An improved methodology for data analysis in accelerated stability studies of peptide drugs: Practical considerations

► We evaluate various data analysis methods for assessing accelerated drugs stability. ► The shelf-life at 5°C varied from 2.2 to 4 years in function of used approach. ► The classic Arrhenius analysis showed the higher uncertainty. ► All these results were evaluated by the bootstrap approach. ► Data...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Talanta (Oxford) 2012-05, Vol.94, p.158-166
Hauptverfasser:	Oliva, Alexis, Fariña, José B., Llabrés, Matías
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Arrhenius Biological Products - analysis Bootstrap Chemistry Chromatography, Liquid Chromatography, Reverse-Phase Drug Stability Exact sciences and technology Humans Kinetics Mass Spectrometry Peptides Regression Analysis Regression method Research Design Stability Temperature Tetragastrin - analysis Thermodynamics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!