Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty
Abstract Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion (Al...
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| Veröffentlicht in: | The Journal of arthroplasty 2012-06, Vol.27 (6), p.961-967 |
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| container_title | The Journal of arthroplasty |
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| creator | Noticewala, Manish S., BA Nyce, Jonathan D., BS Wang, Wenbao, MD Geller, Jeffrey A., MD Macaulay, William, MD |
| description | Abstract Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion (AllTx) after primary TKA and, subsequently, develop a model to predict patients who will require AllTx. We analyzed 31 independent variables in 644 primary unilateral TKAs without autologous blood predonation for requirement of AllTx. Seventy-one procedures (11.0%) required AllTx. Age, comorbid anemia, preoperative hemoglobin concentration, and surgical time were significant predictors for requiring AllTx. When applied to an independent cohort, our model for predicting the need for AllTx after TKA was 90% sensitive and 52.5% specific. |
| doi_str_mv | 10.1016/j.arth.2011.10.008 |
| format | Article |
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To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion (AllTx) after primary TKA and, subsequently, develop a model to predict patients who will require AllTx. We analyzed 31 independent variables in 644 primary unilateral TKAs without autologous blood predonation for requirement of AllTx. Seventy-one procedures (11.0%) required AllTx. Age, comorbid anemia, preoperative hemoglobin concentration, and surgical time were significant predictors for requiring AllTx. When applied to an independent cohort, our model for predicting the need for AllTx after TKA was 90% sensitive and 52.5% specific.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2011.10.008</identifier><identifier>PMID: 22608172</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; allogeneic ; Anemia - epidemiology ; Arthroplasty, Replacement, Knee - statistics & numerical data ; autologous ; Blood Loss, Surgical - statistics & numerical data ; Blood Transfusion - statistics & numerical data ; Cohort Studies ; Comorbidity ; Female ; Hemoglobins - metabolism ; Humans ; Male ; Middle Aged ; Models, Statistical ; Orthopedics ; predonation ; Retrospective Studies ; Sensitivity and Specificity ; Time Factors ; total knee arthroplasty (TKA) ; transfusion ; Young Adult</subject><ispartof>The Journal of arthroplasty, 2012-06, Vol.27 (6), p.961-967</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-20f7f504c4642edfd4acf6557148aa00cd22630b34a62dd2d94a7bfb5eeed9fa3</citedby><cites>FETCH-LOGICAL-c411t-20f7f504c4642edfd4acf6557148aa00cd22630b34a62dd2d94a7bfb5eeed9fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0883540311005560$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22608172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noticewala, Manish S., BA</creatorcontrib><creatorcontrib>Nyce, Jonathan D., BS</creatorcontrib><creatorcontrib>Wang, Wenbao, MD</creatorcontrib><creatorcontrib>Geller, Jeffrey A., MD</creatorcontrib><creatorcontrib>Macaulay, William, MD</creatorcontrib><title>Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty</title><title>The Journal of arthroplasty</title><addtitle>J Arthroplasty</addtitle><description>Abstract Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion (AllTx) after primary TKA and, subsequently, develop a model to predict patients who will require AllTx. We analyzed 31 independent variables in 644 primary unilateral TKAs without autologous blood predonation for requirement of AllTx. Seventy-one procedures (11.0%) required AllTx. Age, comorbid anemia, preoperative hemoglobin concentration, and surgical time were significant predictors for requiring AllTx. When applied to an independent cohort, our model for predicting the need for AllTx after TKA was 90% sensitive and 52.5% specific.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>allogeneic</subject><subject>Anemia - epidemiology</subject><subject>Arthroplasty, Replacement, Knee - statistics & numerical data</subject><subject>autologous</subject><subject>Blood Loss, Surgical - statistics & numerical data</subject><subject>Blood Transfusion - statistics & numerical data</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Orthopedics</subject><subject>predonation</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Time Factors</subject><subject>total knee arthroplasty (TKA)</subject><subject>transfusion</subject><subject>Young Adult</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqGzEQhkVoady0L5BD2WMv6460kryBUDChbUpCEoh7FrI0SuXIkivtFvz21eIkhx5yEgzfP5r5hpBTCnMKVH7ZzHUefs8ZUFoLc4D-iMyo6Fjbc5BvyAz6vmsFh-6YvC9lAxUUgr8jx4xJ6OmCzcjlXUbrzeDjQ3ODaBuXcrMMIT1gRG-aVdaxuLH4FJulGzA3qzTo0FxFxGZZv89pF3QZ9h_IW6dDwY9P7wn59f3b6uKyvb798fNied0aTunQMnALJ4AbLjlD6yzXxkkhFpT3WgMYW2frYN1xLZm1zJ5xvVi7tcA63JnT3Qn5fOi7y-nPiGVQW18MhqAjprGoakYwzmXHKsoOqMmplIxO7bLf6ryv0MRJtVGTQTUZnGrVYA19euo_rrdoXyLPyipwfgCwbvnXY1bFeIymasxoBmWTf73_1__iJvjojQ6PuMeySWOO1Z-iqjAF6n664XRCSgGEkND9A-yCluU</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Noticewala, Manish S., BA</creator><creator>Nyce, Jonathan D., BS</creator><creator>Wang, Wenbao, MD</creator><creator>Geller, Jeffrey A., MD</creator><creator>Macaulay, William, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty</title><author>Noticewala, Manish S., BA ; Nyce, Jonathan D., BS ; Wang, Wenbao, MD ; Geller, Jeffrey A., MD ; Macaulay, William, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-20f7f504c4642edfd4acf6557148aa00cd22630b34a62dd2d94a7bfb5eeed9fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>allogeneic</topic><topic>Anemia - epidemiology</topic><topic>Arthroplasty, Replacement, Knee - statistics & numerical data</topic><topic>autologous</topic><topic>Blood Loss, Surgical - statistics & numerical data</topic><topic>Blood Transfusion - statistics & numerical data</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Orthopedics</topic><topic>predonation</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Time Factors</topic><topic>total knee arthroplasty (TKA)</topic><topic>transfusion</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noticewala, Manish S., BA</creatorcontrib><creatorcontrib>Nyce, Jonathan D., BS</creatorcontrib><creatorcontrib>Wang, Wenbao, MD</creatorcontrib><creatorcontrib>Geller, Jeffrey A., MD</creatorcontrib><creatorcontrib>Macaulay, William, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noticewala, Manish S., BA</au><au>Nyce, Jonathan D., BS</au><au>Wang, Wenbao, MD</au><au>Geller, Jeffrey A., MD</au><au>Macaulay, William, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>27</volume><issue>6</issue><spage>961</spage><epage>967</epage><pages>961-967</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>Abstract Total knee arthroplasty (TKA) can lead to substantial blood loss. To avoid the high costs of autologous blood predonation programs and efficiently allocate limited blood resources, we sought to identify preoperative and intraoperative factors associated with allogeneic blood transfusion (AllTx) after primary TKA and, subsequently, develop a model to predict patients who will require AllTx. We analyzed 31 independent variables in 644 primary unilateral TKAs without autologous blood predonation for requirement of AllTx. Seventy-one procedures (11.0%) required AllTx. Age, comorbid anemia, preoperative hemoglobin concentration, and surgical time were significant predictors for requiring AllTx. When applied to an independent cohort, our model for predicting the need for AllTx after TKA was 90% sensitive and 52.5% specific.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22608172</pmid><doi>10.1016/j.arth.2011.10.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over allogeneic Anemia - epidemiology Arthroplasty, Replacement, Knee - statistics & numerical data autologous Blood Loss, Surgical - statistics & numerical data Blood Transfusion - statistics & numerical data Cohort Studies Comorbidity Female Hemoglobins - metabolism Humans Male Middle Aged Models, Statistical Orthopedics predonation Retrospective Studies Sensitivity and Specificity Time Factors total knee arthroplasty (TKA) transfusion Young Adult |
| title | Predicting Need for Allogeneic Transfusion After Total Knee Arthroplasty |
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