Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances
We compared the structures and rheology of xanthan–galactomannan (X:G) hydrogels with the addition of curcumin in microemulsion (X:GMC) and ethanol (X:GEC). X:GMC hydrogels have gel characteristics and exhibited a significantly higher elastic response than the X:GEC and X:G hydrogels at room tempera...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 2012-07, Vol.101 (7), p.2457-2467 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2467 |
|---|---|
| container_issue | 7 |
| container_start_page | 2457 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 101 |
| creator | Koop, Heidegrid S. Da-lozzo, Eneida J. de Freitas, Rilton A. Franco, Célia R.C. Mitchell, David A. Silveira, Joana L.M. |
| description | We compared the structures and rheology of xanthan–galactomannan (X:G) hydrogels with the addition of curcumin in microemulsion (X:GMC) and ethanol (X:GEC). X:GMC hydrogels have gel characteristics and exhibited a significantly higher elastic response than the X:GEC and X:G hydrogels at room temperature, but after heating, an increase in the elastic modulus was observed for the last two systems. The visualization of the hydrogel microstructures by cryo-scanning electronic microscopy revealed pores within the lamellar structure only for X:GMC. In vitro skin permeation tests showed a more pronounced lag time for X:GMC; however, a more efficient permeation from X:GMC than from X:GEC. This study demonstrates that the X:G system is an alternative to traditional gels for the topical applications of hydrophobic drugs. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association. |
| doi_str_mv | 10.1002/jps.23178 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1016669430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354915315483</els_id><sourcerecordid>1016669430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4658-f6000fb1d73b1104322fb04b448a1694cd459522619de7016806995a185d884a3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EotvCgRdAkRBSOaS1HdtJjmgFW2BVoC0CcbEmttN4ycbBTijLiXfgDXkSzGZbJAQnS57v_2fmH4QeEHxEMKbHqz4c0YzkxS00I5ziVGCS30azWKNpxlm5h_ZDWGGMBeb8LtqjNH7mQsyQPmuMa92lVdAm8wY8qMF4-w0G67rE1QkkH6AbGuh-fv-xgDaW3Rq6DrrkZKO9uzRtsnSgjU6u7NAkS9u7vrGtVcn5WIUBOmXCPXSnhjaY-7v3AL17_uxifpIuXy9ezJ8uU8UEL9JaxAnriug8qwjBLKO0rjCrGCuAiJIpzXjJKRWk1CbHRBRYlCUHUnBdFAyyA3Q4-fbefR5NGOTaBmXaFjrjxiBJ1IholOGIPvoLXbnRd3E6STjJs9hnSz2ZKOVdCN7Usvd2DX4TreTv6GWMXm6jj-zDneNYrY2-Ia-zjsDjHQAhpl37mI0Nfzix3YhH7njirmxrNv_vKF--Ob9unU4KGwbz9UYB_pMUeZZz-f50IV8tWPn27PRCfox8NvEmHuOLNV4GZU28lLbeqEFqZ_-x4C_LFLqd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517395230</pqid></control><display><type>article</type><title>Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Koop, Heidegrid S. ; Da-lozzo, Eneida J. ; de Freitas, Rilton A. ; Franco, Célia R.C. ; Mitchell, David A. ; Silveira, Joana L.M.</creator><creatorcontrib>Koop, Heidegrid S. ; Da-lozzo, Eneida J. ; de Freitas, Rilton A. ; Franco, Célia R.C. ; Mitchell, David A. ; Silveira, Joana L.M.</creatorcontrib><description>We compared the structures and rheology of xanthan–galactomannan (X:G) hydrogels with the addition of curcumin in microemulsion (X:GMC) and ethanol (X:GEC). X:GMC hydrogels have gel characteristics and exhibited a significantly higher elastic response than the X:GEC and X:G hydrogels at room temperature, but after heating, an increase in the elastic modulus was observed for the last two systems. The visualization of the hydrogel microstructures by cryo-scanning electronic microscopy revealed pores within the lamellar structure only for X:GMC. In vitro skin permeation tests showed a more pronounced lag time for X:GMC; however, a more efficient permeation from X:GMC than from X:GEC. This study demonstrates that the X:G system is an alternative to traditional gels for the topical applications of hydrophobic drugs. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.23178</identifier><identifier>PMID: 22549766</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Hoboken: Elsevier Inc</publisher><subject>Administration, Cutaneous ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacokinetics ; Biological and medical sciences ; cryo-scanning electronic microscopy ; Curcumin - administration & dosage ; Curcumin - pharmacokinetics ; Drug Carriers - chemistry ; drug delivery system ; General pharmacology ; hydrogel ; Hydrogels - chemistry ; interaction ; Mannans - chemistry ; Medical sciences ; microemulsions ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; polymeric biomaterial ; Polysaccharides, Bacterial - chemistry ; Rheology ; Skin - metabolism ; Skin Absorption ; Swine ; transdermal drug delivery</subject><ispartof>Journal of pharmaceutical sciences, 2012-07, Vol.101 (7), p.2457-2467</ispartof><rights>2012 Wiley Periodicals, Inc.</rights><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4658-f6000fb1d73b1104322fb04b448a1694cd459522619de7016806995a185d884a3</citedby><cites>FETCH-LOGICAL-c4658-f6000fb1d73b1104322fb04b448a1694cd459522619de7016806995a185d884a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.23178$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.23178$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26016805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22549766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koop, Heidegrid S.</creatorcontrib><creatorcontrib>Da-lozzo, Eneida J.</creatorcontrib><creatorcontrib>de Freitas, Rilton A.</creatorcontrib><creatorcontrib>Franco, Célia R.C.</creatorcontrib><creatorcontrib>Mitchell, David A.</creatorcontrib><creatorcontrib>Silveira, Joana L.M.</creatorcontrib><title>Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>We compared the structures and rheology of xanthan–galactomannan (X:G) hydrogels with the addition of curcumin in microemulsion (X:GMC) and ethanol (X:GEC). X:GMC hydrogels have gel characteristics and exhibited a significantly higher elastic response than the X:GEC and X:G hydrogels at room temperature, but after heating, an increase in the elastic modulus was observed for the last two systems. The visualization of the hydrogel microstructures by cryo-scanning electronic microscopy revealed pores within the lamellar structure only for X:GMC. In vitro skin permeation tests showed a more pronounced lag time for X:GMC; however, a more efficient permeation from X:GMC than from X:GEC. This study demonstrates that the X:G system is an alternative to traditional gels for the topical applications of hydrophobic drugs. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>cryo-scanning electronic microscopy</subject><subject>Curcumin - administration & dosage</subject><subject>Curcumin - pharmacokinetics</subject><subject>Drug Carriers - chemistry</subject><subject>drug delivery system</subject><subject>General pharmacology</subject><subject>hydrogel</subject><subject>Hydrogels - chemistry</subject><subject>interaction</subject><subject>Mannans - chemistry</subject><subject>Medical sciences</subject><subject>microemulsions</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>polymeric biomaterial</subject><subject>Polysaccharides, Bacterial - chemistry</subject><subject>Rheology</subject><subject>Skin - metabolism</subject><subject>Skin Absorption</subject><subject>Swine</subject><subject>transdermal drug delivery</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EotvCgRdAkRBSOaS1HdtJjmgFW2BVoC0CcbEmttN4ycbBTijLiXfgDXkSzGZbJAQnS57v_2fmH4QeEHxEMKbHqz4c0YzkxS00I5ziVGCS30azWKNpxlm5h_ZDWGGMBeb8LtqjNH7mQsyQPmuMa92lVdAm8wY8qMF4-w0G67rE1QkkH6AbGuh-fv-xgDaW3Rq6DrrkZKO9uzRtsnSgjU6u7NAkS9u7vrGtVcn5WIUBOmXCPXSnhjaY-7v3AL17_uxifpIuXy9ezJ8uU8UEL9JaxAnriug8qwjBLKO0rjCrGCuAiJIpzXjJKRWk1CbHRBRYlCUHUnBdFAyyA3Q4-fbefR5NGOTaBmXaFjrjxiBJ1IholOGIPvoLXbnRd3E6STjJs9hnSz2ZKOVdCN7Usvd2DX4TreTv6GWMXm6jj-zDneNYrY2-Ia-zjsDjHQAhpl37mI0Nfzix3YhH7njirmxrNv_vKF--Ob9unU4KGwbz9UYB_pMUeZZz-f50IV8tWPn27PRCfox8NvEmHuOLNV4GZU28lLbeqEFqZ_-x4C_LFLqd</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Koop, Heidegrid S.</creator><creator>Da-lozzo, Eneida J.</creator><creator>de Freitas, Rilton A.</creator><creator>Franco, Célia R.C.</creator><creator>Mitchell, David A.</creator><creator>Silveira, Joana L.M.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances</title><author>Koop, Heidegrid S. ; Da-lozzo, Eneida J. ; de Freitas, Rilton A. ; Franco, Célia R.C. ; Mitchell, David A. ; Silveira, Joana L.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4658-f6000fb1d73b1104322fb04b448a1694cd459522619de7016806995a185d884a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>cryo-scanning electronic microscopy</topic><topic>Curcumin - administration & dosage</topic><topic>Curcumin - pharmacokinetics</topic><topic>Drug Carriers - chemistry</topic><topic>drug delivery system</topic><topic>General pharmacology</topic><topic>hydrogel</topic><topic>Hydrogels - chemistry</topic><topic>interaction</topic><topic>Mannans - chemistry</topic><topic>Medical sciences</topic><topic>microemulsions</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>polymeric biomaterial</topic><topic>Polysaccharides, Bacterial - chemistry</topic><topic>Rheology</topic><topic>Skin - metabolism</topic><topic>Skin Absorption</topic><topic>Swine</topic><topic>transdermal drug delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koop, Heidegrid S.</creatorcontrib><creatorcontrib>Da-lozzo, Eneida J.</creatorcontrib><creatorcontrib>de Freitas, Rilton A.</creatorcontrib><creatorcontrib>Franco, Célia R.C.</creatorcontrib><creatorcontrib>Mitchell, David A.</creatorcontrib><creatorcontrib>Silveira, Joana L.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koop, Heidegrid S.</au><au>Da-lozzo, Eneida J.</au><au>de Freitas, Rilton A.</au><au>Franco, Célia R.C.</au><au>Mitchell, David A.</au><au>Silveira, Joana L.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>2012-07</date><risdate>2012</risdate><volume>101</volume><issue>7</issue><spage>2457</spage><epage>2467</epage><pages>2457-2467</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>We compared the structures and rheology of xanthan–galactomannan (X:G) hydrogels with the addition of curcumin in microemulsion (X:GMC) and ethanol (X:GEC). X:GMC hydrogels have gel characteristics and exhibited a significantly higher elastic response than the X:GEC and X:G hydrogels at room temperature, but after heating, an increase in the elastic modulus was observed for the last two systems. The visualization of the hydrogel microstructures by cryo-scanning electronic microscopy revealed pores within the lamellar structure only for X:GMC. In vitro skin permeation tests showed a more pronounced lag time for X:GMC; however, a more efficient permeation from X:GMC than from X:GEC. This study demonstrates that the X:G system is an alternative to traditional gels for the topical applications of hydrophobic drugs. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.</abstract><cop>Hoboken</cop><pub>Elsevier Inc</pub><pmid>22549766</pmid><doi>10.1002/jps.23178</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 2012-07, Vol.101 (7), p.2457-2467 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1016669430 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Administration, Cutaneous Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences cryo-scanning electronic microscopy Curcumin - administration & dosage Curcumin - pharmacokinetics Drug Carriers - chemistry drug delivery system General pharmacology hydrogel Hydrogels - chemistry interaction Mannans - chemistry Medical sciences microemulsions Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polymeric biomaterial Polysaccharides, Bacterial - chemistry Rheology Skin - metabolism Skin Absorption Swine transdermal drug delivery |
| title | Rheological Characterization of a Xanthan–Galactomannan Hydrogel Loaded with Lipophilic Substances |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T19%3A05%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rheological%20Characterization%20of%20a%20Xanthan%E2%80%93Galactomannan%20Hydrogel%20Loaded%20with%20Lipophilic%20Substances&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Koop,%20Heidegrid%20S.&rft.date=2012-07&rft.volume=101&rft.issue=7&rft.spage=2457&rft.epage=2467&rft.pages=2457-2467&rft.issn=0022-3549&rft.eissn=1520-6017&rft.coden=JPMSAE&rft_id=info:doi/10.1002/jps.23178&rft_dat=%3Cproquest_cross%3E1016669430%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1517395230&rft_id=info:pmid/22549766&rft_els_id=S0022354915315483&rfr_iscdi=true |