Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrat...

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Veröffentlicht in:	Nature (London) 2012-05, Vol.485 (7399), p.465-470
Hauptverfasser:	Zeigerer, Anja, Gilleron, Jerome, Bogorad, Roman L., Marsico, Giovanni, Nonaka, Hidenori, Seifert, Sarah, Epstein-Barash, Hila, Kuchimanchi, Satya, Peng, Chang Geng, Ruda, Vera M., Conte-Zerial, Perla Del, Hengstler, Jan G., Kalaidzidis, Yannis, Koteliansky, Victor, Zerial, Marino
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/607/1164 631/80/642/1776 Animals Biosynthesis Cell cycle Cell hybridization Cell Polarity Cells, Cultured Endocytosis Endosomes - metabolism Gene Knockdown Techniques Genetic aspects Hepatocytes - cytology Hepatocytes - metabolism Humanities and Social Sciences Isoenzymes - biosynthesis Isoenzymes - deficiency Isoenzymes - genetics Isoenzymes - metabolism Lipoproteins, LDL - metabolism Liver Liver - cytology Liver - enzymology Liver - metabolism Liver cells Lysosomes Lysosomes - metabolism Mathematical models Mice multidisciplinary Multivesicular Bodies - metabolism Ordinary differential equations Organ Specificity Properties Protein Biosynthesis Proteins rab5 GTP-Binding Proteins - biosynthesis rab5 GTP-Binding Proteins - deficiency rab5 GTP-Binding Proteins - genetics rab5 GTP-Binding Proteins - metabolism RNA Interference RNA, Messenger - analysis RNA, Messenger - genetics Science Science (multidisciplinary) Time Factors Vesicular Transport Proteins - metabolism
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