Correlations of TOP2A gene aberrations and expression of topoisomerase IIα protein and TOP2A mRNA expression in primary breast cancer: A retrospective study of 86 cases using fluorescence in situ hybridization and immunohistochemistry

Our aim in this study was to assess the status of TOP2A gene aberrations (no change/amplification or deletion) and its correlations with topoisomerase IIα (Topo IIα) protein and TOP2A mRNA expression, respectively. TOP2A amplification, Topo IIα protein expression and TOP2A mRNA expression were asses...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology international 2012-06, Vol.62 (6), p.391-399
Hauptverfasser:	Meng, Hui, Chen, Renyin, Li, Wencai, Xu, Li, Xu, Lina
Format:	Artikel
Sprache:	eng
Schlagworte:	aneusomy Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - mortality Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Lobular - genetics Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Carcinoma, Lobular - pathology China - epidemiology DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female fluorescence in situ hybridization Gene Amplification Gene Deletion Gene Expression Regulation, Neoplastic Humans immunohistochemistry Immunohistochemistry - methods In Situ Hybridization, Fluorescence - methods Middle Aged Poly-ADP-Ribose Binding Proteins Retrospective Studies RNA, Messenger - metabolism Survival Rate topoisomerase IIα
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!