The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland
XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation. In the present work the distribution of genotypes and frequency of alleles of the RAD51 G135C polymorphism, XR...
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| Veröffentlicht in: | European journal of gynaecological oncology 2012, Vol.33 (2), p.145-150 |
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| container_title | European journal of gynaecological oncology |
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| creator | Romanowicz-Makowska, H Smolarz, B Zadrozny, M Westfa, B Baszczyński, J Kokołaszwili, G Burzyfiski, M Połać, I Sporny, S |
| description | XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation.
In the present work the distribution of genotypes and frequency of alleles of the RAD51 G135C polymorphism, XRCC2 Arg 188His and XRCC3 Thr241Met polymorphism in 790 cases of breast cancer were investigated. The control group consisted of 798 cancer-free blood donors (age +/- 5 years) who were sex and ethnicity-matched. The polymorphisms were determined by PCR-RFLP methods. We also correlated genotypes with the clinical characteristics of breast cancer patients.
Our results obtained for the 135G>C polymorphism of the RAD51 gene indicated that both the C/C genotype and the C allele are strongly associated with breast cancer. The Arg/His genotype of XRCC2 (OR = 2.16, 95% CI = 1.48-3.16) and Thr/Met of XRCC3 increased the risk of type I breast cancer occurrence (OR = 2.33, 95% CI = 1.60-3.41). We did not find any association with the RAD51, XRCC2/3 gene polymorphism and estrogen and progesterone receptor status.
The results support the hypothesis that the polymorphism of RAD51 and XRCC2/3 gene may be associated with the incidence of sporadic breast cancer in Polish women. |
| format | Article |
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In the present work the distribution of genotypes and frequency of alleles of the RAD51 G135C polymorphism, XRCC2 Arg 188His and XRCC3 Thr241Met polymorphism in 790 cases of breast cancer were investigated. The control group consisted of 798 cancer-free blood donors (age +/- 5 years) who were sex and ethnicity-matched. The polymorphisms were determined by PCR-RFLP methods. We also correlated genotypes with the clinical characteristics of breast cancer patients.
Our results obtained for the 135G>C polymorphism of the RAD51 gene indicated that both the C/C genotype and the C allele are strongly associated with breast cancer. The Arg/His genotype of XRCC2 (OR = 2.16, 95% CI = 1.48-3.16) and Thr/Met of XRCC3 increased the risk of type I breast cancer occurrence (OR = 2.33, 95% CI = 1.60-3.41). We did not find any association with the RAD51, XRCC2/3 gene polymorphism and estrogen and progesterone receptor status.
The results support the hypothesis that the polymorphism of RAD51 and XRCC2/3 gene may be associated with the incidence of sporadic breast cancer in Polish women.</description><identifier>ISSN: 0392-2936</identifier><identifier>PMID: 22611952</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma - genetics ; Carcinoma - pathology ; Confidence Intervals ; DNA-Binding Proteins - genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Lymphatic Metastasis ; Middle Aged ; Odds Ratio ; Poland ; Polymorphism, Single Nucleotide ; Rad51 Recombinase - genetics ; Receptors, Estrogen - genetics ; Receptors, Progesterone - genetics</subject><ispartof>European journal of gynaecological oncology, 2012, Vol.33 (2), p.145-150</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22611952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romanowicz-Makowska, H</creatorcontrib><creatorcontrib>Smolarz, B</creatorcontrib><creatorcontrib>Zadrozny, M</creatorcontrib><creatorcontrib>Westfa, B</creatorcontrib><creatorcontrib>Baszczyński, J</creatorcontrib><creatorcontrib>Kokołaszwili, G</creatorcontrib><creatorcontrib>Burzyfiski, M</creatorcontrib><creatorcontrib>Połać, I</creatorcontrib><creatorcontrib>Sporny, S</creatorcontrib><title>The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland</title><title>European journal of gynaecological oncology</title><addtitle>Eur J Gynaecol Oncol</addtitle><description>XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation.
In the present work the distribution of genotypes and frequency of alleles of the RAD51 G135C polymorphism, XRCC2 Arg 188His and XRCC3 Thr241Met polymorphism in 790 cases of breast cancer were investigated. The control group consisted of 798 cancer-free blood donors (age +/- 5 years) who were sex and ethnicity-matched. The polymorphisms were determined by PCR-RFLP methods. We also correlated genotypes with the clinical characteristics of breast cancer patients.
Our results obtained for the 135G>C polymorphism of the RAD51 gene indicated that both the C/C genotype and the C allele are strongly associated with breast cancer. The Arg/His genotype of XRCC2 (OR = 2.16, 95% CI = 1.48-3.16) and Thr/Met of XRCC3 increased the risk of type I breast cancer occurrence (OR = 2.33, 95% CI = 1.60-3.41). We did not find any association with the RAD51, XRCC2/3 gene polymorphism and estrogen and progesterone receptor status.
The results support the hypothesis that the polymorphism of RAD51 and XRCC2/3 gene may be associated with the incidence of sporadic breast cancer in Polish women.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - pathology</subject><subject>Confidence Intervals</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Poland</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Rad51 Recombinase - genetics</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Progesterone - genetics</subject><issn>0392-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9Lw0AQxXNQbK1-BdmjBxf2X9LssURthYpSKngLk2TSriTZuLtB-mX8rEZbTwPv_ebNY86iKZNaUKFlMokuvf9gTKl5Ii6iiRAJ5zoW0-h7u0cC3tvSQDC2IwWGL8SO9LY5tNb1e-NbT2xNwghuFvcxp0su4-yOvG-yTNCF2_E0XRlPoKv-NEm3eycUf8ZAdtjh0Skb05nS0h7C3jZ2Z0pSI4TBjb4ZzzoEH0gJXYnuV3i1zbh2FZ3X0Hi8Ps1Z9Pb4sM1WdP2yfMoWa9oLzgOVGopKyQp4IQVq5CigqlPQc10xkJVSVZImmCapToUuseagAWqFNTI9V4mcRbfH3N7ZzwF9yFvjS2zGDmgHn3PGY5XETLIRvTmhQ9FilffOtOAO-f9P5Q9y43FQ</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Romanowicz-Makowska, H</creator><creator>Smolarz, B</creator><creator>Zadrozny, M</creator><creator>Westfa, B</creator><creator>Baszczyński, J</creator><creator>Kokołaszwili, G</creator><creator>Burzyfiski, M</creator><creator>Połać, I</creator><creator>Sporny, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland</title><author>Romanowicz-Makowska, H ; Smolarz, B ; Zadrozny, M ; Westfa, B ; Baszczyński, J ; Kokołaszwili, G ; Burzyfiski, M ; Połać, I ; Sporny, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-39abd43da1b32e9e1e2adf8a979d0a3d44d686e8689829cef1a9aaf4efe097463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - pathology</topic><topic>Confidence Intervals</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Poland</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Rad51 Recombinase - genetics</topic><topic>Receptors, Estrogen - genetics</topic><topic>Receptors, Progesterone - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romanowicz-Makowska, H</creatorcontrib><creatorcontrib>Smolarz, B</creatorcontrib><creatorcontrib>Zadrozny, M</creatorcontrib><creatorcontrib>Westfa, B</creatorcontrib><creatorcontrib>Baszczyński, J</creatorcontrib><creatorcontrib>Kokołaszwili, G</creatorcontrib><creatorcontrib>Burzyfiski, M</creatorcontrib><creatorcontrib>Połać, I</creatorcontrib><creatorcontrib>Sporny, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gynaecological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romanowicz-Makowska, H</au><au>Smolarz, B</au><au>Zadrozny, M</au><au>Westfa, B</au><au>Baszczyński, J</au><au>Kokołaszwili, G</au><au>Burzyfiski, M</au><au>Połać, I</au><au>Sporny, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland</atitle><jtitle>European journal of gynaecological oncology</jtitle><addtitle>Eur J Gynaecol Oncol</addtitle><date>2012</date><risdate>2012</risdate><volume>33</volume><issue>2</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0392-2936</issn><abstract>XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation.
In the present work the distribution of genotypes and frequency of alleles of the RAD51 G135C polymorphism, XRCC2 Arg 188His and XRCC3 Thr241Met polymorphism in 790 cases of breast cancer were investigated. The control group consisted of 798 cancer-free blood donors (age +/- 5 years) who were sex and ethnicity-matched. The polymorphisms were determined by PCR-RFLP methods. We also correlated genotypes with the clinical characteristics of breast cancer patients.
Our results obtained for the 135G>C polymorphism of the RAD51 gene indicated that both the C/C genotype and the C allele are strongly associated with breast cancer. The Arg/His genotype of XRCC2 (OR = 2.16, 95% CI = 1.48-3.16) and Thr/Met of XRCC3 increased the risk of type I breast cancer occurrence (OR = 2.33, 95% CI = 1.60-3.41). We did not find any association with the RAD51, XRCC2/3 gene polymorphism and estrogen and progesterone receptor status.
The results support the hypothesis that the polymorphism of RAD51 and XRCC2/3 gene may be associated with the incidence of sporadic breast cancer in Polish women.</abstract><cop>Italy</cop><pmid>22611952</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Alleles Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma - genetics Carcinoma - pathology Confidence Intervals DNA-Binding Proteins - genetics Female Gene Frequency Genotype Humans Lymphatic Metastasis Middle Aged Odds Ratio Poland Polymorphism, Single Nucleotide Rad51 Recombinase - genetics Receptors, Estrogen - genetics Receptors, Progesterone - genetics |
| title | The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland |
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