A Phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma

Despite the efficacy of gemcitabine-platinum regimen, the outcome of patients with recurrent and/or metastatic nasopharyngeal carcinoma (RM NPC) is poor. A phase II trial was conducted to determine the efficacy of erlotinib, given as maintenance therapy after gemcitabine-platinum chemotherapy in pat...

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Veröffentlicht in:	American journal of clinical oncology 2012-06, Vol.35 (3), p.255-260
Hauptverfasser:	You, Benoit, Le Tourneau, Christophe, Chen, Eric X, Wang, Lisa, Jarvi, Andrea, Bharadwaj, Rikki R, Kamel-Reid, Suzanne, Perez-Ordonez, Bayardo, Mann, Vijay, Siu, Lillian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carboplatin - administration & dosage Cisplatin - administration & dosage Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Disease Progression Erlotinib Hydrochloride Female Follow-Up Studies Humans Male Middle Aged Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - mortality Nasopharyngeal Neoplasms - pathology Neoplasm Metastasis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Staging Prognosis Quinazolines - administration & dosage Salvage Therapy Survival Rate
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