Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study
Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the Hear...
Gespeichert in:
| Veröffentlicht in: | European journal of preventive cardiology 2012-06, Vol.19 (3), p.558-564 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 564 |
|---|---|
| container_issue | 3 |
| container_start_page | 558 |
| container_title | European journal of preventive cardiology |
| container_volume | 19 |
| creator | Diederichsen, Axel CP Sand, Niels Peter Nørgaard, Bjarne Lambrechtsen, Jess Jensen, Jesper Møller Munkholm, Henrik Aziz, Ahmed Gerke, Oke Egstrup, Kenneth Larsen, Mogens Lytken Petersen, Henrik Høilund-Carlsen, Poul F Mickley, Hans |
| description | Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as |
| doi_str_mv | 10.1177/1741826711409172 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1015467526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1741826711409172</sage_id><sourcerecordid>1015467526</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-d400f1b6e664a50b536ee24857066224614de5950b4718afe6a471a02fcc87b83</originalsourceid><addsrcrecordid>eNp1UE1LAzEUDKLYUnv3JDl6WU2y-ao3adUKBcGP85JN3tqt-1GTXaT_3tTWHgRzeRNm3vBmEDqn5IpSpa6p4lQzqSjlZEIVO0JDRrhKuNb0-IBVOkDjEFYkPkkY0_oUDRgVTFDGh2g5K4P1sDaN3eAcui-ABtvWt43xG2x8B3FYU9myr3GIBGDTODyHSL38fMsG16VzFSTmHRyemQbCDe6WsIXPZfjAoevd5gydFKYKMN7PEXq7v3udzpPF08Pj9HaR2FRNusRxQgqaS5CSG0FykUoAxrVQRErGuKTcgZhEhiuqTQHSRGAIK6zVKtfpCF3ufNe-_ewhdFkdE0JVxbvaPmSUUMGlEkxGKdlJrW9D8FBka1_WMXcUZduKs78Vx5WLvXuf1-AOC7-FRkGyE4TYRrZqe9_EtP8bfgM05YJC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1015467526</pqid></control><display><type>article</type><title>Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study</title><source>SAGE Complete A-Z List</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Diederichsen, Axel CP ; Sand, Niels Peter ; Nørgaard, Bjarne ; Lambrechtsen, Jess ; Jensen, Jesper Møller ; Munkholm, Henrik ; Aziz, Ahmed ; Gerke, Oke ; Egstrup, Kenneth ; Larsen, Mogens Lytken ; Petersen, Henrik ; Høilund-Carlsen, Poul F ; Mickley, Hans</creator><creatorcontrib>Diederichsen, Axel CP ; Sand, Niels Peter ; Nørgaard, Bjarne ; Lambrechtsen, Jess ; Jensen, Jesper Møller ; Munkholm, Henrik ; Aziz, Ahmed ; Gerke, Oke ; Egstrup, Kenneth ; Larsen, Mogens Lytken ; Petersen, Henrik ; Høilund-Carlsen, Poul F ; Mickley, Hans</creatorcontrib><description>Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as <5%. The CAC score was calculated from a non-contrast enhanced cardiac-CT scan and given in Agatston U. Results: A total of 1257 (69%) of the invited subjects were interested in the screening. Due to previous cardiovascular disease or diabetes mellitus, 101 were excluded. Of the remaining 1156, 47% were men and 53% women; one half were 50 years old and the other half 60 years old. A low HeartScore was found in 901 of which 334 (37%) had CAC. A high HeartScore was recorded in 251 of which 80 (32%) did not have any CAC. High HeartScores and CAC were significantly more common in males than females. Conclusions: CAC is common in healthy middle-aged Danes with a low HeartScore, and, on the contrary, high-risk subjects very frequently do not have CAC. The therapeutic and prognostic implications of these observations remain to be clarified.</description><identifier>ISSN: 2047-4873</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1177/1741826711409172</identifier><identifier>PMID: 21525124</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Asymptomatic Diseases ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Denmark - epidemiology ; Disease Progression ; Female ; Humans ; Male ; Mass Screening - methods ; Middle Aged ; Multidetector Computed Tomography ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Prevalence ; Prognosis ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Time Factors ; Vascular Calcification - diagnostic imaging ; Vascular Calcification - mortality</subject><ispartof>European journal of preventive cardiology, 2012-06, Vol.19 (3), p.558-564</ispartof><rights>The European Society of Cardiology 2011 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-d400f1b6e664a50b536ee24857066224614de5950b4718afe6a471a02fcc87b83</citedby><cites>FETCH-LOGICAL-c379t-d400f1b6e664a50b536ee24857066224614de5950b4718afe6a471a02fcc87b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1741826711409172$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1741826711409172$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21800,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21525124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diederichsen, Axel CP</creatorcontrib><creatorcontrib>Sand, Niels Peter</creatorcontrib><creatorcontrib>Nørgaard, Bjarne</creatorcontrib><creatorcontrib>Lambrechtsen, Jess</creatorcontrib><creatorcontrib>Jensen, Jesper Møller</creatorcontrib><creatorcontrib>Munkholm, Henrik</creatorcontrib><creatorcontrib>Aziz, Ahmed</creatorcontrib><creatorcontrib>Gerke, Oke</creatorcontrib><creatorcontrib>Egstrup, Kenneth</creatorcontrib><creatorcontrib>Larsen, Mogens Lytken</creatorcontrib><creatorcontrib>Petersen, Henrik</creatorcontrib><creatorcontrib>Høilund-Carlsen, Poul F</creatorcontrib><creatorcontrib>Mickley, Hans</creatorcontrib><title>Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study</title><title>European journal of preventive cardiology</title><addtitle>Eur J Prev Cardiol</addtitle><description>Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as <5%. The CAC score was calculated from a non-contrast enhanced cardiac-CT scan and given in Agatston U. Results: A total of 1257 (69%) of the invited subjects were interested in the screening. Due to previous cardiovascular disease or diabetes mellitus, 101 were excluded. Of the remaining 1156, 47% were men and 53% women; one half were 50 years old and the other half 60 years old. A low HeartScore was found in 901 of which 334 (37%) had CAC. A high HeartScore was recorded in 251 of which 80 (32%) did not have any CAC. High HeartScores and CAC were significantly more common in males than females. Conclusions: CAC is common in healthy middle-aged Danes with a low HeartScore, and, on the contrary, high-risk subjects very frequently do not have CAC. The therapeutic and prognostic implications of these observations remain to be clarified.</description><subject>Asymptomatic Diseases</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Denmark - epidemiology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vascular Calcification - mortality</subject><issn>2047-4873</issn><issn>2047-4881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UE1LAzEUDKLYUnv3JDl6WU2y-ao3adUKBcGP85JN3tqt-1GTXaT_3tTWHgRzeRNm3vBmEDqn5IpSpa6p4lQzqSjlZEIVO0JDRrhKuNb0-IBVOkDjEFYkPkkY0_oUDRgVTFDGh2g5K4P1sDaN3eAcui-ABtvWt43xG2x8B3FYU9myr3GIBGDTODyHSL38fMsG16VzFSTmHRyemQbCDe6WsIXPZfjAoevd5gydFKYKMN7PEXq7v3udzpPF08Pj9HaR2FRNusRxQgqaS5CSG0FykUoAxrVQRErGuKTcgZhEhiuqTQHSRGAIK6zVKtfpCF3ufNe-_ewhdFkdE0JVxbvaPmSUUMGlEkxGKdlJrW9D8FBka1_WMXcUZduKs78Vx5WLvXuf1-AOC7-FRkGyE4TYRrZqe9_EtP8bfgM05YJC</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Diederichsen, Axel CP</creator><creator>Sand, Niels Peter</creator><creator>Nørgaard, Bjarne</creator><creator>Lambrechtsen, Jess</creator><creator>Jensen, Jesper Møller</creator><creator>Munkholm, Henrik</creator><creator>Aziz, Ahmed</creator><creator>Gerke, Oke</creator><creator>Egstrup, Kenneth</creator><creator>Larsen, Mogens Lytken</creator><creator>Petersen, Henrik</creator><creator>Høilund-Carlsen, Poul F</creator><creator>Mickley, Hans</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study</title><author>Diederichsen, Axel CP ; Sand, Niels Peter ; Nørgaard, Bjarne ; Lambrechtsen, Jess ; Jensen, Jesper Møller ; Munkholm, Henrik ; Aziz, Ahmed ; Gerke, Oke ; Egstrup, Kenneth ; Larsen, Mogens Lytken ; Petersen, Henrik ; Høilund-Carlsen, Poul F ; Mickley, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-d400f1b6e664a50b536ee24857066224614de5950b4718afe6a471a02fcc87b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Asymptomatic Diseases</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - mortality</topic><topic>Denmark - epidemiology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Reproducibility of Results</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vascular Calcification - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diederichsen, Axel CP</creatorcontrib><creatorcontrib>Sand, Niels Peter</creatorcontrib><creatorcontrib>Nørgaard, Bjarne</creatorcontrib><creatorcontrib>Lambrechtsen, Jess</creatorcontrib><creatorcontrib>Jensen, Jesper Møller</creatorcontrib><creatorcontrib>Munkholm, Henrik</creatorcontrib><creatorcontrib>Aziz, Ahmed</creatorcontrib><creatorcontrib>Gerke, Oke</creatorcontrib><creatorcontrib>Egstrup, Kenneth</creatorcontrib><creatorcontrib>Larsen, Mogens Lytken</creatorcontrib><creatorcontrib>Petersen, Henrik</creatorcontrib><creatorcontrib>Høilund-Carlsen, Poul F</creatorcontrib><creatorcontrib>Mickley, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of preventive cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diederichsen, Axel CP</au><au>Sand, Niels Peter</au><au>Nørgaard, Bjarne</au><au>Lambrechtsen, Jess</au><au>Jensen, Jesper Møller</au><au>Munkholm, Henrik</au><au>Aziz, Ahmed</au><au>Gerke, Oke</au><au>Egstrup, Kenneth</au><au>Larsen, Mogens Lytken</au><au>Petersen, Henrik</au><au>Høilund-Carlsen, Poul F</au><au>Mickley, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study</atitle><jtitle>European journal of preventive cardiology</jtitle><addtitle>Eur J Prev Cardiol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>19</volume><issue>3</issue><spage>558</spage><epage>564</epage><pages>558-564</pages><issn>2047-4873</issn><eissn>2047-4881</eissn><abstract>Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as <5%. The CAC score was calculated from a non-contrast enhanced cardiac-CT scan and given in Agatston U. Results: A total of 1257 (69%) of the invited subjects were interested in the screening. Due to previous cardiovascular disease or diabetes mellitus, 101 were excluded. Of the remaining 1156, 47% were men and 53% women; one half were 50 years old and the other half 60 years old. A low HeartScore was found in 901 of which 334 (37%) had CAC. A high HeartScore was recorded in 251 of which 80 (32%) did not have any CAC. High HeartScores and CAC were significantly more common in males than females. Conclusions: CAC is common in healthy middle-aged Danes with a low HeartScore, and, on the contrary, high-risk subjects very frequently do not have CAC. The therapeutic and prognostic implications of these observations remain to be clarified.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21525124</pmid><doi>10.1177/1741826711409172</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4873 |
| ispartof | European journal of preventive cardiology, 2012-06, Vol.19 (3), p.558-564 |
| issn | 2047-4873 2047-4881 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1015467526 |
| source | SAGE Complete A-Z List; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Asymptomatic Diseases Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Denmark - epidemiology Disease Progression Female Humans Male Mass Screening - methods Middle Aged Multidetector Computed Tomography Multivariate Analysis Odds Ratio Predictive Value of Tests Prevalence Prognosis Reproducibility of Results Risk Assessment Risk Factors Time Factors Vascular Calcification - diagnostic imaging Vascular Calcification - mortality |
| title | Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes: the DanRisk study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T14%3A31%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discrepancy%20between%20coronary%20artery%20calcium%20score%20and%20HeartScore%20in%20middle-aged%20Danes:%20the%20DanRisk%20study&rft.jtitle=European%20journal%20of%20preventive%20cardiology&rft.au=Diederichsen,%20Axel%20CP&rft.date=2012-06&rft.volume=19&rft.issue=3&rft.spage=558&rft.epage=564&rft.pages=558-564&rft.issn=2047-4873&rft.eissn=2047-4881&rft_id=info:doi/10.1177/1741826711409172&rft_dat=%3Cproquest_cross%3E1015467526%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1015467526&rft_id=info:pmid/21525124&rft_sage_id=10.1177_1741826711409172&rfr_iscdi=true |