A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy
Castleman disease (CD) is a rare lymphoproliferative disorder. Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standa...
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| Veröffentlicht in: | Japanese journal of radiology 2012-05, Vol.30 (4), p.349-353 |
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| creator | Tomita, Natsuo Kodaira, Takeshi Tomoda, Takuya Nakajima, Kosei Murao, Takayuki Kitamura, Kunio |
| description | Castleman disease (CD) is a rare lymphoproliferative disorder. Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standard therapy for the unicentric form, no consensus has been reached concerning the standard treatment for multicentric CD. We report here a case of cervical multicentric CD treated with intensity-modulated radiation therapy (IMRT), using helical tomotherapy to minimize xerostomia in comparison with conventional radiotherapy. A 29-year-old woman complained of neck swelling. Computed tomography showed lymphadenopathy in both sides of the neck. The patient was diagnosed with the plasma cell subtype of CD on biopsy. After initial treatment with prednisone, IMRT was planned to avoid normal structures, for example the parotid gland. The cervical lymphadenopathy shrank gradually during IMRT with 44 Gy in 22 fractions. Four years and 3 months after IMRT, regrowth of cervical lymph nodes has not been detected. The parotid function improved dramatically on quantitative salivary scintigraphy between 3 and 12 months after IMRT. Radiotherapy could be an option for multicentric CD, and IMRT is an effective means of minimizing xerostomia in head and neck lesions. |
| doi_str_mv | 10.1007/s11604-012-0052-0 |
| format | Article |
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Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standard therapy for the unicentric form, no consensus has been reached concerning the standard treatment for multicentric CD. We report here a case of cervical multicentric CD treated with intensity-modulated radiation therapy (IMRT), using helical tomotherapy to minimize xerostomia in comparison with conventional radiotherapy. A 29-year-old woman complained of neck swelling. Computed tomography showed lymphadenopathy in both sides of the neck. The patient was diagnosed with the plasma cell subtype of CD on biopsy. After initial treatment with prednisone, IMRT was planned to avoid normal structures, for example the parotid gland. The cervical lymphadenopathy shrank gradually during IMRT with 44 Gy in 22 fractions. Four years and 3 months after IMRT, regrowth of cervical lymph nodes has not been detected. The parotid function improved dramatically on quantitative salivary scintigraphy between 3 and 12 months after IMRT. Radiotherapy could be an option for multicentric CD, and IMRT is an effective means of minimizing xerostomia in head and neck lesions.</description><identifier>ISSN: 1867-1071</identifier><identifier>EISSN: 1867-108X</identifier><identifier>DOI: 10.1007/s11604-012-0052-0</identifier><identifier>PMID: 22258813</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Adult ; Case Report ; Castleman Disease - diagnostic imaging ; Castleman Disease - radiotherapy ; Female ; Humans ; Imaging ; Medicine ; Medicine & Public Health ; Neck ; Nuclear Medicine ; Radiology ; Radiotherapy ; Radiotherapy, Intensity-Modulated - methods ; Tomography, Spiral Computed ; Xerostomia - prevention & control</subject><ispartof>Japanese journal of radiology, 2012-05, Vol.30 (4), p.349-353</ispartof><rights>Japan Radiological Society 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c887f98059d76080b0ac89086f07ba827c5361d07e65f3bdde7ec8b0ef1e9df63</citedby><cites>FETCH-LOGICAL-c396t-c887f98059d76080b0ac89086f07ba827c5361d07e65f3bdde7ec8b0ef1e9df63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11604-012-0052-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11604-012-0052-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22258813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomita, Natsuo</creatorcontrib><creatorcontrib>Kodaira, Takeshi</creatorcontrib><creatorcontrib>Tomoda, Takuya</creatorcontrib><creatorcontrib>Nakajima, Kosei</creatorcontrib><creatorcontrib>Murao, Takayuki</creatorcontrib><creatorcontrib>Kitamura, Kunio</creatorcontrib><title>A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy</title><title>Japanese journal of radiology</title><addtitle>Jpn J Radiol</addtitle><addtitle>Jpn J Radiol</addtitle><description>Castleman disease (CD) is a rare lymphoproliferative disorder. Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standard therapy for the unicentric form, no consensus has been reached concerning the standard treatment for multicentric CD. We report here a case of cervical multicentric CD treated with intensity-modulated radiation therapy (IMRT), using helical tomotherapy to minimize xerostomia in comparison with conventional radiotherapy. A 29-year-old woman complained of neck swelling. Computed tomography showed lymphadenopathy in both sides of the neck. The patient was diagnosed with the plasma cell subtype of CD on biopsy. After initial treatment with prednisone, IMRT was planned to avoid normal structures, for example the parotid gland. The cervical lymphadenopathy shrank gradually during IMRT with 44 Gy in 22 fractions. Four years and 3 months after IMRT, regrowth of cervical lymph nodes has not been detected. The parotid function improved dramatically on quantitative salivary scintigraphy between 3 and 12 months after IMRT. Radiotherapy could be an option for multicentric CD, and IMRT is an effective means of minimizing xerostomia in head and neck lesions.</description><subject>Adult</subject><subject>Case Report</subject><subject>Castleman Disease - diagnostic imaging</subject><subject>Castleman Disease - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neck</subject><subject>Nuclear Medicine</subject><subject>Radiology</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Tomography, Spiral Computed</subject><subject>Xerostomia - prevention & control</subject><issn>1867-1071</issn><issn>1867-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtr3DAURkVJadK0P6CbIuimG6dXtvXwMgx9QSCbFrozsnSdUbCliSQnzKa_PZpHQyhkIwm-c78rOIR8YHDBAOSXxJiAtgJWVwC8HK_IGVNCVgzUn5Ont2Sn5G1KtwCibdr2DTmt65orxZoz8veSGp2QhpEajPfO6InOy5SdQZ-jM3SlU55w1p5al3CH5og6o6UPLq-p8xl9cnlbzcEu0z6I2jqdXfA0rzHqzZYuyfkbusZp35_DHI7JO_J61FPC98f7nPz-9vXX6kd1df395-ryqjJNJ3JllJJjp4B3VgpQMIA2qgMlRpCDVrU0vBHMgkTBx2awFiUaNQCODDs7iuacfD70bmK4WzDlfnbJ4DRpj2FJPQPGJRecNwX99B96G5boy-_2VCNa3qlCsQNlYkgp4thvopt13Bao38npD3L6IqffyemhzHw8Ni_DjPZp4p-NAtQHIJXI32B8vvql1keXZJwj</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Tomita, Natsuo</creator><creator>Kodaira, Takeshi</creator><creator>Tomoda, Takuya</creator><creator>Nakajima, Kosei</creator><creator>Murao, Takayuki</creator><creator>Kitamura, Kunio</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy</title><author>Tomita, Natsuo ; Kodaira, Takeshi ; Tomoda, Takuya ; Nakajima, Kosei ; Murao, Takayuki ; Kitamura, Kunio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c887f98059d76080b0ac89086f07ba827c5361d07e65f3bdde7ec8b0ef1e9df63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Case Report</topic><topic>Castleman Disease - diagnostic imaging</topic><topic>Castleman Disease - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neck</topic><topic>Nuclear Medicine</topic><topic>Radiology</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Tomography, Spiral Computed</topic><topic>Xerostomia - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Natsuo</creatorcontrib><creatorcontrib>Kodaira, Takeshi</creatorcontrib><creatorcontrib>Tomoda, Takuya</creatorcontrib><creatorcontrib>Nakajima, Kosei</creatorcontrib><creatorcontrib>Murao, Takayuki</creatorcontrib><creatorcontrib>Kitamura, Kunio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Natsuo</au><au>Kodaira, Takeshi</au><au>Tomoda, Takuya</au><au>Nakajima, Kosei</au><au>Murao, Takayuki</au><au>Kitamura, Kunio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy</atitle><jtitle>Japanese journal of radiology</jtitle><stitle>Jpn J Radiol</stitle><addtitle>Jpn J Radiol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>30</volume><issue>4</issue><spage>349</spage><epage>353</epage><pages>349-353</pages><issn>1867-1071</issn><eissn>1867-108X</eissn><abstract>Castleman disease (CD) is a rare lymphoproliferative disorder. Two clinical entities are described: a unicentric form with disease confined to a single lymph node region and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. Although surgery is regarded as standard therapy for the unicentric form, no consensus has been reached concerning the standard treatment for multicentric CD. We report here a case of cervical multicentric CD treated with intensity-modulated radiation therapy (IMRT), using helical tomotherapy to minimize xerostomia in comparison with conventional radiotherapy. A 29-year-old woman complained of neck swelling. Computed tomography showed lymphadenopathy in both sides of the neck. The patient was diagnosed with the plasma cell subtype of CD on biopsy. After initial treatment with prednisone, IMRT was planned to avoid normal structures, for example the parotid gland. The cervical lymphadenopathy shrank gradually during IMRT with 44 Gy in 22 fractions. Four years and 3 months after IMRT, regrowth of cervical lymph nodes has not been detected. The parotid function improved dramatically on quantitative salivary scintigraphy between 3 and 12 months after IMRT. Radiotherapy could be an option for multicentric CD, and IMRT is an effective means of minimizing xerostomia in head and neck lesions.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>22258813</pmid><doi>10.1007/s11604-012-0052-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Japanese journal of radiology, 2012-05, Vol.30 (4), p.349-353 |
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| subjects | Adult Case Report Castleman Disease - diagnostic imaging Castleman Disease - radiotherapy Female Humans Imaging Medicine Medicine & Public Health Neck Nuclear Medicine Radiology Radiotherapy Radiotherapy, Intensity-Modulated - methods Tomography, Spiral Computed Xerostomia - prevention & control |
| title | A case of cervical multicentric Castleman disease treated with intensity-modulated radiation therapy using helical tomotherapy |
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