Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype
Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41‐year‐old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0...
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Veröffentlicht in: | Pathology international 2012-06, Vol.62 (6), p.429-432 |
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description | Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41‐year‐old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well‐circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal‐like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal‐like immunophenotype. |
doi_str_mv | 10.1111/j.1440-1827.2012.02810.x |
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A case of MCA is reported in a 41‐year‐old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well‐circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal‐like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal‐like immunophenotype.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/j.1440-1827.2012.02810.x</identifier><identifier>PMID: 22612513</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Biomarkers, Tumor - metabolism ; breast ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma, Basal Cell - metabolism ; Carcinoma, Basal Cell - secondary ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Cystadenocarcinoma, Mucinous - metabolism ; Cystadenocarcinoma, Mucinous - secondary ; Disease-Free Survival ; Female ; Humans ; immunohistochemisty ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Mastectomy ; mucinous carcinoma ; mucinous cystadenocarcinoma ; Neoplasm Staging ; Neoplasms, Multiple Primary</subject><ispartof>Pathology international, 2012-06, Vol.62 (6), p.429-432</ispartof><rights>2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd</rights><rights>2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-7e52ef500e799bd61a179536e7582a8af0fd315b313af0bfcaae0f08c9ccbea73</citedby><cites>FETCH-LOGICAL-c3930-7e52ef500e799bd61a179536e7582a8af0fd315b313af0bfcaae0f08c9ccbea73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1827.2012.02810.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1827.2012.02810.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22612513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Yunte</creatorcontrib><creatorcontrib>Xue, Debin</creatorcontrib><creatorcontrib>Wang, Xiaoyan</creatorcontrib><creatorcontrib>Xu, Sanpeng</creatorcontrib><creatorcontrib>Ao, Qilin</creatorcontrib><creatorcontrib>Hu, Zhiyong</creatorcontrib><creatorcontrib>Wang, Guoping</creatorcontrib><title>Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41‐year‐old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well‐circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal‐like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal‐like immunophenotype.</description><subject>Adult</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>breast</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Basal Cell - metabolism</subject><subject>Carcinoma, Basal Cell - secondary</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Cystadenocarcinoma, Mucinous - metabolism</subject><subject>Cystadenocarcinoma, Mucinous - secondary</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>immunohistochemisty</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Mastectomy</subject><subject>mucinous carcinoma</subject><subject>mucinous cystadenocarcinoma</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwC8hLNgl-xHksWKCKR6UWWMDacpyxmpJHiRO12fEJfCNfgkNL18xmrjz3zsgHIUyJT11dr3waBMSjMYt8RijzCYvdbHuExofBsdOcEU8EIR-hM2tXhNCIh-QUjRgLKROUj9Fi0em8qjuLdW9blUFVa9UMT6XCtcHtEnDagLIt3uTtEiucKquK78-vIn8HnJdlV9XrpYu1_RrO0YlRhYWLfZ-gt_u71-mjN39-mE1v557mCSdeBIKBEYRAlCRpFlJFo0TwECIRMxUrQ0zGqUg55U6nRisFxJBYJ1qnoCI-QVe7veum_ujAtrLMrYaiUBW4v0hKqAgiwjhz1nhn1U1tbQNGrpu8VE3vTHKAKVdyYCYHZnKAKX9hyq2LXu6vdGkJ2SH4R88ZbnaGTV5A_-_F8mX2NCj-AwDMhLY</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Deng, Yunte</creator><creator>Xue, Debin</creator><creator>Wang, Xiaoyan</creator><creator>Xu, Sanpeng</creator><creator>Ao, Qilin</creator><creator>Hu, Zhiyong</creator><creator>Wang, Guoping</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype</title><author>Deng, Yunte ; Xue, Debin ; Wang, Xiaoyan ; Xu, Sanpeng ; Ao, Qilin ; Hu, Zhiyong ; Wang, Guoping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-7e52ef500e799bd61a179536e7582a8af0fd315b313af0bfcaae0f08c9ccbea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>breast</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Basal Cell - metabolism</topic><topic>Carcinoma, Basal Cell - secondary</topic><topic>Carcinoma, Intraductal, Noninfiltrating - pathology</topic><topic>Cystadenocarcinoma, Mucinous - metabolism</topic><topic>Cystadenocarcinoma, Mucinous - secondary</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>immunohistochemisty</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Mastectomy</topic><topic>mucinous carcinoma</topic><topic>mucinous cystadenocarcinoma</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Yunte</creatorcontrib><creatorcontrib>Xue, Debin</creatorcontrib><creatorcontrib>Wang, Xiaoyan</creatorcontrib><creatorcontrib>Xu, Sanpeng</creatorcontrib><creatorcontrib>Ao, Qilin</creatorcontrib><creatorcontrib>Hu, Zhiyong</creatorcontrib><creatorcontrib>Wang, Guoping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Yunte</au><au>Xue, Debin</au><au>Wang, Xiaoyan</au><au>Xu, Sanpeng</au><au>Ao, Qilin</au><au>Hu, Zhiyong</au><au>Wang, Guoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2012-06</date><risdate>2012</risdate><volume>62</volume><issue>6</issue><spage>429</spage><epage>432</epage><pages>429-432</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41‐year‐old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well‐circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal‐like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal‐like immunophenotype.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22612513</pmid><doi>10.1111/j.1440-1827.2012.02810.x</doi><tpages>4</tpages></addata></record> |
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subjects | Adult Biomarkers, Tumor - metabolism breast Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - secondary Carcinoma, Intraductal, Noninfiltrating - pathology Cystadenocarcinoma, Mucinous - metabolism Cystadenocarcinoma, Mucinous - secondary Disease-Free Survival Female Humans immunohistochemisty Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis Mastectomy mucinous carcinoma mucinous cystadenocarcinoma Neoplasm Staging Neoplasms, Multiple Primary |
title | Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype |
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