Diagnostic Accuracy of a Specific Cytokine Pattern in Hemophagocytic Lymphohistiocytosis in Children

Objective The study goal was to determine the diagnostic accuracy of a specific cytokine pattern including interferon-gamma (IFN-γ), interleukin (IL)-10, and IL-6 for hemophagocytic lymphohistiocytosis (HLH) in febrile children. Study design In this prospective study, 756 patients with fever admitte...

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Veröffentlicht in:	The Journal of pediatrics 2012-06, Vol.160 (6), p.984-990.e1
Hauptverfasser:	Xu, Xiao-Jun, MD, Tang, Yong-Min, MD, Song, Hua, MD, Yang, Shi-Long, MD, Xu, Wei-Qun, MD, PhD, Zhao, Ning, MD, Shi, Shu-Wen, MD, Shen, He-Ping, MD, Mao, Jun-Qing, MD, Zhang, Ling-Yan, MD, Pan, Bin-Hua, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Biomarkers - blood blood serum Child Child, Preschool children Cytokines - blood Diagnosis, Differential Female fever Follow-Up Studies General aspects Humans Infant Infant, Newborn interferon-gamma Interferon-gamma - blood interleukin-10 Interleukin-10 - blood interleukin-2 interleukin-4 interleukin-6 Interleukin-6 - blood Lymphohistiocytosis, Hemophagocytic - blood Lymphohistiocytosis, Hemophagocytic - diagnosis Male Medical sciences patients Pediatrics Prospective Studies Reproducibility of Results tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - blood
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