The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

Focal adhesion kinase (FAK) is upregulated in several epithelial tumours and there has been considerable interest in developing small molecule kinase inhibitors of FAK. However, FAK also has important adaptor functions within the cell, integrating signals from both integrins and growth factors. To i...

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Veröffentlicht in:	International journal of cancer 2012-07, Vol.131 (2), p.287-297
Hauptverfasser:	Serrels, Alan, McLeod, Kenneth, Canel, Marta, Kinnaird, Andrew, Graham, Kathryn, Frame, Margaret C, Brunton, Valerie G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cancer Cancer therapies Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Movement Cell Polarity Cell Proliferation - drug effects Dasatinib Dermatology FAK Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - deficiency Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Indoles - pharmacology Kinases Medical research Medical sciences Mice Mice, Transgenic proliferation Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Signal Transduction Src src-Family Kinases - metabolism Sulfonamides - pharmacology Thiazoles - pharmacology Tumors Tumors of the skin and soft tissue. Premalignant lesions tumour cell migration
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