mg/kg of isotretinoin. Clinician‐administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment.
Results Sleep efficiency was increased from 83.5% (62.8–89.0%, quartiles) to 89.5% (81.5–93.5%, quartiles; P = 0.036) and sleep latency decreased from 18.0 min (11.1–36.3, quartiles) to 15.5 min (9.3–19.0, quartiles; P = 0.023) following 1‐month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale.
Conclusions This study suggests that isotretinoin treatment slightly improves night‐time sleep without any effects on sleep stages and daytime sleepiness. |
| doi_str_mv | 10.1111/j.1468-3083.2011.04095.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1016672877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1016672877</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4075-e3b84523a78aa36dadbed71d95bd55766126485abb64bbd90eedcbb66e3241553</originalsourceid><addsrcrecordid>eNqNkMtu2zAQRYmiQeI4-YWCy26kkuJLKtBF4aZOkyBZ5GGgG4ISRyhdWVJEurH_vlTseB1uODM8dwgchDAlKY3nyzKlXOYJIzlLM0JpSjgpRLr5gCaHh49oQopMJkUhihN06v2SkIiK_BidZFRwITifoKeLuoYqeNzV2PkuDBBc27kWx8qEFbQBdy32DUCP47Q3wcWZxy8u_MEe_sEA2FQtfMUG967pAvZhbbdn6Kg2jYfz_T1Fjz8vHmaXyc3d_Nfs-01ScaJEAqzMuciYUbkxTFpjS7CK2kKUVgglJc0kz4UpS8nL0hYEwFaxkcAyToVgU_R5t7cfuuc1-KBXzlfQNKaFbu01JVRKleVKRTTfodXQeT9ArfvBrcywjZAereqlHuXpUZ4erepXq3oTo5_2v6zLFdhD8E1jBL7tgBfXwPbdi_XVj6exivlkl3c-wOaQN8NfLRVTQi9u5_p-UfxeXC_u9TX7D287lfg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1016672877</pqid></control><display><type>article</type><title>Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ismailogullari, S ; Ferahbas, A ; Aksu, M ; Baydemir, R ; Utas, S</creator><creatorcontrib>Ismailogullari, S ; Ferahbas, A ; Aksu, M ; Baydemir, R ; Utas, S</creatorcontrib><description>Background There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography.
Objectives The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG).
Patients and methods Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5 mg/kg of isotretinoin. Clinician‐administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment.
Results Sleep efficiency was increased from 83.5% (62.8–89.0%, quartiles) to 89.5% (81.5–93.5%, quartiles; P = 0.036) and sleep latency decreased from 18.0 min (11.1–36.3, quartiles) to 15.5 min (9.3–19.0, quartiles; P = 0.023) following 1‐month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale.
Conclusions This study suggests that isotretinoin treatment slightly improves night‐time sleep without any effects on sleep stages and daytime sleepiness.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/j.1468-3083.2011.04095.x</identifier><identifier>PMID: 21545544</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acne Vulgaris - drug therapy ; Adolescent ; Adult ; Dermatologic Agents - adverse effects ; Dermatologic Agents - therapeutic use ; Female ; Humans ; Isotretinoin - adverse effects ; Isotretinoin - therapeutic use ; Male ; Pilot Projects ; Polysomnography ; Sleep - drug effects ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2012-06, Vol.26 (6), p.778-781</ispartof><rights>2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology</rights><rights>2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4075-e3b84523a78aa36dadbed71d95bd55766126485abb64bbd90eedcbb66e3241553</citedby><cites>FETCH-LOGICAL-c4075-e3b84523a78aa36dadbed71d95bd55766126485abb64bbd90eedcbb66e3241553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-3083.2011.04095.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-3083.2011.04095.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21545544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ismailogullari, S</creatorcontrib><creatorcontrib>Ferahbas, A</creatorcontrib><creatorcontrib>Aksu, M</creatorcontrib><creatorcontrib>Baydemir, R</creatorcontrib><creatorcontrib>Utas, S</creatorcontrib><title>Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography.
Objectives The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG).
Patients and methods Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5 mg/kg of isotretinoin. Clinician‐administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment.
Results Sleep efficiency was increased from 83.5% (62.8–89.0%, quartiles) to 89.5% (81.5–93.5%, quartiles; P = 0.036) and sleep latency decreased from 18.0 min (11.1–36.3, quartiles) to 15.5 min (9.3–19.0, quartiles; P = 0.023) following 1‐month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale.
Conclusions This study suggests that isotretinoin treatment slightly improves night‐time sleep without any effects on sleep stages and daytime sleepiness.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Dermatologic Agents - adverse effects</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Isotretinoin - adverse effects</subject><subject>Isotretinoin - therapeutic use</subject><subject>Male</subject><subject>Pilot Projects</subject><subject>Polysomnography</subject><subject>Sleep - drug effects</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu2zAQRYmiQeI4-YWCy26kkuJLKtBF4aZOkyBZ5GGgG4ISRyhdWVJEurH_vlTseB1uODM8dwgchDAlKY3nyzKlXOYJIzlLM0JpSjgpRLr5gCaHh49oQopMJkUhihN06v2SkIiK_BidZFRwITifoKeLuoYqeNzV2PkuDBBc27kWx8qEFbQBdy32DUCP47Q3wcWZxy8u_MEe_sEA2FQtfMUG967pAvZhbbdn6Kg2jYfz_T1Fjz8vHmaXyc3d_Nfs-01ScaJEAqzMuciYUbkxTFpjS7CK2kKUVgglJc0kz4UpS8nL0hYEwFaxkcAyToVgU_R5t7cfuuc1-KBXzlfQNKaFbu01JVRKleVKRTTfodXQeT9ArfvBrcywjZAereqlHuXpUZ4erepXq3oTo5_2v6zLFdhD8E1jBL7tgBfXwPbdi_XVj6exivlkl3c-wOaQN8NfLRVTQi9u5_p-UfxeXC_u9TX7D287lfg</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Ismailogullari, S</creator><creator>Ferahbas, A</creator><creator>Aksu, M</creator><creator>Baydemir, R</creator><creator>Utas, S</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study</title><author>Ismailogullari, S ; Ferahbas, A ; Aksu, M ; Baydemir, R ; Utas, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4075-e3b84523a78aa36dadbed71d95bd55766126485abb64bbd90eedcbb66e3241553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Dermatologic Agents - adverse effects</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Isotretinoin - adverse effects</topic><topic>Isotretinoin - therapeutic use</topic><topic>Male</topic><topic>Pilot Projects</topic><topic>Polysomnography</topic><topic>Sleep - drug effects</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ismailogullari, S</creatorcontrib><creatorcontrib>Ferahbas, A</creatorcontrib><creatorcontrib>Aksu, M</creatorcontrib><creatorcontrib>Baydemir, R</creatorcontrib><creatorcontrib>Utas, S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ismailogullari, S</au><au>Ferahbas, A</au><au>Aksu, M</au><au>Baydemir, R</au><au>Utas, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>26</volume><issue>6</issue><spage>778</spage><epage>781</epage><pages>778-781</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography.
Objectives The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG).
Patients and methods Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5 mg/kg of isotretinoin. Clinician‐administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment.
Results Sleep efficiency was increased from 83.5% (62.8–89.0%, quartiles) to 89.5% (81.5–93.5%, quartiles; P = 0.036) and sleep latency decreased from 18.0 min (11.1–36.3, quartiles) to 15.5 min (9.3–19.0, quartiles; P = 0.023) following 1‐month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale.
Conclusions This study suggests that isotretinoin treatment slightly improves night‐time sleep without any effects on sleep stages and daytime sleepiness.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21545544</pmid><doi>10.1111/j.1468-3083.2011.04095.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0926-9959 |
| ispartof | Journal of the European Academy of Dermatology and Venereology, 2012-06, Vol.26 (6), p.778-781 |
| issn | 0926-9959 1468-3083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1016672877 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acne Vulgaris - drug therapy Adolescent Adult Dermatologic Agents - adverse effects Dermatologic Agents - therapeutic use Female Humans Isotretinoin - adverse effects Isotretinoin - therapeutic use Male Pilot Projects Polysomnography Sleep - drug effects Surveys and Questionnaires Young Adult |
| title | Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T16%3A03%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20isotretinoin%20treatment%20on%20sleep%20in%20patients%20with%20severe%20acne:%20a%20pilot%20study&rft.jtitle=Journal%20of%20the%20European%20Academy%20of%20Dermatology%20and%20Venereology&rft.au=Ismailogullari,%20S&rft.date=2012-06&rft.volume=26&rft.issue=6&rft.spage=778&rft.epage=781&rft.pages=778-781&rft.issn=0926-9959&rft.eissn=1468-3083&rft_id=info:doi/10.1111/j.1468-3083.2011.04095.x&rft_dat=%3Cproquest_cross%3E1016672877%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1016672877&rft_id=info:pmid/21545544&rfr_iscdi=true |