Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury

Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury

Abstract The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple...

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Veröffentlicht in:Journal of clinical anesthesia 2012-06, Vol.24 (4), p.318-323
Hauptverfasser: Nakagawa, Kazuma, MD, Chang, Cherylee W.J., MD, Koenig, Matthew A., MD, Yu, Mihae, MD, Tokumaru, Sheri, PharmD
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Anesthesia & Perioperative Care
Brain - diagnostic imaging
Brain damage
Brain Injuries - complications
Brain Injuries - diagnostic imaging
Brain Injuries - physiopathology
Child, Preschool
Children & youth
Female
Fluid Therapy - methods
Hemorrhage
Humans
Hypertension
Hypertonic saline
Infant
Intracranial hypertension
Intracranial Hypertension - diagnostic imaging
Intracranial Hypertension - etiology
Intracranial Hypertension - physiopathology
Intracranial Hypertension - therapy
Intracranial Pressure - physiology
Male
Mortality
Pain Medicine
Pediatric neurotrauma
Saline Solution, Hypertonic - therapeutic use
Tomography, X-Ray Computed
Traumatic brain injury
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Zusammenfassung:Abstract The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple 23.4% saline boluses in two children with severe traumatic brain injury (TBI) are presented. No complications were associated with the use of 23.4% saline in either patient.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2011.10.011